Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Enterprise Account Executive, Corporate
$105K - $140K *
Grow your career with a dynamic sales role focused on Fortune 1000 clients. Drive new business, manage account strategies, and collaborate with teams to achieve sales success in a fast-paced, high-gro...
Today
Sr/Staff Frontend Engineer | Web Products
$200K - $250K *
Drive impactful frontend solutions, transforming complex requirements into user-centric, performant interfaces. Collaborate closely with cross-functional teams to enhance the healthcare experience for...
Reposted 4 days ago
Structural Engineering Consultant 2 - Nuclear
$145K - $222K *
Lead a structural engineering team, guiding projects for nuclear facilities. Utilize your expertise in design and analysis while collaborating with clients and multidisciplinary teams to deliver innov...
1 week ago
Principal Technologist - AI Compute
$160K - $200K *
Elevate your career as a Principal Technologist, leading AI compute infrastructure solutions in pre-sales. Collaborate with top-tier clients, drive innovative designs, and influence strategic engageme...
1 week ago
$120K - $145K *
Elevate your career by leading cloud infrastructure design and automation. As a senior technical leader, you'll mentor engineers, optimize systems, and ensure robust, secure solutions for clients whil...
Today
Director, Pricing and Profitability
$124K - $223K *
Shape the future of pricing strategy by leading a dynamic team to optimize profitability and drive strategic decisions across SaaS and services. Collaborate with executives to enhance customer value a...
3 weeks ago
Lead Forward Deployed Engineer - AWS
$189K - $372K *
Inspire innovation as a senior practitioner leading GenAI solutions for strategic clients. Collaborate with C-suite leaders, drive technical direction, and mentor teams in hybrid delivery environments...
Reposted 3 weeks ago
Lead Forward Deployed Engineer - AWS
$189K - $372K *
Build impactful GenAI solutions as a senior leader, collaborating with clients and engineering teams. Direct pods to ensure effective delivery and influence executive decisions for successful project...
Reposted 3 weeks ago
$114K - $252K *
Transform the enterprise AI landscape by architecting innovative cloud solutions, enabling optimized workflows across government services, and driving team excellence in AI development and integration...
Reposted 2 weeks ago
Ecosystem Operations Specialist
$86K - $146K *
Join us to execute and enhance partner operations, ensuring seamless workflows and data integrity. Collaborate with cross-functional teams to support sales and partners, driving efficiency and operati...
1 week ago
Director, Professional Services (Data Migration & Conversion and AI & Automation)
$150K - $180K *
Transform global data migration and AI automation strategies, leading teams to enhance delivery quality and customer value. Drive innovation, operational excellence, and scalable methodologies while f...
Today
SAP Principal Pre-Sales & Delivery Architect
$150K - $180K *
Join us to lead solution direction across multiple SAP engagements, ensuring customer value and platform adoption. Collaborate with teams to shape proposals, drive delivery, and influence product deve...
Today
Senior Capture Manager Consultant
$120K - $160K *
Empower your career by leading strategic capture efforts to secure significant business opportunities. Collaborate with cross-functional teams to develop winning strategies and drive successful bid su...
Today
$135K - $160K *
Transform product security by leading strategy, conducting threat modeling, and collaborating across teams to ensure secure design and compliance. Drive innovation in security practices while mentorin...
3 weeks ago
$101K - $152K *
Lead the charge in ensuring product excellence by overseeing quality assurance processes, conducting audits, and collaborating with cross-functional teams to enhance product quality and exceed custome...
1 week ago
Principal Architect - Data Centers
$125K - $200K *
Join a team that's redefining architectural excellence by leading global projects, driving business growth, and fostering client relationships while overseeing studio operations and strategic initiati...
2 days ago
$78K - $156K *
Join a team that's dedicated to enhancing business systems through design, configuration, and support. As a Senior Application Analyst, you'll lead improvements, mentor junior analysts, and ensure sea...
3 weeks ago
$110K - $130K *
Engage in the design and management of enterprise endpoint technologies, ensuring security and efficiency across over 1,000 devices. Collaborate with cross-functional teams to enhance endpoint perform...
3 weeks ago
Clinical Research Associate II
$90K - $110K *
Unlock potential by overseeing clinical trials, ensuring compliance with protocols and regulations. Collaborate with investigators and coordinators to protect participant rights and verify data integr...
1 week ago
$90K - $110K *
Analyze and optimize public health programs by coordinating project activities, evaluating operational enhancements, and ensuring compliance with regulatory standards to improve health outcomes for af...
2 days ago
$95K - $115K *
Drive IT operations and support in a fast-growing environment, enhancing processes and automating workflows. Collaborate with cross-functional teams to scale IT infrastructure as the company expands f...
Today
$95K - $115K *
Join a team that's redefining recruitment by driving innovative strategies, partnering with leaders, and enhancing candidate experiences. You'll own full-cycle recruiting and lead diverse searches in...
Yesterday
Senior Manager, AWS Full Stack AI Engineering
$124K - $280K *
Drive innovation by leading multidisciplinary teams in AWS Full Stack AI Engineering, shaping cloud-native solutions, and guiding strategic client conversations throughout the software development lif...
2 weeks ago
Senior Manager, AWS Full Stack AI Engineering
$124K - $280K *
Transform multidisciplinary teams by leading AWS full stack AI engineering projects, guiding technical delivery, and shaping cloud-native solutions to meet client needs across the software development...
2 weeks ago
$160K - $185K *
Join a team that's transforming customer experiences through innovative technical solutions. As a Solutions Architect, you'll bridge business needs with technology, guiding clients from discovery to d...
6 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.