Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Director, Client Advisory and Insights
$150K *
Shape the future of client success by leveraging insights and data to enhance program impact. Collaborate with leaders in law firms and professional services to drive engagement and talent development...
Reposted 2 days ago
Senior Financial Systems Analyst
$106K - $127K *
Empower finance teams by bridging systems and analysis, enhancing budgeting, forecasting, and reporting processes. Collaborate with stakeholders to translate needs into effective solutions, driving im...
3 days ago
Senior/Staff Credit Data Scientist
$143K - $220K *
Unlock the potential of credit analytics by developing predictive models and optimizing strategies. Collaborate across teams to drive data-informed decisions that enhance lending growth and improve ri...
Yesterday
Senior Product Manager, Deceptive Content
$164K - $339K *
Drive the product strategy for GenAI safety, ensuring AI systems are safe, fair, and trustworthy. Collaborate with cross-functional teams to identify risks and translate policies into product requirem...
Reposted 2 weeks ago
Group Project Manager, Healthcare and Pharmaceutical Advertising
$120K - $150K *
Lead complex project management initiatives across multiple channels in the pharmaceutical advertising sector. Oversee cross-functional teams, ensuring timely delivery within budget while mentoring ju...
1 week ago
$80K - $95K *
Join a team that's dedicated to designing impactful airport engineering projects. Collaborate on construction plans and technical specifications while enhancing your skills in a fast-paced environment...
2 weeks ago
$110K - $130K *
Transform financial operations by leveraging Workday expertise to enhance reporting, payroll, and planning processes. Collaborate with cross-functional teams to deliver scalable solutions and drive co...
Reposted 3 weeks ago
Lead Bioinformatics Scientist (Oncology)
$130K - $163K *
Champion the analytical validation of NGS assays, driving real-world evidence studies and collaborating with cross-functional teams to enhance oncology applications and support regulatory submissions...
5 days ago
$80K - $95K *
Engage deeply with customers to drive innovative solutions in motion control and robotics. Support deployment, optimize performance, and ensure reliable operation in diverse applications while contrib...
Reposted 4 days ago
Senior Cost Manager - Data Center
$130K - $155K *
Lead the charge in delivering high-quality cost management services for large-scale data center projects. Collaborate with clients and stakeholders to ensure project objectives are met throughout the...
Today
Managing Director, Assessment & Human Capital
$170K - $230K *
Drive strategic growth and innovation in AI-enabled assessment and workforce solutions. Lead high-impact projects, foster collaboration, and enhance AIR's national leadership in education and workforc...
6 days ago
$132K - $155K *
Unlock potential by providing advanced technical support and solutions, ensuring exceptional customer experiences. Collaborate with teams to resolve issues, mentor peers, and drive product improvement...
5 days ago
Sr. Network Operations Analyst
$110K - $130K *
Elevate network operations by leading complex incident responses and mentoring teams. Collaborate with cross-functional partners to enhance network reliability and operational maturity across global e...
2 weeks ago
$110K - $130K *
Join our team to drive revenue growth by winning new business and establishing strategic relationships with key accounts. Collaborate with senior management to develop effective strategies and ensure...
3 weeks ago
Bioanalytical Technical Proposal Manager
$100K - $120K *
Shape the future of technical proposals by collaborating with cross-functional teams to create compelling, scientifically accurate documents that meet client needs and drive business success in the li...
1 week ago
$108K - $130K *
Innovate the go-to-market systems by building AI agents and infrastructure that drive pipeline efficiency, ensuring seamless integration and reliability across sales and marketing operations...
4 days ago
Strategic Project Lead - Finance
$100K - $120K *
Elevate your career by leading strategic finance pilots to drive AI model training and evaluation. This hands-on role combines financial expertise and operational leadership to transform emerging proj...
Reposted today
Senior Director, Talent Acquisition
$190K - $280K *
Transform talent acquisition by leading a global team to enhance recruiting efficiency, drive strategy, and leverage AI for measurable improvements across diverse markets while ensuring compliance and...
Reposted today
Senior Analyst, Business Operations & Strategy
$111K - $167K *
Optimize the customer journey by leveraging analytics and strategic insights to enhance pipeline generation, forecasting, and sales enablement for a growing Property Care business. Collaborate cross-f...
Yesterday
$120K - $140K *
Shape the future of cooling technology by developing cost models for large-scale systems. Collaborate with leadership and engineering to optimize pricing strategies, enhance margins, and drive growth...
2 weeks ago
$95K - $115K *
Elevate your career by building and maintaining CI/CD pipelines, administering servers, and leading DevOps initiatives. Collaborate with teams to enhance application performance and security while men...
4 days ago
Senior Account Executive - Utilities / Distribution / Data Centers
$110K - $130K *
Help us advance our utilities and data center solutions by leading strategic customer partnerships, identifying market needs, and fostering scalable growth for a trusted workforce collaboration in cri...
Reposted 2 weeks ago
Senior Software Engineer - Growth
$120K - $145K *
Lead the charge in transforming patient engagement by integrating booking into our core product. Drive innovative experiments and optimize multi-channel outreach to ensure underserved communities rece...
5 days ago
Principal Consultant - Senior SAP Sales Executive
$150K - $180K *
Transform the SAP sales landscape by leveraging your extensive network and expertise to drive new business acquisition in the manufacturing sector. Own the full sales cycle, from lead generation to cl...
5 days ago
$108K - $130K *
Drive the end-to-end release process for enterprise software, ensuring predictable, compliant, and low-risk deployments. Collaborate with cross-functional teams to manage risks, approvals, and communi...
4 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.