Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Software Engineer- Rust / C++
$94K - $176K *
Drive innovation in document processing by leading high-impact projects, shaping architecture, and optimizing performance in a queue-driven pipeline. Collaborate across teams to enhance AI products an...
2 weeks ago
$120K - $145K *
Unlock potential by leading pre-sales technical strategies that align solutions with client needs, driving revenue growth and retention through collaboration with sales teams and delivering tailored p...
5 days ago
Technical Program Manager, Data Center Operations
$120K - $145K *
Engage in comprehensive program management for data center operations, ensuring seamless transitions from construction to live operations. Shape maintainability, drive incident improvements, and enhan...
Reposted today
Principal Data Architect Job Details | curium
$130K - $155K *
Lead the design and governance of enterprise data architecture to enhance business intelligence, analytics, and digital transformation. Collaborate with stakeholders to ensure data alignment with stra...
2 weeks ago
Senior Software Engineer - REMOTE
$120K - $170K *
Lead the development of scalable systems, balancing individual contributions with technical guidance. Collaborate across teams to tackle complex engineering challenges in security and AI, while evolvi...
2 weeks ago
Senior Consultant, Oracle EPM Cloud
$125K - $150K *
Unlock your potential as you drive Oracle EPM Cloud Planning solutions, supporting clients in their transformations. Leverage your expertise to configure, implement, and coach while enhancing project...
Reposted 2 weeks ago
$80K - $90K *
Champion data integrity by cleaning and enriching restaurant accounts at scale. Utilize AI and automation tools to streamline processes, ensuring accurate insights for sales teams while maintaining hi...
Today
$110K - $130K *
Optimize operational excellence by enhancing system reliability and automating processes. Leverage your expertise in AWS and cloud technologies to ensure high availability and performance of mission-c...
1 week ago
$100K - $145K *
Shape the future of technical delivery by leading client engagements, setting standards, and mentoring teams in AI-driven Salesforce solutions, ensuring quality and integration across Marketing Cloud...
5 days ago
$110K - $130K *
Join a team that's dedicated to enhancing system reliability and performance. You'll drive automation and continuous improvement initiatives, ensuring high availability and minimal downtime for missio...
1 week ago
$210K - $230K *
Drive your career with a dynamic role focused on enterprise B2B sales, where you'll cultivate relationships, leverage data insights, and collaborate cross-functionally to close high-value deals in a f...
5 days ago
Account Executive - Integrator Sales
$95K *
Join a team that's driving growth by managing key Integrator accounts, developing sales strategies, and fostering relationships to exceed corporate goals in the material handling industry...
3 weeks ago
$150K - $180K *
Unlock potential by driving complex sales into Fortune 2000 accounts, engaging with key stakeholders in compliance and technology. Shape the future of AI in enterprise solutions while achieving ambiti...
1 week ago
Global Account Executive - Life Sciences | Luma
$150K - $180K *
Unlock potential by driving digital transformation in Life Sciences. Engage with CxOs and R&D teams to deliver innovative SaaS solutions, navigate complex sales cycles, and build lasting partnerships...
3 weeks ago
Architect - Platform Engineering - USA
$150K - $180K *
Join a dynamic team to architect and implement cutting-edge MLOps strategies, leveraging Google Cloud's AI/ML stack. Drive innovation in model lifecycle management and collaborate with cross-functiona...
1 week ago
Sr. Manager, Enterprise Customer Success - Select
$125K - $169K *
Transform customer outcomes by leading a high-performing team dedicated to leveraging Samsara's solutions. Drive strategic growth while ensuring enterprise clients realize sustained value from their i...
Reposted 1 week ago
Lead Application Modernization Consultant
$125K - $168K *
Pioneer application modernization efforts by leading agile teams, driving technical outcomes, and enhancing developer experiences. Collaborate with clients to deliver measurable business results while...
6 days ago
Senior Engineer, Mission Planning
$120K - $145K *
Innovate in mission planning by developing autonomous operations for satellite constellations. Collaborate with cross-functional teams to define requirements, prototype code, and optimize algorithms...
3 weeks ago
$80K - $90K *
Shape the future of integrated marketing strategies by owning the creative process from ideation to execution. Collaborate with teams to deliver impactful campaigns that drive performance and renewals...
Yesterday
Account Executive - Compliance Sales
$88K - $150K *
Shape the future of cybersecurity by driving growth in strategic accounts. Leverage your expertise to build executive relationships, navigate complex sales cycles, and expand our compliance audit and...
2 weeks ago
Director, AWS AI Application Engineering
$155K - $410K *
Join a team that's redefining AWS-native application engineering. As a Director, you'll lead innovative projects, shape client relationships, and drive strategic initiatives across the software delive...
2 weeks ago
Director, AWS AI Application Engineering
$155K - $410K *
Lead the design and modernization of AWS-native applications, guiding teams through architecture decisions and client relationships while driving AI-enabled engineering and strategic growth across mul...
2 weeks ago
Staff Engineer, Project Engineering
$110K - $130K *
Optimize manufacturing capabilities by managing capital projects up to $5MM. Collaborate with cross-functional teams to ensure compliance with GMP standards and drive project success through effective...
Reposted 2 days ago
Infrastructure Architecture Manager
$110K - $130K *
Join a dynamic team to design and optimize enterprise infrastructure, leading initiatives in network architecture, virtualization, and cloud services while ensuring reliability and security across sys...
5 days ago
$110K - $130K *
Elevate client outcomes by managing complex AI and data programs. Serve as the primary contact for multi-geo teams, ensuring technical delivery aligns with business goals. Foster strong relationships...
Reposted 3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.