Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Project Management Jobs in South Dakota

Sort By: Relevance

$110K - $130K *

Drive product strategy and execution in a dynamic B2B software environment. Collaborate with engineers and designers to simplify complex workflows, ensuring timely delivery and high-quality outcomes w...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $122K *

Unlock potential by leading a dynamic accounting team, managing full-cycle accounting processes, ensuring compliance, and driving process improvements in a fast-paced environment. Collaborate with fin...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$139K - $235K *

Transform customer infrastructure management by owning the product vision and roadmap for a key control plane. Collaborate with engineering to enhance user experience and operational efficiency, drivi...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Elevate your career by leading the product-led growth strategy for an AI-native platform. Own the customer journey from discovery to expansion, driving user adoption and monetization through innovativ...

United StatesRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Media

$160K - $297K *

Empower your career by leading innovative marketing strategies that drive growth and enhance brand visibility. Collaborate with cross-functional teams to optimize campaigns and achieve revenue goals i...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$172K - $210K *

Transform regulatory operations by leading submission strategies, managing systems, and ensuring compliance across portfolios while collaborating with cross-functional teams for successful outcomes...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $220K *

Shape the future of customer solutions by leading implementations and driving adoption of innovative technologies. Collaborate with teams to deliver tailored architectural designs that meet strategic...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $206K *

Advance lifecycle marketing strategies to engage millions of renters, driving revenue and enhancing user experience. Lead a small team while building innovative programs from the ground up, integratin...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$240K - $330K *

Transform the GTM Systems landscape by leading strategy, architecture, and operations. Drive efficiency across Sales, Marketing, and Customer Success through innovative solutions and data governance...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$262K - $394K *

Accelerate progress at Clio Phones by leading the growth of a cloud-native VoIP platform for law firms. Own P&L, build operational plans, and drive market strategy while managing cross-functional team...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$150K - $180K *

Drive strategic initiatives and operational excellence across a global portfolio, partnering with leadership to enhance business performance and deliver measurable outcomes in oncology and rare diseas...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$108K - $122K *

Champion exceptional corporate events by leading strategy, design, and execution of high-impact experiences for clients and executives, ensuring alignment with business goals and delivering premium se...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$84K - $103K *

Join a team that shapes the future of partner integrations by defining strategies and driving execution across platforms to enhance operational efficiency and client value while collaborating with sta...

United StatesRemote

Reposted 1 month ago

  •   Less than 5 years exp.  •   Enterprise Technology

$180K - $220K *

Join a team that's driving innovative oncology solutions while overseeing clinical trials, ensuring patient safety, and collaborating with cross-functional teams to contribute to impactful drug develo...

United StatesRemote

Reposted 1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Execute accurate coding practices to ensure compliance and optimal reimbursement in a dynamic healthcare environment. Collaborate with clinical teams to maintain integrity and efficiency in revenue cy...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $150K *

Drive the marketing strategy and execution from the ground up. Collaborate with cross-functional teams to build scalable demand-generation programs to boost qualified pipeline and revenue for innovati...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$122K - $203K *

Empower teams by leading data governance initiatives, enhancing data quality, and fostering collaboration across business domains. Drive operational excellence and ensure compliance while developing a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Build and lead a scalable U.S. service organization for battery energy storage systems, ensuring customer satisfaction and operational excellence throughout the post-sale lifecycle, from commissioning...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$190K - $270K *

Shape the future of restaurant technology by leading end-to-end design, collaborating with engineers and product leaders, and creating intuitive experiences that empower local businesses to thrive in...

RemoteRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Consumer Technology

$120K - $135K *

Support the growth of health plan accounts by fostering client relationships, analyzing data, and driving retention in a fast-paced, independent role. Leverage strong communication and analytical skil...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$120K - $145K *

Transform legal operations by leading technology assessments and implementations. Collaborate with clients to enhance contracting processes, leveraging expertise in CLM and AI solutions while mentorin...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$101K - $170K *

Manage and enhance systems-focused projects by coordinating cross-functional teams to improve performance, stability, and user experience. Drive data-driven decisions while balancing competing priorit...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$122K - $204K *

Optimize global trade compliance by leading initiatives that ensure adherence to import, export, and customs regulations while balancing operational efficiency and commercial objectives across diverse...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$166K - $216K *

Drive the development of innovative cardiac monitoring firmware by leading a dynamic team, enhancing engineering practices, and collaborating cross-functionally in a fast-paced, regulated environment...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$120K - $150K *

Lead the charge in developing strategic frameworks that translate business objectives into actionable insights. Collaborate cross-functionally to identify growth opportunities and influence decision-m...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.