Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Project Management Jobs in South Dakota

Sort By: Relevance

$180K - $230K *

Join a dynamic team as you lead engineering efforts to develop an AI Patient Engagement Agent, transforming clinical trials by automating patient interactions and enhancing operational efficiency for...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $230K *

Lead the charge in optimizing manufacturing processes through effective management of the Automation and Controls team, ensuring strategic alignment with innovation initiatives while fostering a cultu...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$150K - $190K *

Drive member activation by leading a cross-functional team to optimize outreach, incentives, and messaging strategies. Own the activation roadmap and funnel metrics to enhance engagement and ensure sc...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Shape the future of client engagement and service delivery, driving Professional Services success in the U.S. Public Sector. Collaborate with teams to boost revenue generation, enhance client relation...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$67K - $199K *

Elevate our healthcare solutions by spearheading product management for critical document services, collaborating across teams to ensure seamless integration and user experience, ultimately enhancing...

RemoteRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead transformative facilities initiatives by analyzing data, optimizing performance, and managing capital projects. Collaborate across teams to drive efficiency, reduce costs, and enhance restaurant...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Food & Beverages

$160K - $200K *

Shape the future of our web strategy by leading a cross-functional team to optimize user experience, drive demand generation, and enhance web performance. Your expertise will transform our website int...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $160K *

Elevate digital experiences by guiding site operations and enhancing user engagement. Collaborate with cross-functional teams to implement innovative features and optimize performance metrics, driving...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Empower a team by leading GIS and Real Property projects, enhancing data quality and usability for Army installations. Collaborate with stakeholders to deliver innovative geospatial solutions and ensu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Optimize quality operations for large-scale data pipelines, ensuring high standards and consistency across diverse datasets. Lead a team to enhance efficiency and reliability in audio data processing...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Drive software engineering initiatives by leading teams to deliver innovative digital solutions. Define technology strategy, oversee development processes, and foster a culture of excellence and colla...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$80K - $90K *

Join a team that's transforming customer onboarding by leading complex implementations, aligning stakeholders, and delivering scalable solutions that drive success and revenue. Your expertise will bri...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$236K - $296K *

Lead innovative product initiatives by owning vision, strategy, and execution. Collaborate with cross-functional teams to transform ideas into scalable solutions, driving impactful outcomes for the co...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$115K - $202K *

Transform the enterprise landscape by guiding technology strategies that align business goals with IT capabilities, ensuring efficient operational performance and supporting growth through best practi...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $180K *

Join a team that's redefining data products on a modern platform. As a Senior Technical Product Manager, you'll drive the strategy for our data platform and API, ensuring quality, governance, and a se...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$125K - $150K *

Drive the evolution of a next-gen Privileged Access Management platform, collaborating across teams to create user-centric and secure solutions while ensuring technical excellence and scalability in a...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$139K - $202K *

Pioneer a transformative approach in customer onboarding and implementations by leading high-impact teams. Drive technical excellence, enhance customer journey, and cultivate trusted partnerships acro...

RemoteRemote

Reposted 1 month ago

  •   8 - 10 years exp.  •   Information Technology

$201K - $251K *

Shape the future of revenue accounting by leading critical processes and driving scalable methodologies to support commercial growth. Collaborate with cross-functional teams to deliver actionable fina...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $155K *

Unlock potential by leading strategic partnerships in Creative Software Licensing. Drive growth through innovative deals, build relationships with developers, and shape the future of digital tools for...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Media

$95K - $115K *

Lead and enhance day-to-day accounting operations, focusing on accounts payable, receivable, and cash management. Collaborate with cross-functional teams to ensure accurate, timely transactions while...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $165K *

Elevate your career as a Scientific Product Owner, driving innovation in clinical genomics software. Collaborate with cross-functional teams to translate scientific needs into actionable requirements...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$300K - $500K *

Join a team that's driving the clean energy transition by leading complex debt transactions. As a senior deal leader, you'll manage a diverse portfolio, mentor junior members, and collaborate across t...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$275K - $300K *

Join a dynamic team as you lead quality and technical governance for mission-critical facilities, ensuring operational readiness and continuous improvement across the facility lifecycle from design to...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $220K *

Lead the charge in defining product strategy and delivery for major client engagements. Collaborate with cross-functional teams, mentor PMs, and navigate complex challenges to ensure successful outcom...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $220K *

Shape the future of product strategy by leading complex client engagements, managing the full product lifecycle, driving cross-functional alignment, and mentoring teams to deliver impactful solutions...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.