Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$120K - $145K *
Lead the charge in developing innovative AI software solutions, enhancing system performance, and collaborating with teams to align with IT roadmaps. Drive improvements through analysis and ensure sea...
Today
$133K - $143K *
Elevate your career by developing AI algorithms and applications that drive data analysis and automation. Collaborate on innovative projects integrating Google Cloud LLMs with BigQuery to deliver acti...
4 days ago
Data Analyst (Healthcare Data Analytics)
$80K - $115K *
Analyze and enhance client data reporting, driving insights and trends to support customer satisfaction and business growth. Collaborate with cross-functional teams to ensure data integrity and delive...
3 weeks ago
Senior AI Transformation Analyst
$90K - $110K *
Drive AI transformation by mapping current processes and designing future-state models across G&A functions. Collaborate with stakeholders to identify automation opportunities and enhance operational...
Reposted today
$165K - $175K *
Unlock potential by leading enterprise data engineering initiatives, driving platform modernization, and enhancing operational excellence. Collaborate with cross-functional teams to deliver scalable...
Reposted 1 week ago
Senior Data Scientist - Consumer
$190K - $267K *
Lead data-driven strategies to enhance product development and user growth. Collaborate across teams to implement sophisticated analyses and metrics that drive business decisions and mentor junior tea...
Reposted 6 days ago
$100K - $185K *
Reimagine legal workflows as an AI Solutions Architect, driving AI adoption in law firms. Collaborate with teams to design and implement innovative solutions, enhancing efficiency and client advocacy...
2 weeks ago
Senior Data Engineer (Analytics & Applied AI)
$113K - $188K *
Lead the charge in building robust data platforms that transform complex datasets into actionable insights. This senior role demands expertise in software and data engineering, with a focus on quality...
1 week ago
Staff Applied AI Engineer - Enterprise AI Solutions
$230K - $360K *
Elevate customer success by designing and deploying innovative Gen AI and ML solutions. Collaborate with stakeholders to translate complex needs into impactful AI tools, ensuring reliability and busin...
4 weeks ago
$90K - $110K *
Drive innovative data solutions by managing ETL processes and preparing AI datasets. Collaborate in a fast-paced Agile environment to translate complex requirements into efficient data strategies, ens...
1 week ago
Expert Architect - Enterprise Data AI Platforms
$138K - $185K *
Transform your career by leading enterprise data and AI architecture initiatives. Collaborate with cross-functional teams to drive technology adoption and ensure alignment with business needs while in...
1 week ago
Associate Director, Analytics Governance & Operations
$152K - $283K *
Accelerate analytics governance and operations by leading initiatives that enhance decision-making processes, streamline reporting, and modernize workflows across teams, ensuring effective collaborati...
1 week ago
Software Engineer II, Monetization Engineering
$123K - $254K *
Architect innovative full-stack solutions that enhance user experiences, collaborating with cross-functional teams to drive product development from ideation to release, while ensuring high-quality co...
4 weeks ago
Sr Director Analyst- Analytics & AI
$172K - $202K *
Lead the charge in delivering impactful research and insights in analytics and AI. Collaborate with clients to identify needs, drive strategies, and produce high-quality content that shapes market tre...
3 weeks ago
$120K - $140K *
Unlock potential by designing and deploying cutting-edge AI solutions that enhance enterprise operations. Collaborate across teams to create scalable, secure applications that drive efficiency and inn...
2 weeks ago
$152K - $259K *
Drive impactful product decisions by leading a high-performing Data Science team. Set strategic goals, prioritize initiatives, and foster a culture of accountability while collaborating with Product a...
4 days ago
Manager, Data Engineering and AI-Ready Data Enablement
$120K - $145K *
Elevate your career by leading a dynamic team in data engineering and AI-ready data enablement. Drive innovation, mentor talent, and collaborate with IT and business teams to create trusted data produ...
1 week ago
Senior Machine Learning Engineer (MLOps)
$140K - $190K *
Create robust ML infrastructure to deploy, monitor, and maintain models, ensuring seamless integration between data science and engineering. Drive innovation in freight pricing, demand forecasting, an...
Yesterday
Manager Machine Learning Engineering
$185K - $344K *
Lead a dynamic team in developing cutting-edge machine learning infrastructure, driving AI initiatives that impact millions. Foster collaboration and continuous improvement while mentoring talent in a...
Reposted 3 days ago
Implementation Consultant - Service
$110K - $130K *
Pioneer the future of field service management by configuring and optimizing utility operations. Collaborate with teams to ensure seamless integration of AI-driven scheduling, enhancing efficiency and...
2 weeks ago
Senior Data Scientist, Methodologies
$125K - $150K *
Shape the future of financial modeling by building and testing deep learning methods. Collaborate with a skilled team to transform innovative ideas into impactful solutions that enhance credit decisio...
5 days ago
ED, Advanced Analytics and Modeling
$225K - $418K *
Elevate your career by leading advanced analytics initiatives that drive strategic business decisions and measurable impact. Collaborate with global teams to innovate and implement cutting-edge analyt...
4 days ago
Applications Engineers, Agentic Workflows
$110K - $130K *
Drive the future of engineering workflows by building and delivering robust AI-driven automation and agent-based capabilities, ensuring products meet real customer needs and are reliable for complex e...
Reposted today
$282K - $353K *
Transform the AI landscape by owning technical wins in enterprise deals, leveraging data architecture, and delivering superior AI solutions. Collaborate with executive teams to validate and design inn...
Reposted 5 days ago
$120K - $145K *
Transform data into actionable insights by building models that optimize carrier selection for auto insurance shoppers. Own media buying models to enhance ROAS, ensuring effective deployment and monit...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.