Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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1,000+

Director, Program Management Jobs in North Carolina

Sort By: Relevance

$146K - $215K *

Elevate supplier performance by leading a team focused on manufacturing excellence, capacity readiness, and strategic improvement initiatives to support business growth and operational maturity across...

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$146K - $215K *

Elevate your career by leading supplier development initiatives, enhancing manufacturing capabilities, and driving operational excellence. Collaborate cross-functionally to ensure supplier readiness a...

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$175K - $185K *

Unlock potential by leading global product strategies that drive growth and innovation. Collaborate cross-functionally to prioritize customer needs, enhance product performance, and support internatio...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Drive successful HR technology projects by managing implementations and enhancements across global teams. Utilize strong organizational skills to oversee multiple projects, ensuring timely delivery an...

3 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$105K - $165K *

Shape the future of AI platforms by leading strategy, architecture, and engineering for scalable, secure solutions. Drive innovation while ensuring compliance and operational excellence across enterpr...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$135K - $160K *

Help us shape the future of pulmonary care by leveraging your clinical expertise to drive product development, enhance workflows, and ensure effective solutions for COPD, asthma, and other pulmonary c...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$146K - $189K *

Partner with us to enhance our community health provider network. Leverage your expertise in provider relations and network management to drive growth, improve access to care, and support our mission...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$185K - $255K *

Transform the financial engine of R&D by leading revenue strategies, pricing, and cost management. Collaborate with senior leaders to align short-term goals with long-term product vision, while buildi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Lead a dynamic team to transform AI strategies into impactful healthcare solutions. Oversee engineering execution, guide architecture, and ensure compliance while collaborating with cross-functional p...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Play a key role in driving platform innovation by managing product specs, collaborating closely with engineering on structured development, and ensuring user feedback shapes future capabilities for in...

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $190K *

Innovate the deployment process by leading two squads to ensure seamless integration and self-service capabilities for customers, driving measurable outcomes and enhancing product effectiveness in a d...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Transform project execution by leading change management initiatives and IT services. Collaborate with government stakeholders to ensure alignment with policies while driving strategic projects to suc...

Today

  •   Less than 5 years exp.  •   Real Estate & Construction

$120K - $145K *

Elevate your career by managing technical programs across global engineering teams. Drive alignment, enhance decision-making, and leverage AI to optimize workflows while supporting senior leadership i...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $135K *

Unlock potential by leading project controls for complex projects. Oversee planning, cost management, and risk assessment while mentoring a team to ensure timely, budget-compliant project delivery in...

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$180K - $200K *

Accelerate progress at regional Professional Services by leading teams, driving growth and quality in consulting engagements while fostering strategic partnerships and developing innovative service of...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate global post-market surveillance by leading a team focused on safety, compliance, and performance of medical devices. Drive field actions, analyze data, and collaborate cross-functionally to en...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$164K - $314K *

Unlock your potential by leading strategic data initiatives that drive business success. Collaborate with cross-functional teams to enhance analytics capabilities and deliver actionable insights, shap...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$188K - $313K *

Lead the charge in advancing quantitative systems pharmacology through innovative modeling and simulation strategies, driving integration across drug discovery and development to enhance patient outco...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$171K - $245K *

Champion the strategic product lifecycle for healthcare solutions, driving innovation and collaboration across teams to enhance patient access and streamline workflows. Deliver measurable outcomes tha...

Yesterday

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$93K - $159K *

Advance your career by developing and standardizing Procurement processes that enhance compliance and efficiency. Collaborate with cross-functional teams to create clear documentation and governance p...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$91K - $145K *

Shape the future of data solutions by leading complex pharmacy claims and physician-level data integrations. Collaborate with cross-functional teams to deliver high-quality, scalable solutions that me...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$145K - $168K *

Drive impactful medical congress operations by leading planning, execution, and cross-functional collaboration. Own vendor relationships and budgets while ensuring compliance and delivering high-quali...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$153K - $213K *

Champion the development of a key platform, driving strategy, success metrics, and technical depth while collaborating across teams to deliver impactful solutions that meet customer needs and enhance...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$99K - $199K *

Join a dynamic team to lead project controls in life sciences, enhancing project delivery through data-driven insights and collaboration. Drive excellence in cost, schedule, and performance management...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$99K - $199K *

Join a team that's dedicated to enhancing patient lives by leading project controls for biomanufacturing. Collaborate with cross-functional teams to deliver high-quality life sciences projects while m...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.