Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$88K - $105K *

Analyze complex datasets to drive insights and enhance healthcare analytics. Collaborate with stakeholders to develop reporting solutions, ensuring data integrity and supporting strategic decision-mak...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Empower your career by leading IT security initiatives, assessing risks, and driving remediation efforts across the enterprise. Collaborate with cross-functional teams to enhance security posture and...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$121K - $182K *

Unlock potential by leading Oracle Cloud HCM integration efforts, ensuring technical soundness and alignment with transformation goals. Collaborate with cross-functional teams to drive innovative solu...

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$120K - $160K *

Champion the design and implementation of scalable data pipelines, ensuring data integrity and availability. Collaborate with cross-functional teams to optimize data workflows and enhance infrastructu...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$70K - $126K *

Join a dynamic team to enhance compliance initiatives, manage regulatory reporting, and lead projects. Play a key role in developing policies, conducting audits, and ensuring adherence to state and fe...

Missouri, USRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$140K - $175K *

Empower your career by driving impactful relationships in government sectors. Manage a dedicated account portfolio, enhance customer satisfaction, and lead strategic engagement initiatives to maximize...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Elevate data-driven decision-making by analyzing clinician networks to optimize patient care. Collaborate with cross-functional teams to enhance operational efficiency and improve healthcare outcomes...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$78K - $83K *

Shape the future of audit excellence by developing innovative concepts, mentoring teams, and ensuring quality control. Drive client satisfaction and enhance audit productivity through strategic oversi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$198K - $297K *

Champion utilization management by conducting patient reviews, collaborating with medical staff, and leading initiatives to enhance compliance and efficiency. Drive results through effective communica...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$94K - $293K *

Champion client success by optimizing membership administration operations, leveraging technology solutions, and leading project delivery. Build strong relationships while driving impactful results in...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Join a team that's leading Medicaid programs and initiatives, driving operational excellence and policy implementation while managing multidisciplinary teams and enhancing organizational performance a...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$85K - $95K *

Unlock potential by leading business analysis to transform processes into actionable requirements for a major financial management system. Collaborate with stakeholders to enhance workflows and ensure...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$68K - $103K *

Unlock potential by driving process improvements to reduce clinical and technical denials. Collaborate with teams to analyze trends, implement best practices, and enhance workflows, ensuring complianc...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Innovate data solutions by developing complex reports and analyses to support senior management and client needs. Collaborate with teams to enhance data literacy and provide technical guidance across...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$106K - $147K *

Champion the development of ML pipelines, ensuring scalable, reliable decision-making systems that optimize member outcomes while collaborating with cross-functional teams to enhance platform performa...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$73K - $98K *

Join a team that's dedicated to excellence in DRG auditing. Leverage your expertise in MS-DRG and APR-DRG coding to ensure accuracy and compliance while working remotely. Enjoy a collaborative environ...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Business Services

$70K - $110K *

Unlock your potential in healthcare with flexible telephonic disease management, where you'll conduct assessments, implement coaching plans, and coordinate care for chronic conditions, impacting membe...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Empower growth by developing strategic relationships with biotech and pharma clients. Drive market awareness and increase RFPs through collaboration with the business development team, leveraging your...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in optimizing clinical and operational excellence across multiple ambulatory clinics, ensuring effective provider management, financial oversight, and patient satisfaction while drivin...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $160K *

Analyze complex data and drive solutions as a Business Analyst in the public sector. Leverage your expertise in pension systems to identify issues and enhance processes, ensuring effective communicati...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$225K - $418K *

Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$111K - $149K *

Drive data-driven strategies by analyzing complex business data, collaborating with leaders, and developing actionable insights to enhance decision-making and optimize processes across various busines...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$68K - $105K *

Champion the implementation and support of Epic Beaker applications, ensuring effective system design, user experience, and problem resolution while managing projects and enhancing end-user engagement...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$113K - $188K *

Champion adolescent health initiatives by providing strategic guidance and support to federal agencies, enhancing youth engagement, and implementing evidence-based programs to improve outcomes for ado...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$134K - $209K *

Join a team that's redefining data architecture and analytics. Leverage your expertise to drive cloud adoption, modernize data platforms, and influence strategic initiatives that empower data-driven d...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.