Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
$211K - $272K *
Transform your career by leading enterprise applications strategy and delivery. Collaborate with cross-functional teams to enhance processes, drive AI adoption, and ensure robust application architect...
Today
$95K - $115K *
Shape operational excellence by leading a dynamic team in materials planning and execution for Engineered-to-Order manufacturing, ensuring timely delivery and optimal resource utilization while foster...
3 weeks ago
Senior Technical Project Manager - Software Development
$138K - $180K *
Shape the future of medical device development by driving project execution, collaboration, and innovation within a dynamic Research & Development team focused on enhancing healthcare outcomes and pat...
Reposted 5 days ago
Director, SAP S/4HANA Solution Architect
$160K - $240K *
Shape the future of enterprise solutions by architecting and governing SAP S/4HANA Retail transformations. Lead a team to design integrated systems that enhance operational excellence and drive busine...
2 days ago
$150K - $180K *
Join a team that's redefining scientific data management in drug discovery. Lead the scientific data team, bridging scientists and engineers to ensure data integrity, quality, and innovative solutions...
2 weeks ago
Senior Project Manager Product
$110K - $130K *
Shape the future of product development by leading cross-functional teams to deliver innovative solutions from concept to launch, ensuring alignment with business goals and quality standards...
1 week ago
Associate Medical Director, Global Safety Physician
$184K - $253K *
Drive global pharmacovigilance efforts by managing safety data, leading clinical development strategies, and collaborating across teams to enhance product safety and efficacy throughout their lifecycl...
Today
$100K - $135K *
Lead the charge in delivering complex projects from initiation to close, ensuring alignment among stakeholders, effective risk management, and adherence to timelines while utilizing AI tools to enhanc...
3 weeks ago
$160K - $201K *
Lead the charge in shaping and evolving a global web ecosystem, overseeing strategy, operations, and governance to deliver high-performing digital experiences that drive engagement and business growth...
2 weeks ago
Senior Product Manager, Provider Experience
$170K - $220K *
Drive product strategy and development to enhance clinician experience, optimizing patient care through innovative solutions and stakeholder collaboration across a nationwide healthcare network...
1 week ago
Director, Strategic Initiatives
$149K - $205K *
Elevate innovation at the forefront of foodtech, agritech, and infrastructure. Lead strategic initiatives, build ecosystems, and drive new ventures to shape the future landscape of Mitsubishi Electric...
6 days ago
Director, Leadership & People Development
$120K - $150K *
Lead the charge in talent and leadership development, driving innovative programs that evolve with our growth. Shape the future of workforce readiness while enhancing AI fluency and fostering impactfu...
1 month ago
$100K - $150K *
Lead the charge in managing complex, technically sophisticated projects, focusing on data centers. Collaborate with diverse stakeholders to ensure project alignment with client goals, budgets, and sch...
Reposted yesterday
$188K - $245K *
Drive innovative UX design strategies in clinical settings, leading a talented team to enhance decision support and care coordination. Collaborate across functions to integrate AI and elevate user exp...
4 weeks ago
Digital Product Manager - Data Security
$120K - $193K *
Transform enterprise security by leading product strategy and delivery, focusing on data protection and compliance. Drive innovation through AI integration, ensuring scalable solutions that meet evolv...
1 week ago
Product Manager - Vendor Oversight
$113K - $197K *
Lead the charge in defining product strategy and roadmap, translating business objectives into actionable plans. Collaborate with cross-functional teams to ensure successful implementation and operati...
1 week ago
$86K - $124K *
Champion the future of project management by leading SAP initiatives, driving agile practices, and delivering innovative solutions that meet client needs while fostering team collaboration and continu...
6 days ago
$85K - $124K *
Drive impactful SAP projects as a Project Manager/Scrum Master, leading teams to deliver innovative solutions. Collaborate with stakeholders, manage product backlogs, and ensure agile practices to mee...
Today
Director, Business Development & Capture
$125K - $150K *
Join a dynamic team to lead complex capture efforts, engaging with federal and commercial markets. Leverage your Special Operations expertise to shape mission-critical opportunities and ensure discipl...
Reposted 1 week ago
Director, Supply Chain Operations
$125K - $150K *
Join a dynamic team to optimize supply chain operations, ensuring efficient medication delivery from pharmacy partners to patients. Oversee systems, processes, and a team to scale operations amidst ra...
Reposted 1 week ago
$115K - $168K *
Lead the charge in federal grant management for the 988 Suicide & Crisis Lifeline, overseeing compliance, budgeting, and operations. Collaborate across teams to ensure effective grant administration a...
3 weeks ago
Senior Manager, Clinical Lab Project Management
$134K - $219K *
Lead clinical laboratory operations for precision medicine projects, ensuring timely deliverables and risk management across therapeutic areas. Collaborate with cross-functional teams to support clini...
3 weeks ago
$150K - $180K *
Innovate and lead the MyGeotab workflows, ensuring usability and reliability while driving evolution and collaboration across product domains to enhance customer experience and operational efficiency...
Reposted 1 week ago
$95K - $115K *
Transform client relationships by managing pharmaceutical programs, overseeing staff, and ensuring operational excellence. Collaborate with stakeholders to enhance program performance while adhering t...
Yesterday
Senior Director, Client Success
$150K - $180K *
Reimagine client partnerships by managing complex relationships, driving performance, and leading recovery strategies. Collaborate with executives to ensure client success and identify growth opportun...
2 weeks ago
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.