Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
AI Administrator, Business Applications
$115K - $151K *
Grow your career with a dynamic team focused on AI tool administration and governance. Collaborate across departments to enhance system connectivity and process automation while ensuring data privacy...
Reposted today
Senior Engineering Manager, Grafana Frontend | USA | Remote
$208K - $250K *
Shape the future of Grafana by leading frontend development squads, fostering collaboration and innovation to enhance user experiences. Drive AI integration and team growth while managing strategic pr...
Reposted 2 weeks ago
Senior Marketing Manager, Frontier AI
$138K - $165K *
Accelerate progress at the forefront of AI by leading innovative marketing strategies. Leverage your expertise to shape and expand market presence while collaborating with top researchers and organiza...
Reposted 4 weeks ago
$100K - $120K *
Transform internal operations by leveraging AI to streamline workflows, enhance reporting, and drive efficiency across Finance, People, and Legal teams. Collaborate with stakeholders to identify high...
4 days ago
$160K - $200K *
Transform customer success and support by leading a dynamic team to enhance retention and expansion strategies. Collaborate with executives to build infrastructure and drive growth for 2,100+ accounts...
4 weeks ago
Senior Software Engineer II, Mobile - Revenue Experimentation (AI Native)
$118K - $216K *
Innovate and drive growth by designing and executing high-velocity monetization experiments. Collaborate with cross-functional teams to transform hypotheses into impactful Android features, leveraging...
2 weeks ago
Principal Consultant - Informatica MDM Architect
$135K - $160K *
Join a team that's redefining enterprise data management by leading the design and delivery of Informatica MDM solutions. Leverage your expertise to create scalable data models and governance processe...
3 weeks ago
$80K - $95K *
Elevate your career by leading strategic communications across multiple platforms. Collaborate with teams to craft compelling narratives that resonate with diverse audiences while navigating complex r...
Today
$80K - $95K *
Join a team that's dedicated to empowering customers through expert research guidance. You'll lead onboarding, support research initiatives, and enhance decision-making processes, ensuring impactful i...
2 days ago
Partner GTM Programs & Operations Director
$135K - $234K *
Drive partner operations strategies to transform relationships into revenue, enhancing processes and performance frameworks. Collaborate with leadership to integrate AI tools and optimize partner enga...
4 weeks ago
Account Executive, Life Sciences & Medtech
$147K - $220K *
Champion transformative health solutions by managing key client relationships, driving sales, and collaborating across teams to enhance Verily's impact in Life Sciences. Leverage expertise to unlock n...
3 weeks ago
$100K - $120K *
Partner with us to enhance client relationships and drive growth. In this role, you'll manage a diverse portfolio, ensuring customer retention and identifying new opportunities while collaborating wit...
4 weeks ago
Director of Forward Deployed Engineering
$150K - $180K *
Lead the charge in developing innovative AI-driven solutions by managing a dual-function team of engineers and data scientists, enhancing customer engagements, and optimizing delivery models for impac...
Reposted 3 weeks ago
Department Manager, Data Engineering & AI
$150K - $180K *
Lead the charge in transforming enterprise Data Engineering & AI delivery, driving innovation through shared capabilities and scalable solutions. Collaborate across teams to ensure seamless integratio...
1 week ago
Security Engineer, Nation State
$150K - $180K *
Shape the future of security by leading cross-functional initiatives to enhance incident detection and response capabilities. Collaborate with diverse teams to identify risks, develop automation, and...
4 weeks ago
Salesforce Senior Business Analyst
$110K - $150K *
Empower your career by leading client engagements and analysis within our dynamic Salesforce practice. Collaborate with a supportive team to deliver innovative solutions that address current challenge...
Reposted 1 week ago
Sr. Advisory Consultant, Data Governance
$110K - $130K *
Take ownership of data governance by facilitating alignment among stakeholders, executing metadata management, and coaching teams on sustainable stewardship practices. Drive data quality and complianc...
Reposted 4 weeks ago
$90K - $132K *
Join a team that's redefining network infrastructure for healthcare solutions. You'll design, implement, and support advanced wired and wireless networks, ensuring seamless connectivity and optimal pe...
Reposted 6 days ago
Software Engineer, AI/ML Infrastructure (US-Based)
$123K - $159K *
Build core AI platform capabilities that empower teams to develop, run, and scale GenAI applications, collaborating across the tech stack to deliver impactful solutions for millions of users in a fast...
Reposted 2 weeks ago
$150K - $180K *
Drive mobile engineering excellence across diverse product teams, ensuring strategic direction, fostering collaboration, and enhancing delivery. Lead managers, shape architecture, and cultivate a prod...
2 weeks ago
FS Salesforce Data 360 and AI Architect Manager
$94K - $266K *
Architect enterprise-scale Data 360 and AI solutions for Financial Services, leading design sessions and ensuring scalable architecture across Banking, Capital Markets, and Insurance while mentoring t...
4 days ago
$135K - $160K *
Architect robust Kubernetes solutions to enhance cloud infrastructure. Drive multi-cloud initiatives and implement cell-based architecture for scalable, reliable services. Join a team dedicated to bui...
4 weeks ago
Security Engineer - DLP and Insider threat
$105K - $149K *
Drive security excellence by enhancing data protection and detection capabilities. Collaborate with cross-functional teams to implement DLP policies, automate processes, and ensure enterprise systems...
Reposted 5 days ago
Director of IT & Automation - Appen
$140K - $150K *
Shape the future of IT by leading a high-performing team to integrate AI and automation, enhance operational efficiency, and drive strategic technology initiatives in a dynamic environment...
3 weeks ago
$120K - $145K *
Innovate with us as you drive research initiatives, develop ML models, and translate complex algorithms into practical solutions, collaborating across teams to enhance fraud detection and authenticati...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.