Explore $100K+ Jobs in Kentucky

Discover high-paying professional opportunities across Kentucky with Ladders. Browse vetted roles with salaries of $100,000 or more, from established employers and growing organizations. Whether you’re interested in positions in Louisville, Lexington, Bowling Green, or elsewhere in the state, find opportunities that fit your experience and career goals.

Professional Opportunities Across Kentucky

Kentucky’s economy spans healthcare, manufacturing, logistics, finance, technology, education, and other industries. Employers across the state seek experienced professionals for roles in leadership, operations, engineering, sales, healthcare administration, and more. The right opportunity may be available in a major metro area or in a smaller community.

Find a Role That Fits Your Experience

Use Ladders to explore opportunities suited to your skills, seniority, and compensation expectations. Review job descriptions, compare responsibilities, and identify roles where your professional background can make an impact. Listings on Ladders are vetted and pay at least $100,000.

Advance Your Career in Kentucky

Build your next career move by searching Kentucky jobs and narrowing results by location, industry, and role. Check listings regularly, tailor your resume to each opportunity, and highlight measurable accomplishments that demonstrate your value to prospective employers.

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$90K - $152K *

Unlock data-driven insights by analyzing complex datasets and developing AI-powered solutions. Collaborate with stakeholders to enhance reporting, automate workflows, and drive strategic business deci...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$158K - $197K *

Unlock potential by leading the automation of clinical data integration and dashboard development. Collaborate across teams to enhance data usability and implement AI solutions, ensuring compliance an...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$75K - $105K *

Optimize mainframe systems as a key analyst, ensuring stability and performance of IBM z/OS environments. Collaborate with teams to troubleshoot issues and maintain critical applications, while enhanc...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $112K *

Elevate your career by providing advanced governance, risk, and compliance support for federal information systems, ensuring compliance with federal laws and regulations while engaging with key stakeh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$212K - $409K *

Drive innovation as a key member of our engineering team, leveraging your expertise in software engineering and data platforms to shape solutions that enhance customer experiences and meet business go...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$132K - $165K *

Drive innovation in oncology diagnostics by leading statistical programming efforts, ensuring data integrity and compliance for clinical trials, while managing a team and collaborating cross-functiona...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Drive strategic oversight of enterprise-wide RAC audit activities, ensuring compliance and operational excellence. Collaborate with leadership to enhance audit processes, minimize financial risk, and...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$66K - $106K *

Optimize IT service delivery by managing configuration items, analyzing operational data, and ensuring effective incident resolution. Collaborate with cross-functional teams to enhance service perform...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$133K - $180K *

Help us transform healthcare solutions as you engage with clients, translate complex AI capabilities into actionable plans, and drive successful implementations within a collaborative environment focu...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$129K - $177K *

Shape the future of developer tooling by leading strategy and governance for an enterprise ecosystem. Collaborate with cross-functional teams to enhance developer experience, drive automation, and ens...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$210K - $225K *

Pioneer innovative research strategies to enhance clinical outcomes and drive impactful insights through collaboration across teams, while establishing a robust research infrastructure and publication...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$129K - $177K *

Develop and enhance reinforcement learning policies, ensuring optimal decisioning for healthcare outcomes. Manage the full RL lifecycle from data engineering to production deployment, elevating member...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$103K - $128K *

Shape the future of healthcare by driving risk adjustment solutions that enhance interoperability, improve documentation accuracy, and ensure compliance across Medicare, Medicaid, and ACA programs thr...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$103K - $128K *

Join us to lead product strategy and development, driving innovation and performance in healthcare solutions. Collaborate cross-functionally to align business needs with customer expectations and ensu...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Drive clinical quality improvements by translating needs into training and processes. Own record audits, partner with Product and Engineering for automation, and support clinical projects to enhance p...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $125K *

Drive the deployment of healthcare technology across multiple VA facilities, coordinating projects and ensuring readiness. Collaborate with diverse teams to manage timelines, resolve issues, and deliv...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $173K *

Join a team that's redefining AI-driven quality and performance operations. You'll build systems that enhance frontline team effectiveness and AI agent performance, ensuring impactful coaching and fee...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$89K - $113K *

Transform data integrity by assisting in the analysis and cleansing of Enterprise Business Systems. Collaborate with teams to resolve anomalies and ensure compliance with DoD standards while supportin...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $95K *

Drive patient safety initiatives by coordinating clinical support and managing risk assessment activities. Collaborate with leadership to enhance processes, reduce risks, and ensure a safer environmen...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $170K *

Elevate your career by managing a dynamic Palliative Care Program, providing clinical expertise, and leading a dedicated team. Drive process improvements and ensure high-quality patient care while fos...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Transform early phase clinical trials by leading design, execution, and oversight. Collaborate with cross-functional teams to ensure compliance and data integrity while managing project performance an...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$72K - $130K *

Engage in enhancing revenue integrity by ensuring accurate coding and charge capture for Cardiac Catheterization and Interventional Radiology services. Collaborate with clinical and operational teams...

Kentucky, USRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$68K - $143K *

Unlock innovative financial processes by driving transformation in logistics integration and optimizing resource allocation. Collaborate with diverse teams to enhance financial operations within the D...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Join our team to deliver expert emergency and primary care services, working closely with ED physicians while ensuring patient safety and performing essential clinical procedures and assessments...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Join a team that's dedicated to delivering high-quality emergency care, assessing and treating patients in a fast-paced environment while collaborating with physicians and maintaining essential skills...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Kentucky?question toggle

    Kentucky listings may include senior and experienced roles in areas such as healthcare, manufacturing, logistics, finance, technology, sales, engineering, and operations. Available positions vary by employer and location.

  • Which Kentucky cities have professional job opportunities?question toggle

    Opportunities may be found in Louisville, Lexington, Bowling Green, and communities throughout the state. Search by location to explore current openings near you.

  • Do jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with advertised salaries of $100,000 or more. Review each listing for its specific compensation details and requirements.

  • How can I find a high-paying job in Kentucky?question toggle

    Search Kentucky listings by city, role, or industry, then review the qualifications and compensation details. Tailor your resume to the position and emphasize relevant accomplishments and leadership experience.