Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Project Management Jobs in South Dakota

Sort By: Relevance

$168K - $231K *

Drive transformation by partnering with cross-functional teams to design and implement effective product operations, ensuring alignment with strategic goals and enhancing organizational effectiveness...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Join our dynamic Account Management Team to drive growth in the corporate occupier software market. Leverage your sales expertise to build lasting client relationships and uncover new opportunities wh...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Business Services

$120K - $145K *

Lead strategic product initiatives in advanced surgical technologies, driving development and commercialization efforts. Collaborate with cross-functional teams to enhance orthopedic outcomes and proc...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$401K - $500K+*

Join a team that's shaping the future of infrastructure engineering by leading efforts for cloud platforms, scaling developer experiences, and unlocking transformative AI solutions to enhance producti...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$200K - $245K *

Pioneer data-driven engineering for our Autonomy Data Flywheel initiative, overseeing the entire lifecycle to enhance AI-driven operations. Collaborate with cross-functional teams to achieve quality a...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Transportation

$140K - $170K *

Lead product outcomes by deeply understanding customer needs and driving value through collaboration with design and engineering teams. Own the entire problem-solving arc from conception to delivery...

Rapid City, SDRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $170K *

Champion customer value by owning product outcomes and driving meaningful solutions. Collaborate closely with design and engineering to ensure alignment from problem discovery to delivery, while influ...

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $155K *

Deliver impactful educational experiences by building strategic partnerships and developing innovative medical education programs to enhance clinical outcomes and drive growth in healthcare training...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$114K - $151K *

Unlock potential by leading the HV overhead switchgear portfolio, driving product strategy, market development, and cross-functional collaboration to achieve profitable growth and enhance utility solu...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$181K - $200K *

Champion transformative call center operations by leading strategic outreach, workforce management, and capacity planning. Drive efficiency and quality through innovative automation and AI solutions w...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Champion the vision and strategy for AI-powered products, driving their roadmap and delivery while mentoring peers. Leverage AI tools to enhance decision-making and product lifecycle management, ensur...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Champion the optimization of business systems for Legal, Safety, and Environmental teams. Drive continuous improvement and support for Icertis and related applications, enhancing user experience and o...

RemoteRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$170K - $190K *

Oversee the technical planning and implementation of control systems, ensuring effective deployment and support for FRCS Petaluma. Lead project management efforts, maintain documentation, and provide...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$80K - $125K *

Join a team that's dedicated to enhancing the customer experience through strategic vendor management and operational excellence. Lead initiatives that drive performance, compliance, and continuous im...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Partner with us to transform customer experience operations into a seamless, data-driven journey. Your leadership will unify departments for consistency, enabling effective strategies that enhance cus...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$115K - $140K *

Join a team that's dedicated to transforming patient engagement through innovative marketing strategies. You'll develop and execute multichannel campaigns, crafting compelling content that drives enro...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Innovate product management by leading the evolution of legacy and cloud solutions. Drive customer adoption, improve outcomes, and enhance user experience while collaborating with cross-functional tea...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Elevate your career by leading strategic ambassador and lifecycle programs. Drive enrollment growth through innovative engagement strategies while managing a dynamic team. Collaborate cross-functional...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $170K *

Pioneer innovative solutions in P&C insurance by owning the product roadmap for policy administration and commercial underwriting, integrating AI capabilities to enhance decision-making and streamline...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Accelerate progress at managing Joint Pole Committee services, leading personnel, ensuring quality and productivity, and coordinating customer deliverables while supporting program execution and issue...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$100K - $120K *

Accelerate sales growth by managing hardware and service functions across a designated territory. Drive project management and customer relationships to meet revenue and profitability goals while ensu...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Join a team that's redefining the buyer experience in B2B software. As a Principal Product Manager, you'll lead strategy, drive product delivery, and enhance buyer trust across multiple platforms, ens...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$114K - $187K *

Empower clinical studies by leading data management efforts, ensuring compliance and quality throughout the trial lifecycle. Collaborate with teams to optimize processes and enhance data integrity, me...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$142K - $177K *

Lead the charge in transforming legacy applications into modern solutions. Drive software development excellence, foster team growth, and collaborate across departments to enhance customer experiences...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $185K *

Lead client engagements in Real-World Data solutions, ensuring operational excellence and strong outcomes. Collaborate cross-functionally to translate client objectives into actionable plans, driving...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.