Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$95K - $115K *
Accelerate progress at the intersection of marketing and data analytics. As a key player, you'll build reporting functions, define KPIs, and drive insights that empower teams across the organization t...
1 week ago
$110K - $130K *
Drive analytics initiatives that connect Paid Media performance to full-funnel outcomes. Collaborate with cross-functional teams to design measurement frameworks, optimize data models, and provide act...
Reposted 2 weeks ago
$110K - $130K *
Drive innovative solutions by leveraging data analytics and strategic counsel to enhance client performance. Collaborate with high-performing teams to deliver tailored insights for transformational ev...
2 weeks ago
Engineering Manager, Data Streaming
$225K - $265K *
Accelerate progress at a mission-critical team, leading Data Streaming to enhance data ingestion pipelines. Build a skilled team, ensure pipeline reliability, and collaborate cross-functionally to sup...
1 week ago
Insights Lead, Brand & Consumer Analytics
$122K - $292K *
Lead advanced analytics initiatives to transform data into actionable insights, driving strategic decisions across Brand and Consumer-focused projects. Collaborate with stakeholders to enhance busines...
Today
Data Analyst, Clinical Data Effectiveness
$95K - $115K *
Analyze and optimize the clinical data lifecycle, ensuring data completeness and integrity. Collaborate cross-functionally to enhance clinical data flows and vendor strategies, driving quality improve...
Reposted today
$172K - $205K *
Transform data into actionable insights to optimize the insurance business. Collaborate with cross-functional teams to enhance customer experience and drive revenue growth through advanced analytics a...
Today
Senior Applied Scientist II, Ads Optimization
$240K - $253K *
Pioneer innovation in real-time bid optimization systems, driving advertising performance by turning complex mathematical insights into robust production code. Lead cross-functional initiatives to max...
Reposted 4 days ago
Senior Data Scientist, Platform
$180K - $212K *
Elevate decision-making through data analysis and modeling. Collaborate with cross-functional teams to drive insights, enhance product performance, and influence strategic direction using advanced ana...
Yesterday
Senior Machine Learning Engineer, ML Infrastructure- Online
$210K - $273K *
Drive the evolution of a robust online ML inference platform, enhancing model deployment, performance, and safety in high-traffic environments by collaborating with cross-functional teams and spearhea...
Reposted 3 days ago
Cyber Data Analyst Engineer III
$101K - $111K *
Contribute to the design and maintenance of automated infrastructure, leveraging Kubernetes and Ansible. Engage with customers to enhance server lifecycle processes and ensure optimal CI/CD performanc...
3 weeks ago
Staff Machine Learning Engineer, Retrieval & Targeting
$230K - $322K *
Grow your career with a leading ML team focused on enhancing ad retrieval systems. Drive technical direction, develop innovative models, and collaborate across teams to optimize user experience and ad...
1 week ago
AI Deployment Engineer/Manager
$80K - $95K *
Champion the deployment of cutting-edge AI systems in diverse environments. Collaborate with teams to ensure seamless installation and operation of hardware and software, while providing exceptional c...
1 week ago
$150K - $190K *
Unlock potential by designing scalable data models and ensuring data quality. Collaborate with cross-functional teams to translate business needs into technical solutions, driving analytics excellence...
1 week ago
Senior Data Scientist II, Monetization
$183K - $216K *
Take ownership of the scientific and product roadmap for monetization, leading audience creation and measurement methodologies. Collaborate with cross-functional teams to drive product strategy and in...
2 weeks ago
Lead Consultant, AI & Analytics
$120K - $145K *
Drive the future of AI & Analytics by leading client relationships, providing strategic guidance, and delivering innovative solutions. Leverage your expertise to enhance service delivery and ensure al...
1 week ago
Sr. Data Scientist, Forward-Deployed
$168K - $230K *
Lead impactful data science initiatives by measuring engagement outcomes and building customer models. Collaborate with senior data scientists to drive analytics that directly influence business succe...
Reposted today
Senior Data Scientist II, Core & Agentic Automation
$183K - $216K *
Unlock your potential by leading data science initiatives that drive impactful decision-making and enhance analytical frameworks across teams, ensuring rigorous performance standards and scalable self...
1 week ago
Lead Forward-Deployed AI Engineer
$135K - $160K *
Lead the charge in delivering hands-on technical solutions for pharma clients, coordinating with teams to ensure successful project execution and measurable business impact while fostering collaborati...
Today
$120K - $145K *
Join a team that's pioneering the deployment of scalable AI systems, focusing on building robust APIs, optimizing infrastructure, and ensuring reliable operations in a dynamic environment. Drive innov...
1 week ago
Senior Machine Learning Systems Engineer - Search
$150K - $180K *
Join a team that's at the forefront of machine learning and search innovation. Collaborate with cross-functional teams to develop scalable ML systems that enhance user experiences and drive impactful...
3 weeks ago
Senior Analyst, Data Analytics
$76K - $125K *
Join a team that's dedicated to delivering accurate sales reporting and data maintenance. This role supports sales leaders and partners by managing reporting queues, ensuring data integrity, and enhan...
4 weeks ago
Principal Data Analyst, Clinical Analytics and Reporting
$78K - $119K *
Drive advanced analytical support for clinical initiatives, leading data strategy and delivering insights to inform clinical programs. Collaborate with executives to enhance decision-making and mentor...
Today
$130K - $155K *
Champion innovative data solutions by designing and maintaining robust data pipelines across Azure and Microsoft Fabric, ensuring high-quality data delivery and governance while leading engineering in...
Yesterday
$130K - $155K *
Join a team that's redefining data infrastructure by owning and optimizing our data pipelines, warehouse, and modeling layers. Collaborate with cross-functional teams to ensure data integrity and driv...
Reposted 2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.