Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Sr. Engineer, AI Cyber Security
$140K - $187K *
Innovate the future of AI security by designing and implementing robust defenses against adversarial threats, ensuring the integrity of AI systems while fostering innovation and collaboration across c...
3 weeks ago
$141K - $234K *
Transform healthcare analytics by leveraging advanced statistics and machine learning to uncover insights from complex datasets. Collaborate with experts to innovate and develop data-driven solutions...
Reposted 4 weeks ago
$110K - $130K *
Join a dynamic team to enhance system reliability and performance through automation, ensuring minimal downtime and optimal user experience while driving continuous improvements in a cutting-edge tech...
1 week ago
$110K - $130K *
Drive operational excellence by enhancing system reliability and automation. Collaborate with teams to minimize downtime, optimize performance, and implement innovative solutions that ensure high avai...
1 week ago
Associate Solution Engineer | SaaS Conversions
$62K - $100K *
Drive SaaS conversion initiatives by collaborating with teams to assess risks, readiness, and opportunities. Engage with customers to facilitate migrations and ensure effective communication throughou...
5 days ago
Enterprise Account Executive, Media Intelligence
$99K - $110K *
Accelerate progress at winning new enterprise customers by leveraging your expertise in complex SaaS solutions. Drive revenue growth and build executive relationships while navigating intricate sales...
Yesterday
$80K - $95K *
Transform customer data integration by configuring and validating mappings between third-party systems and applications. Collaborate with teams to ensure seamless onboarding and ongoing support, enhan...
Yesterday
Research Engineer - Agentic Audio ML Workflows
$120K - $145K *
Elevate audio ML research by designing workflows that automate experiments, enhance reproducibility, and optimize GPU resources. Collaborate with researchers to streamline processes and deliver impact...
Reposted today
Customer Success Architect (AI)
$110K - $130K *
Shape the future of customer success by driving AI adoption through tailored solutions. Collaborate with enterprise teams to unlock high-impact use cases, ensuring measurable business value and operat...
1 week ago
Automation Control Engineer Consultant
$85K - $102K *
Drive manufacturing modernization by leading technical projects, solving complex problems, and enhancing client relationships. Collaborate with teams to develop innovative solutions and ensure project...
2 days ago
$127K - $223K *
Analyze channel performance and drive data-driven decisions by building models, validating vendor claims, and proactively answering business questions to enhance offline and direct mail strategies...
Reposted today
$72K - $94K *
Contribute to program success by planning, coordinating, and executing activities. Collaborate with teams and stakeholders to monitor progress, manage risks, and analyze data, ensuring objectives are...
4 days ago
$184K - $314K *
Elevate executive recruiting by leading VP-level searches, advising C-suite leaders, and shaping talent strategies. Drive high-impact hiring decisions while managing multiple confidential searches in...
Today
$135K - $160K *
Transform the autonomy simulation platform by migrating to NVIDIA Omniverse, stabilizing the current system, and enhancing data pipelines for effective testing and training of perception models at sca...
Today
$120K - $145K *
Unlock potential by designing and optimizing cloud-based data platforms, ensuring scalability and performance across relational, NoSQL, and vector databases while collaborating with AI and engineering...
Reposted yesterday
$113K - $170K *
Lead the charge in transforming customer integrations by driving technical discovery, scoping complex implementations, and ensuring successful onboarding for high-stakes accounts. Collaborate closely...
2 weeks ago
Quality Analyst - Outpatient, Healthcare
$85K - $92K *
Join our team to enhance healthcare quality through precise coding audits, mentoring coders, and driving process improvements. Your expertise will help shape compliance and accuracy in outpatient serv...
1 week ago
Adobe target Architect - MarTech
$110K - $130K *
Transform the future of digital engagement by leading Adobe Target implementations. Collaborate across teams to develop personalized strategies that enhance user experiences and drive measurable busin...
6 days ago
Manager, Technology, Data and AI Advisory, Energy & Utilities
$125K - $150K *
Transform the energy & utilities landscape by leading OT and infrastructure workstreams throughout the private equity investment lifecycle, driving diligence, integration, and value creation for criti...
6 days ago
$96K - $130K *
Join a dynamic team to shape innovative fundraising tools that empower progressive campaigns and nonprofits. Leverage modern technologies to enhance election readiness and compliance, while mentoring...
Reposted 1 week ago
$99K - $139K *
Join a dynamic team to develop and maintain innovative web applications, enhancing user experience and security. Collaborate with stakeholders to gather requirements, create documentation, and ensure...
Today
Field Application Engineer - Data Center Solutions
$96K - $205K *
Empower the Data Center Solutions team by providing expert technical support, evaluating customer needs, and leading strategic projects across the Central US and Latin America, ensuring optimal produc...
1 week ago
Regulatory Strategy Consultant
$125K - $150K *
Drive regulatory strategy across major programs, leading high-impact submissions and authority engagement. Collaborate with cross-functional teams to optimize clinical development and ensure complianc...
2 weeks ago
$80K - $95K *
Join a team that's driving innovation in actuarial analysis. You'll tackle complex projects, conduct risk assessments, and mentor junior analysts, all while collaborating in a dynamic hybrid work envi...
Reposted 4 days ago
AI First iOS Software Engineer (Remote)
$85K - $125K *
Accelerate progress at the forefront of mobile development by leveraging AI tools to enhance iOS applications. Collaborate with cross-functional teams to deliver high-quality, customer-centric marketp...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.