Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$130K - $160K *
Create impactful solutions as a Senior Product Engineer, owning projects from concept to delivery. Collaborate with a dynamic team, leveraging AI tools to enhance development while mentoring peers and...
5 days ago
$100K - $140K *
Shape the future of financial markets as an Operations Risk Analyst, ensuring the stability of trade processes, monitoring risk exposure, and collaborating across teams to enhance operational resilien...
Reposted today
Principal Engineer, Agentic AI
$150K - $180K *
Empower innovation by architecting next-gen AI-driven CRM solutions. Lead a dynamic team to optimize data processing, enhance automation, and deliver exceptional user experiences while driving market...
4 days ago
$96K - $116K *
Champion innovative medical policy solutions by analyzing data, ensuring quality, and collaborating across clinical operations. Drive enhancements in payment policy management while supporting diverse...
2 weeks ago
Senior Engineer, Partner Integrations Platform
$145K - $160K *
Drive innovation by building scalable data integration solutions, collaborating with cross-functional teams to enhance healthcare technology. Ensure data quality and security while optimizing performa...
6 days ago
Experienced Civil Engineer - Data Center
$77K - $102K *
Lead the charge in delivering innovative civil engineering solutions for large-scale data center projects. Collaborate with multidisciplinary teams while developing your skills and expertise in a supp...
Reposted 1 week ago
Senior Backend Engineer, Admin Experience
$199K - $235K *
Champion the development of secure backend services and APIs, enhancing user administration capabilities. Collaborate across teams to ensure reliable, high-quality software while mentoring peers and d...
Today
Principal Applied Scientist (User Modeling)
$195K - $312K *
Advance user modeling by driving complex AI projects end-to-end, collaborating with cross-functional teams to translate cutting-edge research into impactful solutions for home shopping experiences...
2 weeks ago
$88K - $121K *
Join a team that's redefining financial analytics by developing cutting-edge predictive models. Collaborate globally, analyze large datasets, and drive impactful solutions in the financial services in...
3 weeks ago
$90K - $120K *
Join a team that's dedicated to advancing process engineering in Life Sciences. Lead complex design projects, collaborate with multidisciplinary teams, and mentor junior engineers while enhancing your...
6 days ago
$85K - $100K *
Join a dynamic team as you drive data integrity and enhance client reporting through Addepar. Leverage your analytical skills and operations experience to support private investment processes and coll...
1 week ago
Measurement Lead, Marketing Science
$110K - $130K *
Partner with us to drive data-informed marketing strategies and optimize measurement practices. Leverage your analytics skills to guide clients, enhance performance, and manage a talented team while f...
Reposted 4 days ago
$218K - $273K *
Champion the global technical alliance with Snowflake and Databricks, driving co-sell revenue through strategic planning, technical narratives, and collaborative execution across teams and events, whi...
3 weeks ago
Senior Manager - APR DRG Concept Development Analyst
$100K - $125K *
Transform healthcare analytics by leading the development of APR-DRG audit criteria. Collaborate with cross-functional teams to enhance payment integrity through data-driven insights and innovative so...
2 weeks ago
Social Media Manager, Predictions
$140K - $164K *
Join us to elevate brand presence by crafting engaging, real-time content across social platforms. Collaborate with teams to launch campaigns, analyze trends, and optimize strategies that resonate wit...
2 weeks ago
Senior Decision Intelligence Engineer
$106K - $147K *
Champion the development of ML pipelines, ensuring scalable, reliable decision-making systems that optimize member outcomes while collaborating with cross-functional teams to enhance platform performa...
Reposted 4 days ago
$120K - $145K *
Drive the enterprise adoption of AI capabilities, managing product strategy and governance for agent solutions. Collaborate across teams to ensure innovation aligns with security, compliance, and oper...
4 days ago
Continuous Service Improvement/Operational Excellence Analyst
$76K - $105K *
Support day-to-day operations for investment teams, collaborating across functions to enhance processes, manage budgets, and drive special projects from planning to implementation, ensuring alignment...
Yesterday
Sr Director Analyst, Data Management for AI Enablement
$172K - $202K *
Champion innovative insights and strategies as a Senior Director, driving impactful research and analysis to empower clients globally. Engage with stakeholders to deliver actionable advice and elevate...
1 week ago
Director of Engineering, Data Products
$223K - $290K *
Lead the technical strategy for data products, driving clinical data capabilities and insights. Collaborate with teams to optimize data ingestion processes and implement AI-assisted development workfl...
Reposted today
Marketing Technology & Platform Lead
$140K - $170K *
Lead the charge in optimizing our marketing technology ecosystem, ensuring seamless integration and support across platforms. Collaborate with cross-functional teams to translate business needs into e...
3 weeks ago
Principal Data Platform Engineer
$160K - $185K *
Shape the future of data engineering by leading the architecture and evolution of a robust enterprise data platform, ensuring reliability and integration across analytics, reporting, and AI capabiliti...
3 weeks ago
$115K - $130K *
Join a team that's dedicated to developing innovative web and cloud applications. In this role, you'll lead projects, mentor junior engineers, and collaborate with cross-functional teams to deliver hi...
Reposted 1 week ago
Palantir - Sales Capture Associate Director
$169K - $267K *
Lead the charge in driving innovative sales strategies across diverse industries, targeting a $32M+ annual sales goal. Collaborate with ecosystem partners to deliver AI-driven solutions that address c...
2 weeks ago
Technical Commerce & AI Consultant | Agentic Commerce
$70K - $235K *
Unlock innovative AI-driven commerce solutions by designing and implementing multi-agent systems. Collaborate with clients to ensure scalable, secure deployments that align with business objectives an...
Reposted today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.