Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Electrical Engineering Consultant 2 - Nuclear
$145K - $222K *
Lead and mentor a team in tackling complex electrical engineering projects, ensuring successful delivery and client satisfaction while coordinating multi-discipline efforts in the nuclear power sector...
3 weeks ago
Software Engineer II- Full-stack Developer
$95K - $188K *
Drive the development of innovative cloud-native applications and AI features as a full-stack developer. Collaborate with senior engineers to enhance your skills while delivering impactful solutions i...
3 days ago
Software Engineer II- Full-stack Developer
$95K - $188K *
Unlock your potential as a full-stack developer, contributing to cloud-native applications and AI features. Collaborate with senior engineers, enhance your skills, and deliver impactful software solut...
3 days ago
Senior Software Engineer, Python
$170K - $200K *
Advance backend solutions and frontend features, collaborating across teams to build scalable systems and AI integrations, driving product growth from conception to execution...
Reposted 1 week ago
Sr. Manager, Analyst Relations
$165K - $190K *
Advance your career by shaping analyst relations and market perception in AI and automation. Collaborate with cross-functional teams to drive impactful evaluations and strategic narratives that enhanc...
2 weeks ago
Engineering Manager, Governance & Access
$150K - $180K *
Empower our team to build innovative security and governance solutions, shaping access management for both human and agent users. Lead a small, dynamic group as we define architectural foundations and...
3 weeks ago
$120K - $145K *
Drive the design and development of innovative software solutions while mentoring junior engineers. Leverage extensive technical expertise to enhance system architecture and ensure high-quality delive...
1 week ago
Technical Content Developer Associate Manager, AI POD
$73K - $182K *
Create impactful AI learning experiences by developing courses, labs, and assessments. Collaborate with experts to ensure technical accuracy and instructional quality, enabling learners to apply AI sk...
Today
Product Manager, National Center for Clinical Trials (NCCT)
$122K - $183K *
Transform how we operate by leading technology-driven initiatives that enhance business capabilities. Collaborate with cross-functional teams to define product strategies and drive measurable outcomes...
4 days ago
$85K - $95K *
Engage in the development and execution of automated testing strategies, ensuring software quality through comprehensive test plans and scripts. Collaborate with teams to maintain CI/CD pipelines and...
5 days ago
$100K - $130K *
Drive credit risk assessments and limit approvals for institutional clients, enhancing reporting tools and compliance. Collaborate with teams to mitigate risks and improve efficiencies in a fast-paced...
4 weeks ago
$80K - $92K *
Drive the resolution of technical support escalations as a key Tier 2 expert, leveraging your skills to troubleshoot issues, foster collaboration within teams, and enhance workflows in a dynamic envir...
Reposted 4 days ago
Senior Software Engineer, Observability
$120K - $145K *
Champion the development of innovative observability solutions, leveraging your expertise in Go and network protocols to enhance network automation. Collaborate with cross-functional teams to deliver...
4 weeks ago
$120K - $145K *
Engage in technical leadership and project management to develop industry standards and reports. Collaborate with working groups to drive best practices and support continuous improvement initiatives...
1 week ago
Hospital Coding Quality Integrity Analyst - Inpatient
$73K - $110K *
Elevate your career by ensuring coding accuracy and compliance in a dynamic healthcare environment. Collaborate with teams to enhance documentation quality and drive improvements in coding practices w...
Reposted 2 days ago
Project Engineer - Industrial Automation
$140K *
Design innovative control systems and automation solutions, managing project scope, budget, and vendor relations. Collaborate with teams to ensure successful commissioning and provide ongoing technica...
3 weeks ago
$150K - $180K *
Lead high-impact executive searches across IT services, leveraging AI tools and a robust network to identify and engage top-tier talent. Drive outcomes by advising senior leaders and ensuring successf...
5 days ago
Senior Pricing Analyst - Material Cost Estimator
$79K - $103K *
Transform cost estimation processes by collaborating with multifaceted teams to deliver precise material pricing for DoD proposals, ensuring compliance and competitiveness while supporting strategic d...
Reposted 1 week ago
$350K *
Engage with key enterprise clients to drive revenue growth through strategic, solution-based sales. Develop lasting relationships and navigate complex sales processes while championing company values...
Reposted 2 days ago
$90K - $110K *
Shape customer success by designing tailored technical solutions and delivering impactful presentations. Collaborate with sales teams to leverage infrastructure, ensuring alignment with network capabi...
1 week ago
Senior Engineering Manager, AI Platform
$150K - $180K *
Lead and develop a high-performing Applied AI team, driving the delivery of production AI systems while ensuring security, reliability, and operational excellence in healthcare applications...
Today
Compensation Analyst (Americas)- Remote USA
$80K - $95K *
Unlock your potential as a Compensation Analyst, driving sales quota management and performance tracking. Collaborate with leadership to optimize compensation plans and enhance operational efficiency...
Yesterday
Business Insights Analyst, Remote US
$80K - $95K *
Grow your career with a dynamic role that drives actionable insights across e-commerce and service delivery. Collaborate with stakeholders to analyze data, build impactful reports, and enhance busines...
2 weeks ago
GIS Software Quality Assurance Engineer
$95K - $120K *
Elevate software quality assurance by testing GIS applications and validating complex datasets. Collaborate with developers and GIS specialists to ensure accuracy and reliability in geospatial data fo...
2 weeks ago
$86K - $144K *
Unlock potential by leading the design and development of scalable generative AI services, ensuring architectural integrity and mentoring teams. Collaborate with cross-functional stakeholders to drive...
Reposted 2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.