Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$110K - $130K *

Unlock your potential by independently managing local or regional clinical trials, ensuring adherence to budget, quality, and performance. Collaborate across teams to drive project success, enhance ef...

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Partner with us to drive strategic healthcare marketing initiatives. Lead client relationships, oversee peer-to-peer programs, and mentor team members to ensure compliance and achieve results while fo...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $270K *

Shape the future of product management by leading strategic direction for key initiatives, driving execution through cross-functional collaboration, and optimizing outcomes via data-driven insights to...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$150K - $180K *

Champion enterprise data architecture by establishing standards and a unified data catalog. Collaborate across teams to define metrics and ensure data governance, driving alignment and clarity in a ha...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$115K - $180K *

Lead the charge in managing MEP project deliverables, ensuring effective coordination, communication, and oversight of project scope, cost, and schedule for medium to large-scale data center projects...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $180K *

Innovate by leading software engineering excellence and AI adoption; manage cross-functional teams to develop impactful tech solutions while maintaining hands-on involvement with proof-of-concept proj...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Engage your expertise to lead complex HL7 integrations across healthcare systems, enhancing interoperability and data-sharing capabilities. Collaborate with stakeholders to ensure successful implement...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$93K - $127K *

Lead the charge in delivering impactful Rolling Stock Overhaul Programs, driving performance, maximizing fleet availability, and ensuring project execution to enhance rail transportation effectiveness...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Optimize our product suite to elevate financial advisory capabilities through innovative AI solutions. Lead the entire product lifecycle, collaborating with diverse teams to transform complex workflow...

United StatesRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Finance & Insurance

$210K - $240K *

Oversee strategic growth initiatives in clinical development, leveraging expertise to enhance operational delivery and client engagement. Drive innovative solutions and build strong partnerships to en...

4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$210K - $240K *

Transform the future of clinical development by leading strategic initiatives, fostering client relationships, and driving innovative solutions in a dynamic, global environment. Shape best practices a...

Durham, NCRemote

4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $150K *

Lead the charge in managing complex, technically sophisticated projects, focusing on data centers. Collaborate with diverse stakeholders to ensure project alignment with client goals, budgets, and sch...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Drive successful project delivery by leading and developing construction teams, managing execution risks, and ensuring stakeholder alignment to achieve high-quality results and team growth...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Lead project teams to deliver high-quality construction results while fostering professional growth. Oversee end-to-end project execution, manage stakeholder relationships, and ensure compliance with...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$195K - $230K *

Drive growth by leading go-to-market strategies for TMC partnerships, building and executing plans from the ground up. Collaborate cross-functionally to influence product development and represent the...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$180K - $215K *

Transform corporate engagement by leading a high-performing team to integrate nature into business strategies, driving impactful outcomes for conservation and sustainability across diverse sectors and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$150K - $258K *

Elevate your career by leading strategic initiatives in Medical and Scientific Affairs. Drive portfolio governance, enhance operational excellence, and foster cross-functional collaboration to deliver...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Empower the future of AI-driven digital products by leading strategy, portfolio management, and cross-functional collaboration to enhance user experiences and drive measurable business impact across d...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$115K - $145K *

Engineer innovative systems and processes to enhance product delivery, ensuring cross-functional teams operate efficiently and effectively. Drive execution, manage stakeholder alignment, and facilitat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Join a global team as a Senior Project Manager leading complex HVDC projects, ensuring customer satisfaction and project success through effective team management, planning, and stakeholder collaborat...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$180K - $240K *

Drive operational excellence by leading regional engineering teams, ensuring technical consistency and performance improvement across a diverse portfolio. Foster a culture of accountability and collab...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$180K - $240K *

Join a team that's redefining engineering leadership across diverse portfolios. You'll drive operational excellence, foster high-performing teams, and enhance technical consistency while ensuring sust...

Charlotte, NCRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$180K - $200K *

Manage the campaign calendar and ensure timely launches by transforming customer requests into actionable specs. Collaborate with cross-functional teams to maintain project alignment and drive success...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$122K - $177K *

Unlock potential by leading HRIS strategy and optimization, overseeing a team to enhance Workday and UKG systems. Drive transformation and collaboration across HR, Finance, and Operations for impactfu...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $140K *

Join a team that's leading high-value construction projects, overseeing all phases from pre-construction to closeout. This role emphasizes client communication, budgeting, and safety, offering signifi...

1 week ago

  •   5 - 7 years exp.  •   Staffing

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.