Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Corporate Systems Application Analyst (Remote)
$76K - $96K *
Drive the optimization of contract lifecycle management by supporting and enhancing the Conga CLM platform within Salesforce. Collaborate with cross-functional teams to streamline processes and improv...
Reposted 4 days ago
$95K - $115K *
Join a dynamic team to lead complex statistical analyses, drive innovative research projects, and collaborate with stakeholders to enhance business strategies through advanced statistical methodologie...
Reposted today
$130K - $145K *
Elevate public health data interoperability by designing and implementing secure, scalable data pipelines. Collaborate with cross-functional teams to modernize legacy systems and ensure compliance, dr...
3 days ago
Senior Product Manager (Healthcare Data Products)
$120K - $145K *
Transform healthcare data products by leading strategy, execution, and cross-functional collaboration. Drive product-market fit and commercialization for API-based solutions, ensuring alignment with c...
5 days ago
$90K - $110K *
Join a dynamic team to enhance financial management practices and support critical operations. Collaborate across levels to drive process improvements and deliver impactful financial insights in a fas...
2 weeks ago
Senior Solutions Consultant - Risk Adjustment
$142K - $177K *
Champion innovative risk adjustment solutions by leveraging deep expertise to enhance payer and provider strategies. Collaborate with cross-functional teams to deliver impactful presentations and driv...
2 weeks ago
$120K - $145K *
Unlock potential by leading pre-sales technical strategies that align solutions with client needs, driving revenue growth and retention through collaboration with sales teams and delivering tailored p...
5 days ago
Technical Implementation Analyst
$80K - $95K *
Analyze and deliver tailored technical solutions, collaborating with teams to implement AI-driven workflows and support complex data migrations, ensuring high-quality service outcomes and stakeholder...
Today
$204K - $276K *
Empower healthcare innovation by leading strategic partnerships and account management to enhance access and drive growth for Alnylam products, ensuring mutual value creation for healthcare systems an...
6 days ago
Data Analyst (Databricks) REMOTE
$80K - $95K *
Join a team that's dedicated to transforming healthcare data into actionable insights. This role involves analyzing complex datasets, collaborating with stakeholders, and delivering data-driven recomm...
3 weeks ago
$274K - $356K *
Transform the actuarial function by leading AI-enabled workflows and modern analytics, improving decision-making and fostering collaboration across Finance, Clinical, and Growth teams while ensuring c...
Reposted today
Business Data Analyst (Remote)
$100K - $140K *
Transform data into actionable insights by collaborating with leadership to analyze, visualize, and communicate findings. Leverage expertise in business intelligence tools to enhance decision-making f...
1 week ago
$152K - $190K *
Drive the future of data analytics by leading a dynamic team to enhance enterprise data strategies, governance, and insights that align with business objectives and foster innovation across the organi...
5 days ago
$115K - $145K *
Drive AI transformation by managing strategic technology initiatives, ensuring clear communication and governance across teams. Your role is pivotal in navigating complexities and aligning priorities...
3 weeks ago
$101K - $152K *
Champion innovative data solutions by designing and implementing Azure-based platforms. Engage in hands-on engineering to build reliable, scalable data pipelines and secure network architectures, ensu...
Today
Healthcare IT Technical Operations Lead (Edifecs)
$90K - $120K *
Optimize operational excellence in healthcare IT by managing production support, driving issue resolution, and ensuring timely reporting for customer-facing technology delivery...
2 weeks ago
$90K - $110K *
Analyze and optimize workforce management strategies across multiple business lines, translating complex forecasts into actionable capacity plans and financial models while collaborating with executiv...
4 weeks ago
$75K - $90K *
Drive your career with a Business Process Analyst role focused on enhancing wireless network operations through process analysis, mapping, and stakeholder collaboration to identify and implement impro...
Yesterday
$110K - $130K *
Join a team that's dedicated to enhancing client relationships and driving success. Oversee client performance, mentor staff, and ensure compliance while collaborating with various departments to deli...
Reposted 6 days ago
Nurse Practitioner or Physician Assistant, Inpatient Oncology
$95K - $115K *
Optimize patient care by managing oncology cases, performing assessments, and developing treatment plans. Collaborate with healthcare teams to ensure quality outcomes for patients undergoing chemother...
5 days ago
Principle Div Consultant- Medicare Provider Network Strategy - Remote
$92K - $167K *
Drive strategic initiatives in Medicare Advantage provider networks, analyzing data and collaborating with leadership to enhance performance and achieve goals. Lead complex projects from inception to...
3 weeks ago
Analyst - Operations Financials I
$60K - $115K *
Transform your career by managing financial processes and compliance, analyzing project health, and training teams. Collaborate with stakeholders to ensure effective financial deliverables and reporti...
Today
Lead Product Analyst - Ancillary Products
$94K - $151K *
Join a team that's shaping the future of insurance products by leading strategic initiatives, ensuring compliance, and driving market analysis. Collaborate with product managers to define vision and e...
2 weeks ago
Prin Div Strategy Consultant - Governance (Remote)
$92K - $167K *
Drive compliance and contractor support in contracting standards, regulatory adherence, and policy execution. Work collaboratively across departments to provide strategic guidance, ensuring alignment...
Reposted 5 days ago
Informatics Lead, Clinical Intelligence
$117K - $161K *
Drive impactful clinical intelligence initiatives by analyzing AI opportunities, conducting feasibility studies, and collaborating with cross-functional teams to enhance patient care and operational e...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.