Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Lead Engineer Automation Quality
$105K - $149K *
Transform the future of automation by leading the development of innovative testing strategies and frameworks. Collaborate with teams to ensure high-quality deliverables through effective automation p...
Reposted yesterday
Senior Director, Data Architecture
$150K - $180K *
Champion enterprise data architecture by establishing standards and a unified data catalog. Collaborate across teams to define metrics and ensure data governance, driving alignment and clarity in a ha...
3 weeks ago
Staff Developer Platform Engineer
$183K - $200K *
Transform the Developer Platform by enhancing infrastructure and deployment processes. Collaborate with teams to ensure safe, efficient product delivery while driving adoption of innovative tooling an...
2 weeks ago
GIS Software Quality Assurance Engineer
$95K - $120K *
Champion quality assurance in GIS software by developing test plans, validating data, and ensuring reliability for Army geospatial applications. Collaborate with experts to enhance automated testing p...
2 weeks ago
Applied AI Health Data System Engineer-Senior Manager
$124K - $280K *
Unlock potential by leading AI and ML solutions in healthcare, driving innovation and operational efficiency. Collaborate with diverse teams to translate complex challenges into impactful outcomes thr...
Reposted 2 weeks ago
Senior Frontend Engineer, Ads Formats
$190K - $267K *
Drive impactful ad experiences by leveraging your frontend expertise in JavaScript and TypeScript. Collaborate with cross-functional teams to enhance user engagement and optimize ad performance across...
5 days ago
$110K - $130K *
Develop reliable backend systems and platforms that empower engineers. Own capabilities from design to production, enhance performance, and collaborate across teams to improve developer experience and...
Yesterday
$120K - $145K *
Contribute to the development of a robust Kubernetes control plane, enhancing multi-cloud infrastructure and driving scalable architecture for enterprise-grade cloud services...
4 weeks ago
$183K - $203K *
Drive the integration of AI analytics and data platforms, ensuring decision-ready products through collaboration and technical leadership. Lead cross-functional teams to establish quality controls and...
4 weeks ago
Account Manager, Consulting & Professional Services
$100K - $120K *
Deliver exceptional client engagement by managing relationships and driving growth within a diverse portfolio. Collaborate with teams to maximize retention and uncover new opportunities, ensuring clie...
4 weeks ago
AI First Sr. Android Developer
$125K *
Transform the future of mobile development by leveraging AI to enhance marketplace experiences. Collaborate with cross-functional teams to design, build, and ship high-quality Android applications tha...
3 weeks ago
$182K - $325K *
Empower the GTM AI Engineering team by building innovative AI solutions that enhance sales and customer success workflows. Lead strategy and hands-on development, ensuring reliable, impactful AI produ...
3 days ago
Senior Financial Analyst, FP&A
$110K - $130K *
Advance your career by owning corporate FP&A, driving financial insights, and partnering with leaders across functions to enhance strategic planning and reporting in a dynamic growth-stage environment...
2 weeks ago
Transformation Analyst, Emerging Technologies
$73K - $87K *
Unlock potential by driving transformation through emerging technologies. Collaborate with stakeholders to analyze, prototype, and implement AI solutions that address real-world challenges, ensuring h...
2 days ago
Senior Business Systems Analyst - Healthcare Payor Specialized
$81K - $142K *
Lead the design and development of enterprise data management solutions, collaborating with stakeholders to analyze requirements and enhance data processing capabilities using advanced technologies in...
1 week ago
Global Cloud Migration Developer
$108K - $130K *
Unlock potential by leading the development of AI-driven test automation frameworks for cloud migration, ensuring seamless transitions for enterprise imaging customers while collaborating with enginee...
3 days ago
AI Native Delivery Manager (AI/Run practice)
$120K - $145K *
Grow your career with a dynamic role leading AI Native pods, managing cross-functional teams through education and client engagements, while championing AI SDLC practices and ensuring delivery excelle...
2 weeks ago
Director, Operations Analytics & Workforce Strategy
$125K - $150K *
Join a dynamic team to drive operational excellence through data-driven strategies. Lead workforce planning, enhance performance metrics, and collaborate across functions to optimize patient services...
1 week ago
$175K - $215K *
Transform client engagement by driving strategic growth and satisfaction through strong relationships and consultative solutions. Collaborate with cross-functional teams to deliver measurable business...
Yesterday
$175K - $215K *
Lead the charge in driving strategic growth and client satisfaction by managing senior-level relationships, leveraging cross-functional resources, and delivering measurable business value within a por...
5 days ago
$105K - $115K *
Optimize security measures by leading technical solutions to mitigate information risks. Ensure compliance with corporate policies and oversee incident response, safeguarding all computing platforms a...
3 weeks ago
$120K - $145K *
Join a dynamic finance team as you oversee financial reporting, manage reconciliations, and enhance accounting processes. Your expertise will ensure compliance with GAAP while supporting audits and op...
Reposted 1 week ago
Senior Technical Marketing Manager, AI
$120K - $145K *
Unlock potential by driving AI security marketing initiatives, creating demos, and collaborating with cross-functional teams to enhance product visibility and adoption. Serve as the technical voice fo...
5 days ago
Senior Manager, Software Engineering
$225K - $265K *
Partner with us to lead a high-performing engineering team, driving innovation and efficiency in our travel marketplace. You'll manage project lifecycles, enhance collaboration, and champion a custome...
2 weeks ago
$122K - $204K *
Unlock insights as you lead market research initiatives, driving strategic decisions through data storytelling and customer understanding. Collaborate with stakeholders to enhance brand strategies and...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.