Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$90K - $113K *

Transform data management processes by bridging business needs with technical execution. Support data pipeline maintenance, ensure data quality, and assist in BI reporting to enhance operational effic...

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$180K - $210K *

Lead the charge in transforming people analytics by applying causal inference and advanced statistical methods to drive strategic decisions on recruitment, retention, and compensation across the organ...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$125K - $147K *

Join a team that's redefining revenue operations by enhancing visibility and accountability across the customer journey. Collaborate with marketing and sales to build insightful reporting and drive da...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$144K - $165K *

Unlock potential by owning data architecture and reliability across domains. Collaborate with an AI-first team to design robust data pipelines, enhance analytics, and drive impactful solutions in a dy...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $160K *

Elevate your career by joining a dynamic team as a Data Engineer, owning end-to-end data systems and driving platform modernization. You'll improve data reliability and work closely with cross-functio...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$124K - $145K *

Join our Client Insights team to transform data into actionable insights that drive sales and merchant retention. Collaborate across analytics, product, and strategy to enhance AI-driven solutions for...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$192K - $226K *

Join a team that drives insights through data science, optimizing mobile marketing efforts and maximizing user engagement. Collaborate cross-functionally while employing advanced analytics and measure...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Consumer Technology

$90K - $110K *

Analyze healthcare data to enhance clinical insights and improve medication use. Collaborate with cross-functional teams to develop analytics tools and real-world evidence studies, driving better heal...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$128K - $153K *

Join a team that's shaping the future of technology by delivering impactful software solutions. Collaborate on innovative projects, optimize data operations, and enhance user experiences while support...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Elevate your career as a Senior Data Engineer, driving innovation in cloud-native data pipelines and architectures. Leverage your expertise in structured credit and financial analytics to modernize da...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$94K - $293K *

Transform data engineering practices by leading modernization efforts, focusing on batch and streaming pipelines, AI-ready data, and governance frameworks to ensure trust and quality in data consumpti...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$466K - $500K+*

Elevate your career by building a cutting-edge ML data platform that enhances productivity for ML practitioners. Collaborate with experts to create innovative solutions for feature computation and sha...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$110K - $130K *

Join a team that's dedicated to transforming healthcare data solutions. As a Senior Data Engineer, you'll enhance complex systems, collaborate across departments, and drive analytics to optimize finan...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$73K - $212K *

Lead innovative AI solutions as a Manager in Data and Analytics Engineering. Supervise teams, manage client accounts, and drive exceptional results while fostering relationships and embracing technolo...

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$170K - $190K *

Engineer data strategies and methodologies for emerging sectors, transforming complex datasets into actionable insights. Lead a team while collaborating cross-functionally to enhance data accuracy and...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$135K - $145K *

Innovate data solutions by building and maintaining robust pipelines that empower critical processes. Collaborate with engineers and stakeholders to enhance data reliability and efficiency in a high-t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Unlock potential by leveraging data science to drive informed decision-making through advanced analytics, modeling, and collaboration in a dynamic research environment...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$70K - $196K *

Support data modernization and AI solutions on GCP by building pipelines, collaborating with clients, and implementing ML models. Contribute to architecture design and ensure data quality while learni...

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$124K - $140K *

Lead data analytics initiatives by defining priorities and timelines to deliver actionable insights and research projects. Collaborate with cross-functional teams to enhance data-driven decision-makin...

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$182K - $252K *

Drive impactful marketing measurement by leveraging causal inference to optimize budget allocation across channels. Collaborate with cross-functional teams to ensure data-driven decisions enhance grow...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Empower innovation by partnering with data science to build and maintain robust ML pipelines. Drive automation and observability in production systems, ensuring reliable match data at scale while coll...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$135K - $160K *

Lead the SAP Analytics strategy and implementation, driving innovation in analytics solutions. Collaborate with stakeholders to deliver insights and manage teams, ensuring successful deployment of SAP...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$230K - $322K *

Lead the development of machine learning models to enhance advertiser insights, optimizing campaign performance through advanced forecasting and scenario analysis. Collaborate across teams to drive im...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Media

$95K - $115K *

Drive data-driven decision-making by transforming complex data into actionable insights. Collaborate with cross-functional teams to enhance reporting and analytics using advanced SQL and AI tools, ens...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $120K *

Transform creative performance analysis by owning insights and recommendations for high-stakes accounts. Collaborate across teams to enhance workflows and drive impactful results in a fully remote env...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.