Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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$103K - $128K *

Join us to lead product strategy and development, driving innovation and performance in healthcare solutions. Collaborate cross-functionally to align business needs with customer expectations and ensu...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Empower your career by leading mechanical engineering projects in biopharma. Collaborate with teams to design and implement filtration and chromatography systems, ensuring compliance with industry sta...

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$160K - $175K *

Unlock your potential as a leader in training development, overseeing curriculum design and delivery. Drive continuous improvement and ensure high-quality training programs that align with operational...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$110K - $130K *

Lead complex, cross-functional initiatives by providing senior-level project and program expertise. Drive planning, implementation, and continuous improvement of health informatics processes and syste...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$118K - $140K *

Lead the charge in solid waste engineering as a Senior Project Manager, overseeing project development, managing a skilled team, and driving growth while ensuring technical excellence and client satis...

Today

  •   8 - 10 years exp.  •   Technical Services

$120K - $145K *

Deliver leadership and governance for global clinical study management, ensuring projects meet timelines and budgets while fostering collaboration and operational excellence across teams and stakehold...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$155K - $233K *

Lead the charge in transforming Supply Chain processes through digitization and AI. Oversee complex projects, ensuring alignment with objectives and budgets while fostering collaboration across teams...

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K *

Join a team that's managing environmental projects, ensuring quality and compliance while mentoring junior staff and driving business development efforts in the oil and gas sector...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$120K - $145K *

Join a team that's advancing oncology solutions by managing global clinical trials. Lead project execution from protocol development to study closeout, ensuring quality and compliance while fostering...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $185K *

Champion your career by managing groundbreaking permitting strategies for the world’s first commercial fusion power plant. Oversee environmental compliance and drive strategic engagement across federa...

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Transform complex enterprise technology programs by leading cloud, data, and analytics initiatives. Collaborate with cross-functional teams to deliver best-in-class project outcomes using Agile method...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$247K - $345K *

Unlock potential by leading enterprise-wide strategic initiatives, optimizing program execution, and enhancing technology portfolio management. Drive cross-functional collaboration and operational eff...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Consumer Technology

$140K - $170K *

Shape the success of enterprise health systems by leading full implementations. Collaborate cross-functionally to manage project lifecycles, mitigate risks, and ensure smooth transitions to customer s...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$108K - $130K *

Take ownership of commercial contract management for large-scale infrastructure projects. Ensure compliance, manage disputes, and interface with cross-functional teams to drive successful outcomes for...

4 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$75K - $109K *

Advance the future of Building Information Modeling by leading BIM strategies, ensuring model quality, and mentoring teams. Drive innovation through technology initiatives and enhance project delivery...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $125K *

Champion the development of healthcare marketing tools by guiding cross-functional teams through the product lifecycle, driving innovative features and optimizing user experiences to enhance HCP engag...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $125K *

Accelerate product innovation by leading cross-functional teams to define, develop, and launch data-driven software solutions for healthcare marketing. Influence product evolution and optimize user ex...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$113K - $210K *

Champion the future of technology audit by leading a high-performing team to deliver innovative, risk-based audit services across North America, enhancing operational efficiency and ensuring complianc...

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$161K - $210K *

Elevate workforce management by leading recruitment, onboarding, and performance strategies. Drive clinician readiness and productivity while ensuring quality care through data-driven decision-making...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$150K - $160K *

Create impactful data solutions by leading a cross-functional team in managing high-priority IT projects for federal clients. Drive collaboration and ensure project success through effective communica...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $245K *

Shape high voltage and EHV Substation and Transmission projects through effective project management and client relationship development, ensuring quality and excellence in all phases from initiation...

4 weeks ago

  •   11 - 15 years exp.  •   Technical Services

$180K - $245K *

Join our team as a Project Manager, overseeing high voltage Power Delivery projects from initiation to closeout. Foster client relationships, manage resources and budgets, and ensure project delivery...

Boston, MARemote

4 weeks ago

  •   11 - 15 years exp.  •   Technical Services

$123K - $235K *

Empower the future of bioprocessing by leading product management for the OPUS® portfolio. Drive strategy, innovation, and cross-functional collaboration to enhance customer experience and achieve bus...

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform the onboarding experience for enterprise customers by leading seamless implementations, balancing technical demands with stakeholder communication, and driving effective project management t...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$175K - $220K *

Advance your career by managing strategic biopharma alliances and projects. Collaborate with cross-functional teams to drive program execution and ensure compliance, while fostering strong partnership...

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.