Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$162K - $243K *
Lead a dynamic team in managing complex clinical research trials, ensuring strategic execution and client satisfaction. Drive project success through effective communication, budget oversight, and qua...
Yesterday
Project Manager, Industrial Controls Implementation
$116K - $170K *
Join a dynamic team to drive the planning and execution of PLC updates, ensuring seamless operations across automated warehouse sites while coordinating with cross-functional partners and enhancing de...
2 days ago
Director, Technology Project Management (Annuity Modernization Program)
$149K - $223K *
Drive the delivery of a strategic technology transformation initiative, overseeing complex modernization programs to enhance efficiency and customer experience. Collaborate with cross-functional teams...
Reposted 2 weeks ago
$125K - $172K *
Unlock potential by leading cross-functional teams to drive successful project outcomes, manage relationships within federal markets, and innovate solutions that enhance healthcare delivery and operat...
Reposted 1 week ago
$150K - $200K *
Lead the charge in delivering complex federal digital services programs, ensuring strategic direction, operational excellence, and strong customer relationships across multidisciplinary teams while ma...
Yesterday
Project Manager-Intralogistics
$80K - $95K *
Lead the charge in project management for innovative material handling automation, overseeing diverse technologies while managing budgets, resources, and client contracts for successful project execut...
1 month ago
$100K - $120K *
Elevate your career by leading technology-driven manufacturing projects. Drive complex initiatives from concept to delivery, ensuring quality and profitability while collaborating with cross-functiona...
4 days ago
Project Manager Data Center Rapid Deployment
$115K - $138K *
Manage complex data center deployment projects, ensuring timely delivery and alignment among stakeholders. Oversee planning, execution, and closeout while maintaining budget and risk controls in fast...
5 days ago
$180K - $220K *
Empower a dynamic team of software engineers to innovate and deliver impactful tech solutions, collaborating with cross-functional partners to enhance pediatric healthcare for children with special ne...
3 weeks ago
$126K - $162K *
Drive project success by leading design and construction phases, managing teams, and ensuring client satisfaction in commercial and mission-critical environments. Collaborate with stakeholders to deli...
1 week ago
$80K - $95K *
Help us manage diverse projects that drive strategic growth and collaboration across teams. As a key member of the EPMO, you'll ensure project success through effective stakeholder management and cont...
Yesterday
Project Manager, Business Improvement
$100K - $120K *
Empower your career by driving impactful business improvement initiatives. Collaborate with cross-functional teams to manage projects, analyze data, and enhance operational efficiency in a dynamic env...
1 week ago
$100K - $140K *
Empower global business practices by leading diverse project teams in innovative industries. Collaborate with stakeholders to ensure project success through effective management and integration of cut...
Reposted today
Director, Product Management (Value Added Solutions)
$160K - $210K *
Drive growth by leading the strategy and P&L for a high-impact product line. Collaborate cross-functionally, manage a talented team, and make strategic decisions to enhance partner offerings and reven...
2 days ago
Director of Program Management
$180K - $200K *
Drive cross-functional execution to align teams and deliver impactful systems. Lead complex initiatives, manage dependencies, and enhance operational practices as the organization scales. Foster colla...
3 weeks ago
Vice President, Project Management
$150K - $170K *
Lead the charge in transformative project management, driving cross-functional teams to execute multichannel initiatives successfully. Cultivate client relationships, ensure project delivery on-time...
4 weeks ago
Director of Engineering, Product
$250K - $290K *
Elevate your career by leading a high-performing engineering team, driving strategy and innovation in web3 technologies. Shape the future of decentralized systems while ensuring top-tier security and...
1 month ago
Director, People Business Partner - Product, Technology & AI
$150K - $180K *
Transform the future of talent management by partnering with Product and Technology leaders to design and implement a GM operating model, ensuring effective organizational strategies and people practi...
1 week ago
$150K - $210K *
Drive complex enterprise SaaS projects with a focus on alignment, execution, and risk management while engaging with stakeholders across all levels to ensure successful implementations and foster cont...
Reposted 2 weeks ago
Product Manager - Foundation Engineering
$158K - $248K *
Champion the development of the product roadmap for Observability and Compute/Network teams, ensuring alignment with reliability goals, system health monitoring, and infrastructure management strategi...
3 weeks ago
$125K - $135K *
Join a team that's dedicated to overseeing personnel and operational execution across critical Navy training programs. Lead multidisciplinary teams, manage contracts, and ensure successful program del...
4 days ago
$110K - $130K *
Drive impactful IT project delivery in a multi-site healthcare environment. Lead complex transformations, enhance governance, and foster stakeholder collaboration while ensuring tangible business outc...
1 month ago
Program Manager of Technical Development
$140K - $185K *
Drive technical excellence by developing standards and processes for commissioning, ensuring consistent execution across projects. Collaborate with cross-functional teams to enhance workforce capabili...
3 days ago
$140K - $150K *
Join a team that's driving strategic project execution and mentoring talent. Leverage advanced data analytics to build impactful dashboards and navigate stakeholder relationships, ensuring alignment w...
2 weeks ago
$90K - $110K *
Empower your career by driving project delivery and managing Agile teams. Utilize AI tools to enhance decision-making, anticipate risks, and ensure timely outcomes. Collaborate with stakeholders to ma...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.