Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Analytics Advisor III (R-19951)
$110K - $130K *
Unlock potential by driving analytics and AI solutions for clients, managing a $10M+ portfolio. Collaborate with sales teams to identify opportunities, build value stories, and achieve aggressive sale...
2 weeks ago
AI Infrastructure Engineer [Senior]
$150K - $180K *
Transform AI infrastructure by designing and maintaining production-grade systems across multiple cloud providers. Engage in hands-on architecture decisions, ensuring reliability, security, and automa...
5 days ago
Federal Senior Product Analytics Engineer
$142K - $186K *
Deliver trusted, governed product data by designing scalable ELT pipelines and analytics models. Collaborate across teams to ensure data quality and compliance, empowering stakeholders with self-servi...
2 weeks ago
Expert Commercial Data Scientist
$133K - $188K *
Transform data into actionable insights by leading AI-driven solutions that enhance consumer engagement and drive business growth. Collaborate with cross-functional teams to operationalize advanced an...
4 days ago
Senior Data Scientist I, Growth & Engagement
$159K - $188K *
Unlock potential by leveraging data to drive product decisions and enhance user engagement. Collaborate across teams to design experiments, develop predictive models, and influence product strategies...
1 week ago
Senior Consultant 1, Analytics
$80K - $100K *
Transform your career with this client-facing role, leveraging your expertise in analytics tools like Google Analytics and Tag Manager to deliver strategic solutions and enhance data-driven decision-m...
Reposted 2 weeks ago
$180K - $220K *
Help us optimize healthcare data processes by designing and managing robust data pipelines. You'll integrate legacy systems into a unified platform, ensuring data quality and operational efficiency in...
Today
$108K - $157K *
Optimize data-driven strategies by transforming raw analytics into actionable insights. Collaborate with cross-functional teams to enhance marketplace dynamics and drive measurable business outcomes i...
2 weeks ago
$162K - $170K *
Drive advanced machine learning solutions as a key contributor to our perception team, focusing on deep learning and computer vision to enhance robotics technology and bring innovative models from ide...
Reposted 4 days ago
Business Intelligence Analyst - Snowflake, Databricks, SSRS
$71K - $119K *
Elevate your career by developing innovative BI solutions that enhance reporting workflows and support decision-making in healthcare education. Collaborate with stakeholders to modernize reporting and...
Reposted 1 week ago
$79K - $105K *
Develop and implement strategies to manage financial and compliance risks in a dynamic payments environment. Analyze transaction patterns to identify risks and collaborate with teams to enhance fraud...
Reposted yesterday
Software Engineer - ML Ops (R37)
$140K - $270K *
Unlock your potential by managing ML systems at scale, ensuring uptime and observability. Collaborate on deploying and scaling models, while enhancing platform reliability through advanced engineering...
3 weeks ago
$120K - $145K *
Join a team that's redefining data engineering by building scalable data systems and interfaces. You'll design data models, develop real-world use cases, and ensure reliable data flows, all while writ...
3 weeks ago
$104K - $174K *
Unlock your potential by developing and implementing advanced analytics and AI solutions. Collaborate with cross-functional teams to translate complex data into actionable insights, driving business a...
5 days ago
Software Engineering - Lead Data Scientist
$138K - $165K *
Shape the future of consumer applications by leading machine learning and Generative AI initiatives. Build robust data pipelines, develop and deploy models, and drive business impact through experimen...
5 days ago
Principal Machine Learning Engineer (Memory & Context)
$199K - $334K *
Champion the architecture and engineering of agent memory systems, leading the development of context-driven AI agents. Drive innovation and technical direction while collaborating across teams to enh...
2 weeks ago
Senior AI/ML Data Model Architect
$204K - $216K *
Unlock potential by designing robust data models that empower AI systems. You will ensure data coherence and quality, bridging knowledge representation and machine learning across diverse communities...
Reposted 5 days ago
$140K - $270K *
Unlock potential by designing and deploying scalable AI systems that transform healthcare workflows. Collaborate with cross-functional teams to solve complex business challenges and drive measurable o...
3 weeks ago
Senior Data Scientist I, Monetization
$159K - $188K *
Transform audience and measurement products by independently owning the full lifecycle, from problem framing to delivery. Collaborate with cross-functional teams to enhance data-driven advertising sol...
Reposted today
$95K - $115K *
Elevate global economic insights by leveraging advanced analytics and machine learning to model and predict commodity market dynamics. Collaborate with cross-functional teams to transform complex data...
Reposted 1 week ago
Senior Statistical Programmer Analyst - T
$136K - $239K *
Unlock your potential by leading statistical programming efforts in clinical trials. Collaborate with cross-functional teams to analyze and report clinical data, ensuring compliance with industry stan...
2 weeks ago
$120K - $145K *
Unlock potential by designing and implementing innovative knowledge graph solutions for healthcare data. Collaborate with cross-functional teams to translate complex requirements into scalable, produc...
1 week ago
Media & Marketing Data Scientist
$80K - $95K *
Drive your career with a dynamic role focused on data analysis and visualization across digital marketing channels. Collaborate with teams to create impactful dashboards and predictive models that enh...
Reposted 2 weeks ago
Data Analyst (Databricks) REMOTE
$80K - $95K *
Join a team that's dedicated to transforming healthcare data into actionable insights. This role involves analyzing complex datasets, collaborating with stakeholders, and delivering data-driven recomm...
3 weeks ago
$95K - $115K *
Accelerate progress at the intersection of marketing and data analytics. As a key player, you'll build reporting functions, define KPIs, and drive insights that empower teams across the organization t...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.