Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$76K - $96K *

Drive the optimization of contract lifecycle management by supporting and enhancing the Conga CLM platform within Salesforce. Collaborate with cross-functional teams to streamline processes and improv...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Join a dynamic team to lead complex statistical analyses, drive innovative research projects, and collaborate with stakeholders to enhance business strategies through advanced statistical methodologie...

Reposted today

  •   Less than 5 years exp.  •   Finance & Insurance

$130K - $145K *

Elevate public health data interoperability by designing and implementing secure, scalable data pipelines. Collaborate with cross-functional teams to modernize legacy systems and ensure compliance, dr...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Transform healthcare data products by leading strategy, execution, and cross-functional collaboration. Drive product-market fit and commercialization for API-based solutions, ensuring alignment with c...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Join a dynamic team to enhance financial management practices and support critical operations. Collaborate across levels to drive process improvements and deliver impactful financial insights in a fas...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$142K - $177K *

Champion innovative risk adjustment solutions by leveraging deep expertise to enhance payer and provider strategies. Collaborate with cross-functional teams to deliver impactful presentations and driv...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Unlock potential by leading pre-sales technical strategies that align solutions with client needs, driving revenue growth and retention through collaboration with sales teams and delivering tailored p...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Analyze and deliver tailored technical solutions, collaborating with teams to implement AI-driven workflows and support complex data migrations, ensuring high-quality service outcomes and stakeholder...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$204K - $276K *

Empower healthcare innovation by leading strategic partnerships and account management to enhance access and drive growth for Alnylam products, ensuring mutual value creation for healthcare systems an...

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a team that's dedicated to transforming healthcare data into actionable insights. This role involves analyzing complex datasets, collaborating with stakeholders, and delivering data-driven recomm...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$274K - $356K *

Transform the actuarial function by leading AI-enabled workflows and modern analytics, improving decision-making and fostering collaboration across Finance, Clinical, and Growth teams while ensuring c...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$100K - $140K *

Transform data into actionable insights by collaborating with leadership to analyze, visualize, and communicate findings. Leverage expertise in business intelligence tools to enhance decision-making f...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$152K - $190K *

Drive the future of data analytics by leading a dynamic team to enhance enterprise data strategies, governance, and insights that align with business objectives and foster innovation across the organi...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$115K - $145K *

Drive AI transformation by managing strategic technology initiatives, ensuring clear communication and governance across teams. Your role is pivotal in navigating complexities and aligning priorities...

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$101K - $152K *

Champion innovative data solutions by designing and implementing Azure-based platforms. Engage in hands-on engineering to build reliable, scalable data pipelines and secure network architectures, ensu...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$90K - $120K *

Optimize operational excellence in healthcare IT by managing production support, driving issue resolution, and ensuring timely reporting for customer-facing technology delivery...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Analyze and optimize workforce management strategies across multiple business lines, translating complex forecasts into actionable capacity plans and financial models while collaborating with executiv...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $90K *

Drive your career with a Business Process Analyst role focused on enhancing wireless network operations through process analysis, mapping, and stakeholder collaboration to identify and implement impro...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's dedicated to enhancing client relationships and driving success. Oversee client performance, mentor staff, and ensure compliance while collaborating with various departments to deli...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Optimize patient care by managing oncology cases, performing assessments, and developing treatment plans. Collaborate with healthcare teams to ensure quality outcomes for patients undergoing chemother...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$92K - $167K *

Drive strategic initiatives in Medicare Advantage provider networks, analyzing data and collaborating with leadership to enhance performance and achieve goals. Lead complex projects from inception to...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$60K - $115K *

Transform your career by managing financial processes and compliance, analyzing project health, and training teams. Collaborate with stakeholders to ensure effective financial deliverables and reporti...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Real Estate & Construction

$94K - $151K *

Join a team that's shaping the future of insurance products by leading strategic initiatives, ensuring compliance, and driving market analysis. Collaborate with product managers to define vision and e...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$92K - $167K *

Drive compliance and contractor support in contracting standards, regulatory adherence, and policy execution. Work collaboratively across departments to provide strategic guidance, ensuring alignment...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$117K - $161K *

Drive impactful clinical intelligence initiatives by analyzing AI opportunities, conducting feasibility studies, and collaborating with cross-functional teams to enhance patient care and operational e...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.