Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Director, Engineering (AI Patient Engagement Platform)
$180K - $230K *
Join a dynamic team as you lead engineering efforts to develop an AI Patient Engagement Agent, transforming clinical trials by automating patient interactions and enhancing operational efficiency for...
2 weeks ago
Director, Automation & Controls
$180K - $230K *
Lead the charge in optimizing manufacturing processes through effective management of the Automation and Controls team, ensuring strategic alignment with innovation initiatives while fostering a cultu...
Reposted 1 week ago
$150K - $190K *
Drive member activation by leading a cross-functional team to optimize outreach, incentives, and messaging strategies. Own the activation roadmap and funnel metrics to enhance engagement and ensure sc...
2 weeks ago
Client Director- Professional Services Sales Public Sector
$125K - $150K *
Shape the future of client engagement and service delivery, driving Professional Services success in the U.S. Public Sector. Collaborate with teams to boost revenue generation, enhance client relation...
3 weeks ago
Senior Technical Product Manager-Documents Domain-Epic
$67K - $199K *
Elevate our healthcare solutions by spearheading product management for critical document services, collaborating across teams to ensure seamless integration and user experience, ultimately enhancing...
Reposted 1 month ago
Manager, Facilities Transformation & Capital Programs
$110K - $130K *
Lead transformative facilities initiatives by analyzing data, optimizing performance, and managing capital projects. Collaborate across teams to drive efficiency, reduce costs, and enhance restaurant...
3 weeks ago
Senior Director, Web Strategy and Operations
$160K - $200K *
Shape the future of our web strategy by leading a cross-functional team to optimize user experience, drive demand generation, and enhance web performance. Your expertise will transform our website int...
2 days ago
Director of E-Commerce & Digital Product
$130K - $160K *
Elevate digital experiences by guiding site operations and enhancing user engagement. Collaborate with cross-functional teams to implement innovative features and optimize performance metrics, driving...
Reposted 1 week ago
GIS / Real Property Project Manager
$100K - $120K *
Empower a team by leading GIS and Real Property projects, enhancing data quality and usability for Army installations. Collaborate with stakeholders to deliver innovative geospatial solutions and ensu...
1 week ago
$150K - $180K *
Optimize quality operations for large-scale data pipelines, ensuring high standards and consistency across diverse datasets. Lead a team to enhance efficiency and reliability in audio data processing...
2 weeks ago
Digital Solutions Development Manager
$125K - $150K *
Drive software engineering initiatives by leading teams to deliver innovative digital solutions. Define technology strategy, oversee development processes, and foster a culture of excellence and colla...
2 days ago
Professional Services Manager (Implementation Manager)
$80K - $90K *
Join a team that's transforming customer onboarding by leading complex implementations, aligning stakeholders, and delivering scalable solutions that drive success and revenue. Your expertise will bri...
Reposted 4 days ago
Group Product Management Manager
$236K - $296K *
Lead innovative product initiatives by owning vision, strategy, and execution. Collaborate with cross-functional teams to transform ideas into scalable solutions, driving impactful outcomes for the co...
Yesterday
$115K - $202K *
Transform the enterprise landscape by guiding technology strategies that align business goals with IT capabilities, ensuring efficient operational performance and supporting growth through best practi...
Reposted 2 weeks ago
Senior Technical Product Manager
$130K - $180K *
Join a team that's redefining data products on a modern platform. As a Senior Technical Product Manager, you'll drive the strategy for our data platform and API, ensuring quality, governance, and a se...
1 week ago
Senior Technical Product Manager, Privileged Access Management (PAM)
$125K - $150K *
Drive the evolution of a next-gen Privileged Access Management platform, collaborating across teams to create user-centric and secure solutions while ensuring technical excellence and scalability in a...
Reposted 3 weeks ago
Senior Manager Implementation and Onboarding
$139K - $202K *
Pioneer a transformative approach in customer onboarding and implementations by leading high-impact teams. Drive technical excellence, enhance customer journey, and cultivate trusted partnerships acro...
Reposted 1 month ago
Director, Revenue Accounting and Finance
$201K - $251K *
Shape the future of revenue accounting by leading critical processes and driving scalable methodologies to support commercial growth. Collaborate with cross-functional teams to deliver actionable fina...
1 week ago
Associate Director, Business Development (Creative Tools, Game Development, and Learning)
$110K - $155K *
Unlock potential by leading strategic partnerships in Creative Software Licensing. Drive growth through innovative deals, build relationships with developers, and shape the future of digital tools for...
6 days ago
$95K - $115K *
Lead and enhance day-to-day accounting operations, focusing on accounts payable, receivable, and cash management. Collaborate with cross-functional teams to ensure accurate, timely transactions while...
2 days ago
$120K - $165K *
Elevate your career as a Scientific Product Owner, driving innovation in clinical genomics software. Collaborate with cross-functional teams to translate scientific needs into actionable requirements...
5 days ago
Principal, Business Management - Debt
$300K - $500K *
Join a team that's driving the clean energy transition by leading complex debt transactions. As a senior deal leader, you'll manage a diverse portfolio, mentor junior members, and collaborate across t...
3 weeks ago
VP, Data Center Facilities Engineering
$275K - $300K *
Join a dynamic team as you lead quality and technical governance for mission-critical facilities, ensuring operational readiness and continuous improvement across the facility lifecycle from design to...
3 weeks ago
Staff Product Manager, Technical
$160K - $220K *
Lead the charge in defining product strategy and delivery for major client engagements. Collaborate with cross-functional teams, mentor PMs, and navigate complex challenges to ensure successful outcom...
4 days ago
Staff Product Manager, Technical
$160K - $220K *
Shape the future of product strategy by leading complex client engagements, managing the full product lifecycle, driving cross-functional alignment, and mentoring teams to deliver impactful solutions...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.