Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Staff Machine Learning Engineer(Platform - Identity)
$218K - $256K *
Lead the end-to-end execution of ML systems for identity verification, ensuring the integrity of millions of accounts through advanced models and cross-team collaboration, while mentoring engineers an...
Reposted 6 days ago
$154K - $232K *
Transform enterprise cloud strategies by leading large-scale migrations to Azure and AWS. Collaborate with global teams to establish architecture standards, ensure security, and drive innovative solut...
5 days ago
$90K - $110K *
Unlock potential by enhancing revenue operations through data-driven workflows, improving systems, and automating processes. Collaborate with cross-functional teams to ensure efficiency and scalabilit...
2 weeks ago
$127K - $224K *
Drive impactful product modeling and marketing measurement as a Staff Data Scientist. Own the lifecycle of ML models, collaborate with PMs, and communicate insights effectively to enhance user experie...
Today
$135K - $160K *
Optimize our IT operations and GRC framework, ensuring seamless integration while managing compliance and security practices. Lead teams, drive audit readiness, and build a resilient infrastructure to...
Reposted 1 week ago
$160K - $180K *
Unlock potential by leading product marketing initiatives that empower healthcare teams. Drive sales enablement, module marketing, and customer expansion, while shaping messaging and content that reso...
3 weeks ago
Lead Forward Deployed Engineer (AI Enablement)
$194K - $272K *
Elevate AI solutions by leading engineering efforts that transform business workflows. Collaborate with teams to identify opportunities, prototype solutions, and implement scalable AI applications tha...
2 weeks ago
$80K - $95K *
Transform energy solutions by leading diverse projects, conducting analyses, and collaborating with clients. Utilize engineering expertise to drive efficiency and sustainability in various sectors, en...
1 month ago
Senior Software Engineer, AI Automation
$130K - $195K *
Join a dynamic AI Automation team to design and deliver production-grade AI agents and workflows, enhancing operational efficiency across the organization while solving complex business challenges wit...
1 week ago
$84K - $87K *
Join us as a Data Operations Engineer, where you'll develop and manage data systems for healthcare claims processing. Collaborate with teams to ensure data accuracy and optimize ETL/ELT pipelines whil...
Reposted 3 weeks ago
$156K - $180K *
Empower clients by owning technical relationships for the Enterprise Suite, guiding them from discovery to implementation. Collaborate with teams to enhance adoption and resolve issues, ensuring seaml...
2 weeks ago
Manager, Software Engineering - Engineering Tools
$120K - $148K *
Join a team that's shaping the future of AEC software by leading engineering talent and enhancing workflows. Drive innovation in Autodesk Revit add-ins and tools while fostering a collaborative enviro...
2 weeks ago
Senior AI Product Engineer, Backend
$125K - $225K *
Join a team that's driving innovation in AI by developing scalable backend systems in Go, Python, and Java. Tackle complex challenges while enhancing distributed architectures to empower high-performa...
Reposted 4 days ago
$60K - $120K *
Unlock potential by deploying and supporting advanced robotic systems in diverse environments. Collaborate with teams, troubleshoot issues, and enhance client experiences through effective communicati...
4 weeks ago
$135K - $160K *
Engage in designing and optimizing AI solutions to enhance automation and analytics, collaborating across teams to integrate advanced AI capabilities into core products, while ensuring ethical standar...
1 week ago
$145K - $165K *
Drive your career by owning the end-to-end data platform, designing and maintaining scalable pipelines and infrastructure. Collaborate with analytics teams to ensure data quality and governance while...
1 week ago
Director of Growth Marketing & Analytics
$155K - $192K *
Lead the charge in transforming member acquisition strategies through data-driven insights, optimizing marketing performance, and driving sustainable growth in a fully remote environment. Collaborate...
2 weeks ago
$140K - $160K *
Unlock potential by driving the evolution of AWS environments and CI/CD pipelines, enhancing observability and security, while collaborating with engineers to optimize platform reliability and perform...
6 days ago
$150K - $185K *
Unlock potential by driving innovative infrastructure solutions for scalable deployments, collaborating with customers to refine requirements, and enhancing operational efficiency through automation a...
Reposted 4 days ago
Manager, Software Engineering - AI Tools
$120K - $150K *
Join a team that's shaping the future of AI engineering by leading a dynamic group of engineers and Technical Leads. Drive workforce strategy, enhance team capabilities, and ensure sustainable deliver...
2 weeks ago
Account Director, Medical Imaging and SS
$110K - $130K *
Advance your career by driving business development in clinical research and medical imaging. Build strategic client relationships, identify new opportunities, and contribute to innovative healthcare...
Reposted 2 weeks ago
$125K - $150K *
Elevate your career by driving data engineering excellence in Palantir Foundry, transforming legacy systems into robust pipelines and applications while collaborating with cross-functional teams to de...
3 weeks ago
Data Analytics Manager - Client Legal Services
$100K - $170K *
Drive the evolution of Legal Operations analytics by building scalable data capabilities, modernizing reporting, integrating AI, and establishing predictive models to enhance decision-making and opera...
Reposted 1 week ago
Senior/Staff Full Stack Software Engineer, Frontend Leaning
$135K - $160K *
Elevate user experiences by leading the development of innovative web features. Collaborate with cross-functional teams to deliver high-quality, customer-facing applications using modern technologies...
5 days ago
Infrastructure Engineer - Teradata
$69K - $125K *
Join a team that's dedicated to ensuring the stability and efficiency of Teradata systems. You'll support operations, troubleshoot issues, and collaborate on infrastructure solutions to enhance perfor...
4 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.