Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$95K - $115K *

Accelerate progress at the intersection of marketing and data analytics. As a key player, you'll build reporting functions, define KPIs, and drive insights that empower teams across the organization t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Drive analytics initiatives that connect Paid Media performance to full-funnel outcomes. Collaborate with cross-functional teams to design measurement frameworks, optimize data models, and provide act...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Drive innovative solutions by leveraging data analytics and strategic counsel to enhance client performance. Collaborate with high-performing teams to deliver tailored insights for transformational ev...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$225K - $265K *

Accelerate progress at a mission-critical team, leading Data Streaming to enhance data ingestion pipelines. Build a skilled team, ensure pipeline reliability, and collaborate cross-functionally to sup...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$122K - $292K *

Lead advanced analytics initiatives to transform data into actionable insights, driving strategic decisions across Brand and Consumer-focused projects. Collaborate with stakeholders to enhance busines...

Today

  •   8 - 10 years exp.  •   Business Services

$95K - $115K *

Analyze and optimize the clinical data lifecycle, ensuring data completeness and integrity. Collaborate cross-functionally to enhance clinical data flows and vendor strategies, driving quality improve...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$172K - $205K *

Transform data into actionable insights to optimize the insurance business. Collaborate with cross-functional teams to enhance customer experience and drive revenue growth through advanced analytics a...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$240K - $253K *

Pioneer innovation in real-time bid optimization systems, driving advertising performance by turning complex mathematical insights into robust production code. Lead cross-functional initiatives to max...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$180K - $212K *

Elevate decision-making through data analysis and modeling. Collaborate with cross-functional teams to drive insights, enhance product performance, and influence strategic direction using advanced ana...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$210K - $273K *

Drive the evolution of a robust online ML inference platform, enhancing model deployment, performance, and safety in high-traffic environments by collaborating with cross-functional teams and spearhea...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$101K - $111K *

Contribute to the design and maintenance of automated infrastructure, leveraging Kubernetes and Ansible. Engage with customers to enhance server lifecycle processes and ensure optimal CI/CD performanc...

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$230K - $322K *

Grow your career with a leading ML team focused on enhancing ad retrieval systems. Drive technical direction, develop innovative models, and collaborate across teams to optimize user experience and ad...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$80K - $95K *

Champion the deployment of cutting-edge AI systems in diverse environments. Collaborate with teams to ensure seamless installation and operation of hardware and software, while providing exceptional c...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $190K *

Unlock potential by designing scalable data models and ensuring data quality. Collaborate with cross-functional teams to translate business needs into technical solutions, driving analytics excellence...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$183K - $216K *

Take ownership of the scientific and product roadmap for monetization, leading audience creation and measurement methodologies. Collaborate with cross-functional teams to drive product strategy and in...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$120K - $145K *

Drive the future of AI & Analytics by leading client relationships, providing strategic guidance, and delivering innovative solutions. Leverage your expertise to enhance service delivery and ensure al...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$168K - $230K *

Lead impactful data science initiatives by measuring engagement outcomes and building customer models. Collaborate with senior data scientists to drive analytics that directly influence business succe...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$183K - $216K *

Unlock your potential by leading data science initiatives that drive impactful decision-making and enhance analytical frameworks across teams, ensuring rigorous performance standards and scalable self...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$135K - $160K *

Lead the charge in delivering hands-on technical solutions for pharma clients, coordinating with teams to ensure successful project execution and measurable business impact while fostering collaborati...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Join a team that's pioneering the deployment of scalable AI systems, focusing on building robust APIs, optimizing infrastructure, and ensuring reliable operations in a dynamic environment. Drive innov...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Join a team that's at the forefront of machine learning and search innovation. Collaborate with cross-functional teams to develop scalable ML systems that enhance user experiences and drive impactful...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$76K - $125K *

Join a team that's dedicated to delivering accurate sales reporting and data maintenance. This role supports sales leaders and partners by managing reporting queues, ensuring data integrity, and enhan...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$78K - $119K *

Drive advanced analytical support for clinical initiatives, leading data strategy and delivering insights to inform clinical programs. Collaborate with executives to enhance decision-making and mentor...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$130K - $155K *

Champion innovative data solutions by designing and maintaining robust data pipelines across Azure and Microsoft Fabric, ensuring high-quality data delivery and governance while leading engineering in...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$130K - $155K *

Join a team that's redefining data infrastructure by owning and optimizing our data pipelines, warehouse, and modeling layers. Collaborate with cross-functional teams to ensure data integrity and driv...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.