Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$140K - $184K *
Pioneer the development and operational convergence through automation, designing CI/CD pipelines and driving release process efficiency to enhance software delivery across diverse teams and projects...
Reposted today
$150K - $180K *
Champion growth by leading regional sales across diverse markets while developing a top-performing team of Account Executives. Drive sales strategies, forge strong partnerships, and elevate enterprise...
Reposted 3 weeks ago
Solution Advisory Senior Manager - Enterprise Performance & Productivity
$132K - $338K *
Shape enterprise performance by leading strategic initiatives that drive productivity and cost transformation. Collaborate with senior stakeholders to develop tailored solutions that enhance client va...
1 week ago
Senior Software Engineer, AI Developer Experience
$135K - $160K *
Lead the charge in building AI-powered engineering systems that enhance developer workflows, ensuring reliability and ease of adoption for engineers. Collaborate with teams to create innovative soluti...
1 week ago
Facility Coding Quality Integrity Analyst - Inpatient
$73K - $110K *
Shape the future of coding quality by overseeing audits, developing guidance, and collaborating with teams to enhance accuracy and compliance in healthcare coding practices...
1 week ago
$100K - $130K *
Support the financial planning and analysis for Executive Leadership, encompassing budgeting, forecasting, and reporting. Collaborate cross-functionally to drive profitability through data-driven insi...
Reposted 2 weeks ago
Senior Strategic Marketing Manager | East Coast | Remote
$160K - $195K *
Join a team that's redefining account marketing for major clients. Collaborate with cross-functional partners to drive growth, enhance customer engagement, and create tailored marketing strategies tha...
5 days ago
AWS Cloud-Native Solution Architect Associate Director
$150K - $375K *
Innovate cutting-edge AWS solutions by leading technical sales, crafting proposals, and collaborating with teams to deliver transformative cloud strategies that meet client needs and drive business su...
2 days ago
AWS Cloud-Native Solution Architect Associate Director
$150K - $375K *
Unlock potential by leading AWS cloud solutions, driving technical sales, and collaborating with teams to deliver innovative, client-focused outcomes. Your expertise will shape proposals and presentat...
4 days ago
Senior Staff Engineer, Design Systems
$135K - $160K *
Join a dynamic team to architect and implement a next-gen Design System, ensuring consistent, accessible experiences across products. Collaborate with cross-functional teams to drive technical alignme...
1 week ago
Lead Front-End Engineer (React, TypeScript and MUI)
$120K - $140K *
Lead a dynamic team to design and develop innovative front-end solutions using React and TypeScript. Mentor engineers, drive technical direction, and ensure high-quality software delivery in a collabo...
1 week ago
Portfolio Design, Analytics, & Risk Principal
$126K - $252K *
Unlock innovative investment strategies by conducting risk assessments and performance analysis. Collaborate with top teams to enhance methodologies and drive informed decisions, showcasing expertise...
Reposted 5 days ago
Director, Software Engineering (Account Servicing & Finance)
$150K - $180K *
Unlock potential by leading software engineering teams to deliver scalable solutions. Drive strategic partnerships, enhance engineering practices, and foster a culture of innovation and accountability...
Yesterday
$71K - $125K *
Transform client relationships by supporting sales and credit functions, managing lending processes under $10M, and ensuring data integrity. Collaborate with teams to create impactful pitch materials...
Yesterday
Life Sciences Finance Reinvention Partner - Consultant
$59K - $177K *
Drive finance transformation in Life Sciences by enhancing processes, data, and technology. Collaborate with leaders to improve efficiency, manage costs, and identify opportunities, leveraging analyti...
Today
$61K - $104K *
Engage in impactful public health data analysis, utilizing quantitative skills and epidemiological knowledge to enhance surveillance programs and support critical health initiatives...
Reposted today
Senior Director of Engineering
$261K - $308K *
Transform Women's Health engineering by leading a high-impact team to deliver innovative software solutions. Collaborate across functions to shape strategy and drive organizational excellence while en...
5 days ago
Software Engineer III, iOS - Cal AI
$135K - $165K *
Engage with our Cal AI team to enhance user experiences through innovative iOS development. Collaborate, mentor, and implement high-quality features that empower users on their health journeys while f...
2 weeks ago
$163K - $322K *
Unlock potential by leading Finance Transformation initiatives, managing project deliverables, and collaborating with cross-functional teams to implement Anaplan solutions. Coach junior members and dr...
2 weeks ago
Interventional Clinical Consultant-East
$110K - $130K *
Serve as a clinical and technical leader, influencing decision-makers and supporting product innovation in interventional healthcare. Engage with key stakeholders and showcase advanced solutions to en...
6 days ago
Staff Bioinformatics Engineer, Clinical Applications
$134K - $179K *
Lead the charge in bridging genomic variants with clinical insights, collaborating with scientists to automate and scale curation workflows. Drive innovation in AI/ML applications while ensuring softw...
2 weeks ago
$120K - $170K *
Transform enterprise software systems by leading design and development efforts, ensuring scalable, secure applications that meet federal mission needs while mentoring engineers and driving best pract...
1 week ago
$96K - $111K *
Drive the administration and analysis of employee benefits programs, ensuring compliance and enhancing the associate experience. Collaborate with HR and external vendors to manage health, retirement...
Today
$80K - $133K *
Innovate with us to deliver AI and machine learning solutions that transform data into actionable insights. Collaborate across teams to enhance fraud detection and anomaly analysis, leveraging advance...
2 weeks ago
Sr. Analyst, External Reporting
$80K - $95K *
Unlock potential by serving as a global expert in financial reporting, overseeing SEC filings and internal controls to enhance the integrity of consolidated financial statements, while collaborating w...
Reposted 1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.