Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$100K - $120K *
Elevate your career by driving product delivery excellence across teams. You'll ensure timely resolution of client requests and bugs, coordinating efforts between Product, Engineering, and Customer Ex...
3 weeks ago
$105K - $135K *
Transform product vision into reality by driving execution and collaboration across teams. Leverage data and AI to enhance risk data accessibility, ensuring customers can act swiftly and confidently o...
2 weeks ago
$120K - $145K *
Lead the charge in driving strategic sales initiatives, managing key accounts, and fostering long-term partnerships. Collaborate with cross-functional teams to identify growth opportunities and delive...
1 week ago
$160K - $200K *
Shape the future of product strategy by leading a high-performing team, driving innovation, and ensuring alignment across operations and technology to deliver exceptional customer value and measurable...
1 week ago
Sr. Program Manager - Implementation
$115K - $140K *
Engage as an experienced implementation leader managing complex client onboarding and execution of digital banking solutions. Collaborate across teams to drive project success, enhance operational eff...
3 weeks ago
Steel Fabrication Project Manager
$90K - $110K *
Join a team that's dedicated to delivering exceptional customer service while managing multiple projects efficiently. You'll ensure satisfaction and profitability, collaborating across departments to...
5 days ago
Technical Program Manager, Network
$180K - $230K *
Lead complex, multi-workstream technology programs, ensuring alignment across teams and delivering customer outcomes through strategic planning, execution, and governance. Drive program success by man...
5 days ago
Senior Manager, Lifecycle Marketing
$181K - $245K *
Elevate your career by leading lifecycle marketing strategies that enhance customer engagement, retention, and monetization. Drive impactful programs while managing a high-performing team and collabor...
3 days ago
$149K - $198K *
Lead the charge in transforming legal operations by designing scalable support models, managing a dedicated team, and leveraging technology to enhance service delivery across Legal & Public Policy fun...
Reposted 5 days ago
Director, Events & Experiences
$110K - $130K *
Launch impactful B2B events by developing strategies, managing budgets, and executing flawless experiences. Collaborate with marketing leaders to enhance brand presence and foster relationships throug...
Reposted 2 days ago
$145K - $175K *
Unlock potential by serving as a strategic advisor to enterprise clients, guiding them through complex stakeholder environments with predictive intelligence and data-driven insights to drive impactful...
1 week ago
$110K - $130K *
Lead the charge in transforming complex genomic data into compelling narratives that resonate with audiences, driving engagement across diverse channels while collaborating with cross-functional teams...
3 days ago
Senior Product Manager, Monetization Platform
$130K - $219K *
Transform the monetization landscape by leading product strategies that drive market success. Collaborate across diverse product lines to enhance pricing models and optimize profitability, ensuring im...
2 weeks ago
Associate Director, CMC Regulatory
$177K - $221K *
Lead the development and execution of global CMC regulatory strategies to support clinical trials and market applications, ensuring compliance with regulatory requirements throughout the product lifec...
3 days ago
$105K - $145K *
Collaborate with cross-functional teams to design integrated solutions that enhance user experience, leveraging AI tools and a design system to create cohesive workflows and drive product value in a B...
2 weeks ago
Director, Sourcing & Procurement
$190K - $237K *
Optimize sourcing strategies and procurement processes for clinical operations, ensuring effective vendor management and governance across global clinical trials. Collaborate with cross-functional tea...
1 week ago
AVP, Strategy and Executive Operations (Chief of Staff
$135K - $160K *
Lead the charge in enhancing executive effectiveness and strategic planning. Serve as a trusted advisor to senior leadership, coordinating cross-functional priorities and driving organizational alignm...
5 days ago
$150K - $180K *
Innovate product management across a diverse SaaS portfolio, leading teams to enhance strategy and execution. Collaborate with executives to drive growth and operational excellence in global markets...
2 weeks ago
Director of Construction Delivery
$220K - $340K *
Champion construction delivery excellence across global data center sites, managing GC performance and budgets of $25M+. Lead strategy, negotiate contracts, and represent construction risks to executi...
2 weeks ago
$168K - $285K *
Shape the future of financial strategy by leading R&D finance, partnering with executives to drive investment decisions, optimize spending, and enhance forecasting accuracy in a dynamic, AI-driven env...
1 week ago
Process Improvement Manager - Operations Excellence
$100K - $120K *
Transform your career by leading process improvement initiatives across a global operations team, focused on automation and project management to enhance overall efficiency and impact...
3 weeks ago
$120K - $150K *
Lead the charge in product innovation by managing the full lifecycle from ideation to launch. Collaborate with cross-functional teams to align technical and business goals, ensuring successful product...
1 week ago
Localization Technical Program Manager
$115K - $149K *
Join a team that's at the forefront of localization innovation, driving global product readiness by connecting engineering with scalable localization systems and technical programs. Lead efforts in in...
4 weeks ago
Program Manager, AI Enablement
$190K - $210K *
Lead the charge in strategic AI initiatives, coordinating cross-functional teams to drive program success. Utilize your program management expertise to align priorities, manage risks, and enhance AI c...
1 week ago
Appian Forward Deployed Product Owner
$148K - $247K *
Join a team that's driving digital transformation in financial services. Leverage your expertise in Appian to design and optimize workflows, collaborate with stakeholders, and enhance client-centric s...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.