Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$180K - $200K *
Elevate healthcare technology by owning mobile and web apps that enhance clinician workflows. Drive product direction, prioritize initiatives, and ensure patient safety while leveraging AI to improve...
1 week ago
Engineering Manager - Member Experience
$179K - $224K *
Join a team that's dedicated to delivering high-quality member-facing systems. As an Engineering Manager, you'll lead a squad through the entire development lifecycle, ensuring accountability, quality...
3 weeks ago
Senior Risk Analyst, Payments Risk Operations
$180K - $212K *
Join a team that's redefining risk management in payments. As a Senior Risk Analyst, you'll tackle complex fraud cases, enhance workflows, and collaborate with cross-functional teams to drive impactfu...
Yesterday
Senior Software Engineer, Infrastructure Engineering
$190K - $267K *
Champion innovation by leading cross-functional teams to design and deliver scalable, high-performance infrastructure solutions that enhance reliability and efficiency across diverse applications and...
5 days ago
Software Engineer III - Full Stack (Drupal)
$105K - $110K *
Drive innovation as a Software Engineer III, enhancing full-stack capabilities and mentoring junior developers while collaborating with stakeholders to improve engineering processes and deliver impact...
Reposted 6 days ago
$88K - $105K *
Engage with us to advance hypersonic weapon systems as a Test Analyst, supporting critical testing operations. Collaborate with engineers and stakeholders to analyze data and develop test plans, ensur...
Today
Senior Manager, Program Dev/QC
$110K - $130K *
Elevate your career by managing diverse EV projects, ensuring successful delivery through collaboration, strategic planning, and effective stakeholder engagement. Drive project excellence while naviga...
3 weeks ago
$95K - $115K *
Champion security and operational resilience by enhancing controls, managing risks, and collaborating with stakeholders to implement effective cybersecurity solutions that support business productivit...
2 weeks ago
Senior Technical Talent Researcher
$100K - $120K *
Champion the recruitment of top technical talent by leveraging innovative sourcing techniques and building strong client relationships to enhance talent acquisition strategies and drive organizational...
3 weeks ago
$120K - $150K *
Elevate product innovation by leading cross-functional teams to develop AI tools and workflows. Drive project momentum through hands-on prototyping and clear communication, ensuring alignment between...
4 weeks ago
Advanced Software Engineer - AI Reliability Engineering
$118K - $131K *
Optimize your career by joining a dynamic team that develops cutting-edge AI-native solutions. Engage in full software development lifecycle, collaborating with users to create impactful technologies...
Yesterday
$193K - $228K *
Lead the charge in transforming enterprise architecture by aligning technology with business goals, driving innovation, and managing technical debt to enhance application ecosystems and ensure scalabi...
Today
$150K - $200K *
Unlock potential by driving AI strategy and innovation for customer success. Collaborate with stakeholders to optimize AI solutions, enhance operational efficiency, and deliver measurable business imp...
3 weeks ago
$120K - $140K *
Architect AI-driven solutions to enhance GTM operations, streamline workflows, and empower sales and support teams. Collaborate cross-functionally to automate processes, improve efficiency, and drive...
2 weeks ago
Senior Program Manager - Data Center Construction
$110K - $130K *
Take ownership of large-scale construction projects, managing stakeholders and ensuring compliance. Oversee project governance, track milestones, and enhance processes while fostering client relations...
Yesterday
$168K - $285K *
Shape the future of financial strategy by leading R&D finance, partnering with executives to drive investment decisions, optimize spending, and enhance forecasting accuracy in a dynamic, AI-driven env...
2 weeks ago
$63K - $129K *
Contribute to system quality by executing test cases, analyzing requirements, and validating functionality to ensure compliance and stability in a fast-paced environment. Collaborate with teams to enh...
Reposted 2 weeks ago
$230K - $260K *
Redefine global compensation and benefits strategies to attract AI talent, ensuring fairness and scalability across 18 countries while collaborating with executives and leveraging AI for innovative re...
2 weeks ago
Senior Director, Site Reliability Engineering
$175K - $250K *
Lead the charge in enhancing the reliability and scalability of a global multi-tenant platform. Drive SRE strategy, foster collaboration across teams, and ensure operational excellence while developin...
5 days ago
Cloud Platform and Data Engineer [U.S. Citizenship Required, Public Trust Eligibility]
$100K - $120K *
Unlock your potential as a Cloud Platform and Data Engineer, driving innovation in secure cloud environments. Collaborate with cross-functional teams to enhance Salesforce applications and AWS infrast...
5 days ago
$90K - $115K *
Join a dynamic team to lead client accounts, translating needs into effective strategies while fostering strong relationships and guiding junior members. Drive successful project execution and proacti...
4 days ago
$65K - $108K *
Unlock potential by providing advanced technical support and engineering expertise to resolve complex production issues. Manage end-to-end case ownership while collaborating with teams to enhance serv...
3 weeks ago
Engineer, Software Engineering
$112K - $140K *
Contribute to the development of innovative healthcare solutions by designing and maintaining backend services using Java and Spring Boot, while collaborating with a global team to enhance a scalable...
Yesterday
Marketing Cloud Next Solution Architect
$120K - $145K *
Transform client engagements by leading functional solution design for Salesforce Marketing Cloud Next, integrating marketing strategy with data architecture to optimize multi-channel campaigns and en...
2 weeks ago
Director, Data Science - Rollout acceleration AI
$150K - $180K *
Drive your career forward by leveraging advanced AI to enhance pricing programs. Join a new, dynamic team focused on building evaluations that ensure AI delivers value and accuracy, shaping the future...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.