Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$110K - $130K *
Transform enterprise IT projects by leading cloud migration and infrastructure modernization initiatives. Drive cross-functional collaboration, manage project lifecycles, and ensure alignment with str...
3 weeks ago
$110K - $140K *
Pioneer GxP compliance in digital quality management, ensuring software and AI products meet regulatory standards. Collaborate with stakeholders to enhance quality processes and support audits, drivin...
1 week ago
$120K - $150K *
Join our team to lead innovative process improvement initiatives that enhance operational efficiency and deliver measurable results. Drive cross-functional collaboration and cultivate a culture of con...
Reposted 3 weeks ago
Senior Director Software Engineering
$286K - $326K *
Champion engineering excellence by leading high-performing teams to innovate scalable, customer-centric solutions. Drive technical strategy and architecture while fostering a culture of continuous lea...
1 week ago
Salesforce Engineering Manager (US)
$135K - $160K *
Lead our Salesforce engineering team to enhance architecture, scalability, and performance. Collaborate with Product and Engineering leaders to mentor developers and deliver high-quality enterprise so...
4 weeks ago
$80K - $95K *
Advance your career with a remote role leading a claims team. Oversee investigations, manage workloads, and drive success while ensuring compliance with company standards and fostering team developmen...
Reposted 4 weeks ago
$80K - $95K *
Transform customer experiences by designing, integrating, and optimizing innovative automation solutions. Collaborate with diverse clients to deliver technical excellence and enhance service delivery...
Reposted 3 weeks ago
Service Project Manager - Mining and Materials
$79K - $127K *
Shape excellence by leading service project delivery and fostering customer satisfaction. This dynamic role demands robust management skills in the North American mining and material market, ensuring...
Reposted 2 weeks ago
Product Commercialization Manager
$91K - $121K *
Optimize the commercialization process by owning end-to-end management, collaborating across functions, and leveraging AI tools to enhance efficiency and scalability, ultimately driving data integrity...
Reposted 2 weeks ago
Director of Tier 3 and Support Engineering
$125K - $150K *
Lead the charge in enhancing customer support by managing Tier 3 Support and Support Engineering teams. Drive technical resolutions, streamline escalations, and foster team development within a dynami...
1 week ago
$215K - $235K *
Advance drug substance development and drive clinical readiness projects by leading process chemistry initiatives, collaborating with cross-functional teams, and ensuring regulatory compliance for suc...
Reposted 2 weeks ago
$120K - $150K *
Join a dynamic team to shape corporate strategy by translating insights into actionable recommendations that drive growth. Collaborate cross-functionally to identify opportunities and influence decisi...
6 days ago
$120K - $135K *
Elevate our proposal management efforts by leading strategic submissions, fostering collaboration among teams, and enhancing our pursuit capabilities to secure high-value projects that improve infrast...
2 days ago
Senior Product Manager (Intuitial)
$158K *
Lead the charge in delivering impactful solutions for Veterans by managing a cross-functional agile team, driving product direction, and fostering collaboration across multiple stakeholders to enhance...
2 days ago
$110K - $125K *
Lead and develop a high-performing Solution Consulting team, driving strategic engagements and delivering impactful product demonstrations to agency and brokerage clients. Collaborate cross-functional...
1 week ago
$170K - $200K *
Champion the evolution of exposure management by leading the design and implementation of a robust operating model, ensuring effective risk reduction and accountability across security operations and...
Reposted yesterday
Associate Director, Clinical Operations (Clinical Trial Management)
$120K - $145K *
Champion operational excellence in clinical trials by leading a team of Clinical Trial Managers. Drive strategic initiatives, ensure compliance, and enhance sponsor relationships while delivering stud...
2 weeks ago
Senior Manager, Internal Communications
$110K - $130K *
Lead the charge in enhancing internal communications to connect a growing, remote workforce. Collaborate with leadership to create clear, engaging messages that align employees with company priorities...
1 week ago
Manager, Home Center Analytics Enablement
$100K - $120K *
Transform data into actionable insights by leading analytics solutions that drive decision-making and improve performance. Collaborate across functions to establish trusted metrics and promote self-se...
2 weeks ago
$126K - $168K *
Transform the Connected Aircraft portfolio by leading product strategy and execution for Flight Management Systems. Collaborate cross-functionally to drive business growth, align customer needs, and d...
2 days ago
GTM Strategy & Operations Manager- Special Projects
$147K - $211K *
Empower business leaders by driving strategic initiatives that enhance performance across Sales and Account Management. Utilize data-driven insights to translate complex challenges into actionable pla...
1 week ago
$200K - $232K *
Unlock potential by leading legal reviews for promotional and medical materials. Collaborate across teams to ensure compliance and provide practical guidance in a fast-paced environment, supporting pr...
1 week ago
Construction Project Manager - Full Time
$80K - $95K *
Execute comprehensive project management for hospital and clinic construction, overseeing all phases from design to occupancy. Collaborate with stakeholders to ensure compliance, budget adherence, and...
2 weeks ago
$100K - $120K *
Lead the charge in ensuring technical excellence and quality across all P&C project deliverables. Provide mentorship, establish engineering standards, and drive continuous improvement initiatives to e...
2 days ago
Senior Principal Portfolio and Offer Management
$170K - $200K *
Drive portfolio strategy and execution by transforming market needs into profitable offers. Collaborate across teams to ensure alignment and operational readiness, enhancing sales confidence and optim...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.