Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$150K - $180K *
Lead the charge in enhancing engineering security for our SaaS platform. Collaborate with teams to identify risks, improve practices, and implement automation, ensuring secure development and robust v...
5 days ago
$150K - $180K *
Join a team that's shaping the future of AI by designing and implementing enterprise-grade solutions on Google Cloud and Azure, focusing on data migration, pipeline development, and robust cloud infra...
1 week ago
Security Operations Analyst - West Coast Shift
$100K - $125K *
Optimize security operations by triaging and investigating alerts, mitigating cyber threats effectively. Join a dedicated team to enhance your analyst skills while actively protecting organizations fr...
Reposted 2 weeks ago
$110K - $130K *
Lead feasibility strategy and execution for clinical studies, driving operational excellence and data-driven insights to optimize trial planning and enrollment across rare disease programs. Collaborat...
1 week ago
Principal Cloud Engineer - AI Platform
$175K - $250K *
Shape the cloud infrastructure for AI agents, ensuring secure, scalable solutions that enhance customer workflows. Lead architectural decisions, establish standards, and drive innovation in a dynamic...
Reposted 3 days ago
$95K - $115K *
Elevate your career by contributing to critical security initiatives, leveraging your expertise in incident response, cryptographic modernization, and technical policy formulation to enhance enterpris...
1 week ago
ERP Functional Business Analyst - Performance Budgeting (PB)
$89K - $156K *
Transform enterprise budgeting solutions by analyzing processes, defining requirements, and configuring applications. Collaborate with stakeholders to enhance financial planning and ensure successful...
Reposted 3 weeks ago
$90K - $100K *
Join a team that's dedicated to optimizing payroll operations and compliance. This role supports payroll processing, reporting, and employee services, ensuring accuracy and scalability as the organiza...
5 days ago
Strategy & Ops Lead, Applied AI
$110K - $130K *
Optimize internal tooling ecosystems to enhance operational efficiency. Collaborate with engineering to develop AI-driven solutions and automate workflows that streamline team processes and enable sca...
Reposted 3 weeks ago
$110K - $130K *
Join a team that's shaping regulatory compliance in the aerospace sector. You'll lead initiatives across export controls, satellite regulations, and corporate compliance, ensuring our operations meet...
5 days ago
Epic Clinical Sr. Reporting Business Analyst
$95K - $115K *
Unlock potential by leading analytics initiatives, transforming data into actionable insights, and mentoring junior analysts. Collaborate with stakeholders to enhance reporting solutions and drive ope...
3 weeks ago
Market Research & Analytics Senior Manager
$162K - $203K *
Drive impactful market research initiatives by collaborating with cross-functional teams to translate business needs into actionable insights, ensuring high-quality execution and strategic decision-ma...
Today
$75K - $105K *
Collaborate with clients to enhance their social media strategies using healthcare insights, data-driven execution, and creative content development for multi-channel success. This role demands a proa...
Reposted 2 weeks ago
$104K - $130K *
Empower your career by designing, deploying, and optimizing cutting-edge AI & ML infrastructures in dynamic client environments. Collaborate with cross-functional teams to drive innovation and excelle...
Reposted 2 weeks ago
Director, HR Business Partner - Corporate Functions
$119K - $190K *
Shape the future of our Corporate Functions by partnering with senior leaders to drive talent strategy, organizational effectiveness, and leadership development. Leverage data and insights to influenc...
5 days ago
$128K - $214K *
Help us shape the future of data science by developing advanced analytics and machine learning solutions for federal clients. Collaborate with a dynamic team to drive impactful data-driven decisions a...
3 weeks ago
Sales Manager - Australia/New Zealand Market
$100K - $120K *
Accelerate sales growth by leading strategies and initiatives across the ANZ market. Collaborate with a multidisciplinary team to drive customer engagement, develop market strategies, and achieve reve...
Reposted 5 days ago
Customer Success Manager (AI Success Architect)
$116K - $148K *
Transform enterprise operations by guiding customers in AI adoption and maximizing Asana's capabilities. Own post-sales relationships, ensuring measurable outcomes and strategic success across a portf...
Today
Technical Product Owner – Data Products
$110K - $130K *
Join a dynamic team to bridge product strategy and engineering delivery, transforming data into actionable insights for innovative financial solutions. Collaborate with cross-functional teams to drive...
Reposted 1 week ago
$95K - $115K *
Lead the charge in advanced financial analysis and strategic sourcing initiatives, collaborating with cross-functional teams to drive insights and influence decision-making across multiple divisions a...
1 week ago
Director of Provider Analytics
$138K - $201K *
Transform provider analytics by leading data-driven insights for contracting, performance, and network strategy. Collaborate with cross-functional teams to enhance network adequacy and drive strategic...
4 weeks ago
Director Continuous Improvement
$120K - $150K *
Champion continuous improvement initiatives by optimizing processes and products across the organization. Lead cross-functional teams to enhance operational efficiency, quality, and customer experienc...
3 weeks ago
$131K - $209K *
Engage with teams to deliver comprehensive AI enablement programs, designing tailored learning paths and fostering a culture of proficiency across all departments. Collaborate closely with HR to integ...
Reposted today
Senior/Staff Attack Engineer, Rapid Response
$230K - $275K *
Lead the charge in vulnerability research and exploitation techniques, transforming real-world threats into automated solutions. Collaborate with teams to enhance security measures and validate defens...
3 weeks ago
Full-Stack Engineer - AI-Native Solutions
$98K - $163K *
Shape the future of enterprise software by building secure, scalable applications. Collaborate with cross-functional teams to integrate AI capabilities and deliver innovative solutions that meet busin...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.