Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$70K - $126K *
Analyze program outcomes and collaborate with stakeholders to enhance results. Manage complex projects, provide insights to leadership, and educate agencies on best practices to optimize performance a...
Reposted 2 days ago
Senior Infrastructure & Platform Engineer
$130K - $175K *
Engineer and optimize enterprise platforms for diverse environments, ensuring seamless deployment and support. Collaborate with clients to enhance cybersecurity, compliance, and observability solution...
Reposted 3 days ago
$150K - $180K *
Shape the future of enterprise sales by driving innovation and closing deals. Collaborate with key stakeholders to expand customer vision and exceed revenue targets while managing complex sales cycles...
Reposted today
$150K - $180K *
Drive enterprise sales by closing new and existing accounts, leveraging deep product knowledge and customer relationships to exceed revenue targets and deliver innovative solutions in the big data and...
Reposted 4 days ago
Senior Technical Program Manager
$120K - $145K *
Lead the delivery of complex AI-native security initiatives, bridging AI research and security operations. Drive cross-functional programs, manage risks, and ensure compliance while communicating effe...
3 days ago
Senior Regulatory Affairs Associate - Regulatory Intelligence
$95K - $115K *
Drive regulatory intelligence initiatives to ensure compliance and support clinical research. Collaborate with experts to assess regulatory changes, track global guidelines, and enhance impact assessm...
1 week ago
$130K - $225K *
Join a team that's pioneering AI capabilities by designing, building, and deploying production-ready AI solutions. Collaborate with cross-functional teams to integrate advanced technologies into a sec...
3 days ago
Senior Applications Security Engineer, AI & Automation Development
$87K - $161K *
Optimize automation and AI capabilities within Security Defense Technologies. Collaborate with teams to design AI solutions, enhance Kubernetes operations, and implement secure development practices t...
Today
$63K - $111K *
Elevate project execution by supporting engineering and construction teams in delivering complex industrial infrastructure projects through technical coordination and quality assurance activities...
1 week ago
$90K - $102K *
Contribute to the development and maintenance of secure, scalable solutions in Microsoft 365 and Azure. Collaborate with teams to enhance automation, identity security, and API integrations, ensuring...
5 days ago
Senior Cloud Operations Engineer
$120K - $145K *
Transform your career by owning AWS cloud operations, enhancing reliability, performance, and cost efficiency. Collaborate with cross-functional teams to ensure seamless service delivery and operation...
1 week ago
$162K - $238K *
Design and optimize R&D operations to enhance organizational effectiveness through data-driven insights, collaboration, and governance. Partner cross-functionally to drive continuous improvement and e...
Reposted today
Senior Technology Portfolio Manager
$115K - $159K *
Lead strategic technology initiatives by overseeing portfolio management, execution, and governance. Collaborate with stakeholders to align enterprise goals, enhance delivery outcomes, and develop pro...
Today
Talent & Workforce Industry & Process Advisor Manager, Banking
$94K - $293K *
Unlock potential by leading transformative talent strategies that integrate AI and workforce analytics. Drive innovation in talent processes, enhance client relationships, and shape the future of work...
1 week ago
Implementation Manager, Financial Services
$100K - $120K *
Accelerate client success by owning the onboarding and rollout for enterprise clients, ensuring smooth transitions from purchase to sustained usage. Collaborate with cross-functional teams to drive ad...
5 days ago
Senior Manager, Lifecycle Marketing
$181K - $245K *
Elevate your career by leading lifecycle marketing strategies that enhance customer engagement, retention, and monetization. Drive impactful programs while managing a high-performing team and collabor...
1 week ago
Strategic Account Executive - AI, San Francisco
$124K - $186K *
Empower enterprise growth by driving strategic account management for AI-native companies, guiding complex transformations, and fostering long-term partnerships through innovative DevSecOps solutions...
1 week ago
Staff Forward Deployed Engineer - Applied AI (Remote)
$125K - $150K *
Innovate with us to transform manual workflows into efficient AI-driven solutions. As a Staff Forward Deployed Engineer, you'll collaborate closely with teams to streamline processes, enhancing produc...
2 weeks ago
Functional Lead, AI & Agentforce Delivery
$120K - $145K *
Lead the charge in delivering innovative AI and Agentforce solutions, managing implementation projects with a focus on customer success. Collaborate with teams to ensure strategic planning and executi...
2 weeks ago
$95K - $115K *
Transform the ScriptMed Cloud Platform by designing and deploying scalable solutions. Collaborate with teams to automate workflows and enhance customer onboarding while ensuring compliance with data s...
5 days ago
Senior Software Engineer, AI Platform Integration
$135K - $160K *
Join a team that's driving innovation in AI integration across diverse products. As a Senior Software Engineer, you'll enhance capabilities, collaborate with cross-functional teams, and ensure secure...
3 weeks ago
Customer Growth & Success Director - Cancer Registry
$135K - $165K *
Drive customer success in Cancer Registry by building relationships, enhancing retention, and translating insights into actionable solutions. Collaborate across teams to improve outcomes and shape bus...
5 days ago
$110K - $130K *
Elevate your career by architecting a cutting-edge digital growth engine. Drive enterprise lead generation through innovative strategies, leveraging AI and data analytics to optimize performance and m...
2 weeks ago
Senior Technical Success Manager, Emerging Enterprise - East
$120K - $145K *
Accelerate progress at customer deployments and adoption, driving value realization across a portfolio of accounts. Leverage technical fluency and business acumen to ensure successful outcomes and dee...
Today
$160K - $200K *
Champion the development of policy strategies that guide product decisions, ensuring compliance and safety while navigating complex regulatory landscapes. Collaborate with cross-functional teams to tr...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.