Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Manager, Supplier Development Engineering - Special Process & Mechanical Assembly
$146K - $215K *
Elevate supplier performance by leading a team focused on manufacturing excellence, capacity readiness, and strategic improvement initiatives to support business growth and operational maturity across...
2 weeks ago
Manager, Supplier Development Engineering - Special Process & Mechanical Assembly
$146K - $215K *
Elevate your career by leading supplier development initiatives, enhancing manufacturing capabilities, and driving operational excellence. Collaborate cross-functionally to ensure supplier readiness a...
2 weeks ago
$175K - $185K *
Unlock potential by leading global product strategies that drive growth and innovation. Collaborate cross-functionally to prioritize customer needs, enhance product performance, and support internatio...
Today
HR Technology Sr. Project Manager
$100K - $120K *
Drive successful HR technology projects by managing implementations and enhancements across global teams. Utilize strong organizational skills to oversee multiple projects, ensuring timely delivery an...
3 weeks ago
Director, AI Platforms & Engineering
$105K - $165K *
Shape the future of AI platforms by leading strategy, architecture, and engineering for scalable, secure solutions. Drive innovation while ensuring compliance and operational excellence across enterpr...
6 days ago
$135K - $160K *
Help us shape the future of pulmonary care by leveraging your clinical expertise to drive product development, enhance workflows, and ensure effective solutions for COPD, asthma, and other pulmonary c...
1 week ago
$146K - $189K *
Partner with us to enhance our community health provider network. Leverage your expertise in provider relations and network management to drive growth, improve access to care, and support our mission...
2 weeks ago
Director, Product Strategy & Monetization
$185K - $255K *
Transform the financial engine of R&D by leading revenue strategies, pricing, and cost management. Collaborate with senior leaders to align short-term goals with long-term product vision, while buildi...
2 weeks ago
$135K - $160K *
Lead a dynamic team to transform AI strategies into impactful healthcare solutions. Oversee engineering execution, guide architecture, and ensure compliance while collaborating with cross-functional p...
Today
Product Manager II - Agentic Platform
$110K - $130K *
Play a key role in driving platform innovation by managing product specs, collaborating closely with engineering on structured development, and ensuring user feedback shapes future capabilities for in...
4 weeks ago
Senior Product Manager, Integrations & Platform
$175K - $190K *
Innovate the deployment process by leading two squads to ensure seamless integration and self-service capabilities for customers, driving measurable outcomes and enhancing product effectiveness in a d...
1 week ago
$80K - $95K *
Transform project execution by leading change management initiatives and IT services. Collaborate with government stakeholders to ensure alignment with policies while driving strategic projects to suc...
Today
Software Engineering Program Manager
$120K - $145K *
Elevate your career by managing technical programs across global engineering teams. Drive alignment, enhance decision-making, and leverage AI to optimize workflows while supporting senior leadership i...
2 days ago
$100K - $135K *
Unlock potential by leading project controls for complex projects. Oversee planning, cost management, and risk assessment while mentoring a team to ensure timely, budget-compliant project delivery in...
1 week ago
Program Director, Professional Services
$180K - $200K *
Accelerate progress at regional Professional Services by leading teams, driving growth and quality in consulting engagements while fostering strategic partnerships and developing innovative service of...
Reposted 2 weeks ago
$110K - $130K *
Elevate global post-market surveillance by leading a team focused on safety, compliance, and performance of medical devices. Drive field actions, analyze data, and collaborate cross-functionally to en...
1 week ago
Director, Business and Data Analytics
$164K - $314K *
Unlock your potential by leading strategic data initiatives that drive business success. Collaborate with cross-functional teams to enhance analytics capabilities and deliver actionable insights, shap...
1 week ago
Director, Quantitative Systems Pharmacology
$188K - $313K *
Lead the charge in advancing quantitative systems pharmacology through innovative modeling and simulation strategies, driving integration across drug discovery and development to enhance patient outco...
1 week ago
$171K - $245K *
Champion the strategic product lifecycle for healthcare solutions, driving innovation and collaboration across teams to enhance patient access and streamline workflows. Deliver measurable outcomes tha...
Yesterday
Procurement Manager, Process & Policy
$93K - $159K *
Advance your career by developing and standardizing Procurement processes that enhance compliance and efficiency. Collaborate with cross-functional teams to create clear documentation and governance p...
6 days ago
Implementation Manager - Data Solutions
$91K - $145K *
Shape the future of data solutions by leading complex pharmacy claims and physician-level data integrations. Collaborate with cross-functional teams to deliver high-quality, scalable solutions that me...
3 weeks ago
Senior Manager, Global Meeting Planning
$145K - $168K *
Drive impactful medical congress operations by leading planning, execution, and cross-functional collaboration. Own vendor relationships and budgets while ensuring compliance and delivering high-quali...
2 weeks ago
Senior Technical Product Manager
$153K - $213K *
Champion the development of a key platform, driving strategy, success metrics, and technical depth while collaborating across teams to deliver impactful solutions that meet customer needs and enhance...
3 weeks ago
Project Controls Managers & Directors - Project Farma
$99K - $199K *
Join a dynamic team to lead project controls in life sciences, enhancing project delivery through data-driven insights and collaboration. Drive excellence in cost, schedule, and performance management...
2 days ago
Project Controls Managers & Directors - Project Farma
$99K - $199K *
Join a team that's dedicated to enhancing patient lives by leading project controls for biomanufacturing. Collaborate with cross-functional teams to deliver high-quality life sciences projects while m...
2 days ago
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.