Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$90K - $110K *

Analyze healthcare data to enhance clinical insights and improve medication use. Collaborate with cross-functional teams to develop analytics tools and real-world evidence studies, driving better heal...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$102K - $138K *

Lead the charge in delivering actionable insights through advanced analytics, supporting employer group partners with healthcare claims and utilization data. Collaborate across teams to enhance report...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $115K *

Analyze and enhance client data reporting, driving insights and trends to support customer satisfaction and business growth. Collaborate with cross-functional teams to ensure data integrity and delive...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $105K *

Engage in strategic healthcare analytics to enhance operations, improve reimbursement processes, and drive data-driven insights. Collaborate cross-functionally to optimize quality and financial perfor...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$70K - $126K *

Analyze program outcomes and collaborate with stakeholders to enhance results. Manage complex projects, provide insights to leadership, and educate agencies on best practices to optimize performance a...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Analyze and optimize the clinical data lifecycle, ensuring data completeness and integrity. Collaborate cross-functionally to enhance clinical data flows and vendor strategies, driving quality improve...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Drive your career with a pivotal role in optimizing Epic Willow Ambulatory applications, enhancing pharmacy operations through strategic collaboration, innovative solutions, and robust system manageme...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Manage and optimize Epic Professional Billing workflows, focusing on Claims and Remittance. Serve as a key resource for end-users, troubleshooting issues and enhancing billing processes to ensure accu...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$66K - $114K *

Champion the analysis and development of actuarial data to support Medicaid pricing. Collaborate with teams to refine models and ensure data accuracy, while gaining valuable experience in a dynamic, h...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$94K - $164K *

Unlock potential by leading research and analysis to identify system impacts, dependencies, and business needs. Collaborate with stakeholders to enhance processes and deliver clear requirements in a d...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Transform patient access by optimizing Epic Cadence workflows. Collaborate with clinical teams to enhance scheduling efficiency and support system improvements, ensuring seamless operations and superi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Empower business success by collaborating with cross-functional teams to enhance operations, gather requirements, and implement IT solutions that align with strategic goals. Drive improvements in orde...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $110K *

Drive coding quality and compliance by analyzing data, supporting audits, and enhancing documentation practices. Collaborate with teams to ensure accurate coding and adherence to regulatory standards...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$92K - $126K *

Drive innovative solutions by blending product analytics and low-code development, collaborating cross-functionally to enhance AI Agent capabilities and optimize Revenue Cycle operations within the he...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$76K - $90K *

Join a team that's enhancing healthcare through expert support of EHR systems. Lead optimization initiatives, mentor junior analysts, and collaborate with diverse teams to improve clinical and operati...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$111K - $167K *

Join a dynamic team as a strategic analytics partner, driving insights and performance improvements across revenue cycle operations. Collaborate with leaders to define KPIs, analyze data, and create i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$81K - $142K *

Lead the design and development of enterprise data management solutions, collaborating with stakeholders to analyze requirements and enhance data processing capabilities using advanced technologies in...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$89K - $136K *

Innovate clinical application support to enhance patient care efficiency. Manage software upgrades, coordinate with IT teams, and lead projects while ensuring compliance and effective communication ac...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Join a team that's driving innovation in actuarial analysis. You'll tackle complex projects, conduct risk assessments, and mentor junior analysts, all while collaborating in a dynamic hybrid work envi...

Reposted 4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Engage in complex actuarial projects, analyzing risk contracts and training junior staff. Collaborate on pricing and management reports to support innovative capitation initiatives, fostering a dynami...

4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$85K - $110K *

Optimize clinical DRG audits by ensuring accuracy and consistency in coding. Mentor auditors, recommend process improvements, and conduct quality reviews to enhance performance and compliance in a rem...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$75K - $110K *

Join us to develop scalable analytics and reporting solutions that drive business decisions. Collaborate with teams to enhance data quality and automate processes, turning insights into impactful acti...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$85K - $100K *

Join our dynamic team to analyze and enhance ACO performance in Medicare VBC programs. Leverage your expertise in data analytics to drive insights, track KPIs, and support data-driven decision-making...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Join us to empower community coalitions in preventing youth substance use. As a Project Officer, you'll manage grants, provide technical assistance, and enhance local capacities, all while collaborati...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $110K *

Analyze and optimize public health programs by coordinating project activities, evaluating operational enhancements, and ensuring compliance with regulatory standards to improve health outcomes for af...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.