Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Software Engineer, Investment Technology Team
$110K - $130K *
Unlock your potential by driving software innovation in investment technology. Collaborate with cross-functional teams to deliver cutting-edge applications that enhance risk management and investment...
Reposted 2 weeks ago
$160K - $185K *
Lead the charge in designing Azure platforms for healthcare data products, ensuring resilience, security, and cost management while mentoring engineers and shaping architectural standards in a fully r...
1 week ago
Staff Engineer, Detection and Response
$225K - $281K *
Lead the charge in shaping detection and response strategies, driving hands-on initiatives to enhance security architecture and incident management. Collaborate across teams to ensure robust threat de...
2 weeks ago
$215K - $355K *
Transform AI solution delivery in Wealth Management by shaping and prototyping innovative solutions, collaborating with cross-functional teams, and driving adoption through stakeholder engagement and...
Reposted today
$95K - $115K *
Transform data governance by leveraging your technical expertise in Collibra and data quality tools. Drive accuracy and reliability of data assets through hands-on implementation and analysis, ensurin...
3 days ago
$100K - $120K *
Engage in innovative engineering solutions by leading design teams, ensuring structural integrity, and enhancing customer relationships while driving continuous improvement and profitability in a coll...
3 weeks ago
Talent Community Senior Application Engineer
$110K - $130K *
Join a dynamic team to create and implement control systems, providing technical support and mentoring while driving project success and ensuring optimal performance of HVAC and automation solutions...
Reposted 2 weeks ago
$128K - $165K *
Lead reliability initiatives across complex systems, driving automation and observability. Collaborate with teams to enhance operational outcomes, manage incidents, and mentor engineers, ensuring comp...
3 weeks ago
Senior Site Reliability Engineer II
$120K - $145K *
Drive system reliability and scalability as a Senior Site Reliability Engineer, focusing on automation and collaboration with software teams to enhance performance and maintain service objectives acro...
2 weeks ago
$138K - $163K *
Drive the evolution of software solutions for healthcare quality reporting, leading engineering teams to deliver innovative, high-quality products while fostering a culture of collaboration and contin...
Reposted today
Senior/Staff Full Stack Software Engineer
$180K - $240K *
Build innovative software solutions for federal partners, focusing on full-stack development, user experience, and secure integrations. Collaborate with cross-functional teams to deliver impactful app...
4 days ago
$80K - $95K *
Join a team that's dedicated to optimizing privacy management processes and compliance technology. This role supports platform administration, user engagement, and operational improvements, ensuring e...
3 weeks ago
$70K - $110K *
Elevate customer solutions by developing advanced analytics and machine learning systems. Collaborate with clients to address business challenges, implement best practices, and stay ahead of technolog...
Today
$110K - $130K *
Join a team that's redefining application security by guiding customers through complex evaluations. Leverage your expertise in offensive security to build relationships, deliver impactful demos, and...
1 week ago
$80K - $95K *
Shape global sourcing strategies and enhance procurement processes through data analytics, supplier performance management, and strategic initiatives. Collaborate across teams to drive savings and ens...
2 days ago
Senior System Software Engineer - Dynamo-Triton Inference Server
$224K - $356K *
Transform AI inference by leading the development of advanced GPU-accelerated software, driving feature innovation, and enhancing customer adoption in a collaborative open-source environment...
Reposted today
Alliance Marketing Manager, Artificial Intelligence
$126K - $273K *
Shape the future of alliance marketing by architecting innovative demand strategies with strategic tech partners, driving growth and impactful campaigns on a global scale, while collaborating across t...
Reposted 5 days ago
$125K - $145K *
Lead campaign strategy and execution for oncology pharma marketing, driving performance optimization and cross-functional collaboration. Own end-to-end campaign management, ensuring alignment with bus...
Reposted 1 week ago
$80K - $95K *
Take ownership of client relationships and campaign performance, managing a portfolio of accounts. Lead strategy discussions, optimize Meta campaigns, and ensure client satisfaction through proactive...
6 days ago
$80K - $95K *
Champion quality and compliance as you lead critical testing activities, ensuring adherence to standards while collaborating with teams to enhance product performance and customer satisfaction in a dy...
Reposted 1 week ago
$80K - $110K *
Join a team that's dedicated to enhancing software quality through innovative testing strategies. Collaborate with cross-functional teams to ensure reliable applications that support clinical research...
Yesterday
$110K - $120K *
Lead the charge in quality engineering for critical assessment platforms, driving testing excellence and automation maturity. Collaborate with cross-functional teams to ensure reliability and scalabil...
Reposted 3 days ago
$130K - $154K *
Lead full-lifecycle recruiting efforts, partnering with hiring managers to build strong candidate pipelines and improve processes across diverse talent markets. Drive data-driven insights to enhance h...
2 weeks ago
$126K - $137K *
Engineer and enhance DevOps practices while managing network infrastructure, automating software delivery, and ensuring security and reliability across environments to improve operational efficiency a...
3 weeks ago
$120K - $145K *
Empower your software engineering career by directing AI to deliver full-stack solutions. You'll manage end-to-end feature development, leveraging AWS and AI tools to enhance productivity and quality...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.