Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Manager, Clinical Data Manager Study Lead
$114K - $187K *
Empower clinical studies by leading data management efforts, ensuring compliance and quality throughout the trial lifecycle. Collaborate with teams to optimize processes and enhance data integrity, me...
Reposted 3 weeks ago
Manager, Security Operations Center
$110K - $130K *
Take ownership of a 24x7 Security Operations Center, leading a team of SOC analysts. Drive performance, manage client relationships, and ensure high-quality investigations while fostering team develop...
Today
IT Manager – Supply Chain Planning and Scheduling
$125K - $135K *
Champion the design and delivery of Integrated Business Planning capabilities, bridging business planning, manufacturing, and technology. Lead a team to enhance planning processes across multiple plat...
3 weeks ago
Staff AI Organizational Architect
$150K - $180K *
Drive the technical strategy for AI across the organization, ensuring clarity and accountability in AI investments. Collaborate with cross-functional leaders to scale impactful AI initiatives, optimiz...
Reposted 3 weeks ago
$100K - $120K *
Lead a high-performing BDR team, driving strategy and accountability to achieve pipeline targets. Develop talent, refine processes, and ensure alignment with Marketing and Sales for predictable outcom...
3 weeks ago
Senior Product Manager, Sales, Marketing & Business Solutions
$140K - $175K *
Join a dynamic team to drive the strategy and roadmap for Sales and Marketing platforms, focusing on Salesforce and marketing automation. Collaborate with stakeholders to prioritize initiatives and de...
2 weeks ago
Director, Commercial CMC Programs
$150K - $180K *
Empower the execution of CMC strategies by collaborating across teams to enhance production, streamline operations, and drive commercial success for innovative therapeutics and diagnostics, ensuring a...
Reposted 6 days ago
Senior Architect, Identity and Access Management (Saviynt)
$120K - $150K *
Drive the design and implementation of innovative Identity and Access Management solutions, enhancing security and user experience across cloud and on-premises environments while leading a team of IAM...
Reposted 1 week ago
$126K - $162K *
Drive project success by leading design and construction phases, managing teams, and ensuring client satisfaction in commercial and mission-critical environments. Collaborate with stakeholders to deli...
2 weeks ago
Sr Technical Project Manager - Wireless Infrastructure (Campus & Enterprise Deployments)
$110K - $130K *
Empower your career by leading large-scale wireless infrastructure projects. Drive excellence in deployment, client relations, and cross-functional coordination while managing complex programs from co...
Today
Senior Product Manager, CRM & GTM Systems
$104K - $176K *
Champion the Lead-to-Opportunity domain by driving product strategy, mentoring analysts, and enhancing the GTM tech stack. Influence the roadmap and ensure seamless lead conversion while collaborating...
3 weeks ago
SENIOR KNOWLEDGE MANAGEMENT ANALYST
$87K - $135K *
Unlock your potential by leading a dynamic Knowledge Management program that enhances IT support services, fosters collaboration, and drives efficiency for a large-scale enterprise environment. Make a...
1 week ago
Senior Product Manager, AI Products & Commercialization| US: Remote
$150K - $159K *
Drive the transformation of AI agent capabilities into scalable, revenue-generating products. Collaborate across teams to define strategies, evaluate opportunities, and lead product commercialization...
Yesterday
Product Owner, P&C Policy & Commercial Underwriting
$110K - $170K *
Pioneer innovative solutions in P&C insurance by owning the product roadmap for policy administration and commercial underwriting, integrating AI capabilities to enhance decision-making and streamline...
2 weeks ago
Staff Product Manager (Product-Led Growth)
$130K - $160K *
Elevate the developer journey by driving growth in the self-serve funnel and shaping the product strategy. Collaborate cross-functionally to create a data-driven experience while building vital system...
Reposted 3 weeks ago
Communications & Change Management Lead - Strategic Supplier Program
$110K - $130K *
Unlock potential by leading change management and communication strategies for a large-scale supplier sourcing transformation, ensuring stakeholder engagement and seamless adoption across teams and su...
Today
Executive Operational Planning Director
$114K - $218K *
Drive strategic operational planning and execution, ensuring clarity and momentum for executive leadership. Collaborate across teams to deliver high-quality materials and insights, enabling informed d...
Today
$115K - $130K *
Lead the Archibus platform for a major Life Sciences client, driving enhancements and integrations while ensuring data integrity and user satisfaction. Collaborate with cross-functional teams to optim...
5 days ago
$142K - $213K *
Join a team that's shaping the future of project execution in Power Systems. Lead diverse teams, drive operational excellence, and ensure project success across the U.S. while fostering collaboration...
2 days ago
$88K - $147K *
Lead the charge in operational excellence by managing a dynamic Facility Services team, enhancing customer experience, and driving business growth through effective service delivery and continuous imp...
6 days ago
Senior Manager, Solutions Engineer (FSI)
$220K - $330K *
Unlock potential by leading high-performing solution engineering teams in Financial Services. Drive pre-sales strategies, mentor talent, and enhance customer experiences through innovative AI solution...
4 weeks ago
$75K - $130K *
Lead the charge in enhancing risk management strategies by collaborating with stakeholders, optimizing GRC technology, and driving data-driven decision-making to support organizational goals in a dyna...
Today
$80K - $95K *
Join a team that's dedicated to delivering exceptional commercial construction projects, from planning through closeout, expertly navigating timelines and budgets while fostering strong client relatio...
Reposted 3 weeks ago
$120K - $145K *
Shape the future of digital transformation by leading a dynamic team to deliver innovative solutions that enhance business efficiency and customer experience across multi-functional AWS programs...
6 days ago
Engineering Operations Project Manager
$80K - $95K *
Oversee a team managing mechanical and electrical operations across facilities. Drive maintenance, support budgeting, and ensure compliance with engineering standards while fostering staff development...
1 week ago
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.