Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$110K - $130K *
Optimize data-driven decision-making by leading a team focused on complex analysis and reporting. Drive insights that enhance operational efficiency and inform strategic initiatives across various dep...
1 week ago
Databricks Solution Architect (Data & AI)
$145K - $175K *
Innovate by designing and delivering advanced data and AI platforms on Databricks. Collaborate with clients and teams to shape solutions, optimize architectures, and drive successful implementations f...
2 weeks ago
Demand Side Management Analyst
$80K - $95K *
Analyze energy efficiency and demand response programs while collaborating with a diverse team. Utilize data analysis to provide insights, recommendations, and drive improvements for utilities across...
Reposted 1 week ago
Electrification Services Application Engineer
$98K - $157K *
Lead the charge in delivering cutting-edge technical solutions for energy systems. Collaborate with commercial teams to drive business growth and develop impactful field service proposals across a div...
Reposted 2 weeks ago
$120K - $180K *
Transform biological imaging with your expertise in AI and microscopy. Collaborate with engineers and scientists to define expert reasoning, curate datasets, and build analysis pipelines that set the...
2 weeks ago
$83K - $222K *
Transform data engineering practices by designing robust data pipelines and models. Collaborate with cross-functional teams to enhance analytics capabilities and ensure data quality, governance, and p...
5 days ago
Principal Technical Marketing Engineer | US | Remote
$183K - $220K *
Elevate technical storytelling by creating impactful demos and workshops that bridge the gap between product capabilities and customer understanding, empowering sales teams and enhancing buyer engagem...
1 week ago
Senior Solution Consultant, Cloud Platform and AI
$120K - $145K *
Transform customer experiences by delivering expert guidance on Atlassian Cloud and AI solutions. Collaborate with clients to solve complex challenges, drive value realization, and expand service oppo...
1 month ago
$110K - $130K *
Elevate client success by managing complex projects, ensuring timely delivery, and maintaining budget integrity. Collaborate with diverse teams to drive engagement and optimize project outcomes from i...
3 weeks ago
$93K - $116K *
Empower integrated marketing campaigns with a focus on account-based marketing. Collaborate with Sales to prioritize accounts, align messaging, and drive pipeline growth while managing multi-channel c...
1 week ago
$94K - $157K *
Unlock potential by joining our team as a Data Analyst, where you'll leverage your expertise in data manipulation and visualization to support key Federal clients, driving impactful solutions through...
5 days ago
$117K - $195K *
Drive impactful data analysis and visualization for a key Federal client, leveraging big data techniques and statistical methods to deliver actionable insights and solutions. Collaborate with a dynami...
Reposted 6 days ago
$100K - $170K *
Unlock potential by providing architectural engineering support for DOJ/BOP facilities. Collaborate on technical analyses, document reviews, and design recommendations to enhance decision-making and p...
3 weeks ago
Senior Digital Program Manager
$92K - $136K *
Help us drive customer success by owning and optimizing digital engagement programs. You'll lead strategy, build automated journeys, and analyze performance to enhance customer experiences and ensure...
Reposted today
$160K - $185K *
Unlock your potential by leading a dynamic team to drive channel partnerships, transforming opportunities into revenue-generating relationships across diverse verticals in a fast-growing ecosystem...
1 week ago
Commerce Media Strategist, Amazon DSP (Full Funnel)
$80K - $95K *
Elevate client success by crafting and optimizing innovative commerce media strategies. Leverage data-driven insights to enhance campaign performance across platforms, ensuring measurable growth and c...
1 week ago
Staff Biostatistician (Clinical Validation)
$164K - $205K *
Lead the design and analysis of clinical validation studies, ensuring regulatory compliance and driving innovative research in molecular diagnostics. Collaborate with cross-functional teams to enhance...
2 weeks ago
$80K - $95K *
Join a dynamic team as you oversee laboratory operations, ensuring quality control and efficient management of departments while supporting patient care through diagnostic services and staff guidance...
1 week ago
$150K - $204K *
Lead the design and implementation of innovative IT solutions, driving transformation for enterprise clients while ensuring alignment with business goals. Collaborate across teams to craft technical s...
Reposted 4 weeks ago
Senior Bioinformatics & Genomics Data System Engineer
$113K - $142K *
Elevate your career by joining our dynamic team to design, develop, and optimize bioinformatics software tools and systems, ensuring robust functionality and compliance in a fast-paced, innovative env...
5 days ago
Senior Data Engineer II - Data Platforms
$175K - $225K *
Transform data engineering practices by architecting scalable platforms, driving reliability, and mentoring teams. Lead cross-functional initiatives to enhance data governance and leverage AI tools fo...
1 week ago
Analyst- Classification, Import/Export
$83K - $114K *
Unlock potential by driving regulatory compliance and optimizing trade processes. Collaborate with diverse teams to ensure accurate tariff classifications and effective communication with stakeholders...
1 week ago
Analyst- Classification, Import/Export
$83K - $114K *
Analyze and optimize tariff classification processes while ensuring compliance with government regulations. Collaborate with diverse teams to enhance decision-making and drive business effectiveness t...
1 week ago
Process Engineer - Life Sciences
$110K - $130K *
Join a dynamic team to define and design life sciences manufacturing processes, ensuring compliance and efficiency in facility layouts. Collaborate with multidisciplinary teams to translate complex re...
1 week ago
Senior Success Lead, Public Sector
$140K - $175K *
Empower your career by driving impactful relationships in government sectors. Manage a dedicated account portfolio, enhance customer satisfaction, and lead strategic engagement initiatives to maximize...
4 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.