Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$120K - $145K *

Lead the charge in developing innovative AI software solutions, enhancing system performance, and collaborating with teams to align with IT roadmaps. Drive improvements through analysis and ensure sea...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$133K - $143K *

Elevate your career by developing AI algorithms and applications that drive data analysis and automation. Collaborate on innovative projects integrating Google Cloud LLMs with BigQuery to deliver acti...

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $115K *

Analyze and enhance client data reporting, driving insights and trends to support customer satisfaction and business growth. Collaborate with cross-functional teams to ensure data integrity and delive...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Drive AI transformation by mapping current processes and designing future-state models across G&A functions. Collaborate with stakeholders to identify automation opportunities and enhance operational...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$165K - $175K *

Unlock potential by leading enterprise data engineering initiatives, driving platform modernization, and enhancing operational excellence. Collaborate with cross-functional teams to deliver scalable...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Healthcare

$190K - $267K *

Lead data-driven strategies to enhance product development and user growth. Collaborate across teams to implement sophisticated analyses and metrics that drive business decisions and mentor junior tea...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Media

$100K - $185K *

Reimagine legal workflows as an AI Solutions Architect, driving AI adoption in law firms. Collaborate with teams to design and implement innovative solutions, enhancing efficiency and client advocacy...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$113K - $188K *

Lead the charge in building robust data platforms that transform complex datasets into actionable insights. This senior role demands expertise in software and data engineering, with a focus on quality...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$230K - $360K *

Elevate customer success by designing and deploying innovative Gen AI and ML solutions. Collaborate with stakeholders to translate complex needs into impactful AI tools, ensuring reliability and busin...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $110K *

Drive innovative data solutions by managing ETL processes and preparing AI datasets. Collaborate in a fast-paced Agile environment to translate complex requirements into efficient data strategies, ens...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$138K - $185K *

Transform your career by leading enterprise data and AI architecture initiatives. Collaborate with cross-functional teams to drive technology adoption and ensure alignment with business needs while in...

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$152K - $283K *

Accelerate analytics governance and operations by leading initiatives that enhance decision-making processes, streamline reporting, and modernize workflows across teams, ensuring effective collaborati...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$123K - $254K *

Architect innovative full-stack solutions that enhance user experiences, collaborating with cross-functional teams to drive product development from ideation to release, while ensuring high-quality co...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$172K - $202K *

Lead the charge in delivering impactful research and insights in analytics and AI. Collaborate with clients to identify needs, drive strategies, and produce high-quality content that shapes market tre...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Business Services

$120K - $140K *

Unlock potential by designing and deploying cutting-edge AI solutions that enhance enterprise operations. Collaborate across teams to create scalable, secure applications that drive efficiency and inn...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$152K - $259K *

Drive impactful product decisions by leading a high-performing Data Science team. Set strategic goals, prioritize initiatives, and foster a culture of accountability while collaborating with Product a...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Elevate your career by leading a dynamic team in data engineering and AI-ready data enablement. Drive innovation, mentor talent, and collaborate with IT and business teams to create trusted data produ...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $190K *

Create robust ML infrastructure to deploy, monitor, and maintain models, ensuring seamless integration between data science and engineering. Drive innovation in freight pricing, demand forecasting, an...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Transportation

$185K - $344K *

Lead a dynamic team in developing cutting-edge machine learning infrastructure, driving AI initiatives that impact millions. Foster collaboration and continuous improvement while mentoring talent in a...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$110K - $130K *

Pioneer the future of field service management by configuring and optimizing utility operations. Collaborate with teams to ensure seamless integration of AI-driven scheduling, enhancing efficiency and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$125K - $150K *

Shape the future of financial modeling by building and testing deep learning methods. Collaborate with a skilled team to transform innovative ideas into impactful solutions that enhance credit decisio...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$225K - $418K *

Elevate your career by leading advanced analytics initiatives that drive strategic business decisions and measurable impact. Collaborate with global teams to innovate and implement cutting-edge analyt...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive the future of engineering workflows by building and delivering robust AI-driven automation and agent-based capabilities, ensuring products meet real customer needs and are reliable for complex e...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$282K - $353K *

Transform the AI landscape by owning technical wins in enterprise deals, leveraging data architecture, and delivering superior AI solutions. Collaborate with executive teams to validate and design inn...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Transform data into actionable insights by building models that optimize carrier selection for auto insurance shoppers. Own media buying models to enhance ROAS, ensuring effective deployment and monit...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.