Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$120K - $130K *

Join a dynamic team to design and optimize scalable data solutions that enhance healthcare technology platforms. Collaborate with cross-functional teams to ensure data integrity and drive informed dec...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$137K - $231K *

Accelerate your career by architecting data solutions that drive AI and analytics at scale. Collaborate with cross-functional teams to transform complex business challenges into impactful data product...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Unlock potential by leveraging your expertise in data analysis and psychometrics to drive innovative assessment solutions. Collaborate with a dynamic team to enhance educational outcomes through advan...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$207K - $244K *

Shape the financial data landscape by leading analytics initiatives, ensuring accurate, timely reporting and compliance. Collaborate with cross-functional teams to build scalable data pipelines and ma...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$160K - $195K *

Innovate with us to develop and deploy cutting-edge AI solutions that enhance advertising measurement products. Collaborate across teams to drive impactful data-driven decisions and expand our capabil...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$185K - $260K *

Join Reddit's Ads team as a Machine Learning Engineer, where you will design, build, and deploy machine learning models to enhance ad ranking, bidding, and optimization. This hands-on role involves ta...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Media

$99K - $167K *

Develop and maintain robust data pipelines using SparkSQL and Pyspark, ensuring high-quality data for analytics. Collaborate with cross-functional teams to enhance data analysis efficiency and support...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$216K - $303K *

Discover an exciting opportunity to drive innovation in ad optimization and marketplace quality, creating impactful bidding and auction systems that enhance user experience and maximize advertiser suc...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Media

$120K - $130K *

Unlock potential by managing complex datasets to drive decisions across a fast-scaling energy planning function. Collaborate with cross-functional teams to ensure data integrity and operational effici...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Transform the renewable energy landscape by managing data portfolios, analyzing project performance, and enhancing financial reporting. Collaborate with cross-functional teams to drive strategic energ...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Join a team that's building and scaling a data and analytics platform to enhance clinical AI performance. Collaborate with cross-functional teams to create actionable insights and drive improvements i...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $170K *

Transform data into actionable insights by analyzing EV telematics and charging patterns. Collaborate across teams to enhance data quality and drive product innovation, shaping the future of electric...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Energy & Utilities

$80K - $100K *

Unlock insights by analyzing customer and operational data to enhance business outcomes. Collaborate with cross-functional teams to develop dashboards and reports that drive strategic decisions and im...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $145K *

Elevate revenue and risk strategies by leveraging data insights to drive impactful business decisions. Collaborate across teams to optimize processes, influence product development, and enhance client...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$165K *

Engage in cutting-edge AI projects by developing and deploying NLP models. Collaborate with cross-functional teams to optimize performance and scalability, utilizing frameworks like PyTorch or TensorF...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Advance healthcare solutions by developing scalable ML systems, collaborating with cross-functional teams, and driving innovative AI methodologies to enhance patient outcomes and optimize operational...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $120K *

Unlock potential by optimizing commercial processes through AI and analytics. Collaborate with teams to enhance efficiency, forecasting, and decision-making, driving impactful business outcomes across...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$72K - $100K *

Join our dynamic team as a Sr. Credit Analyst, owning the underwriting cycle from application review to decision-making. Leverage your analytical skills to enhance credit processes and contribute to a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Analyze and evaluate AI-generated chatbot responses to enhance accuracy and relevance. Collaborate with stakeholders to document requirements and deliver structured assessments that drive improvements...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Staffing

$140K - $180K *

Transform cancer care by developing AI biomarkers through collaboration with ML scientists and clinical partners, enhancing model robustness and interpretability across diverse datasets to improve pat...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $149K *

Unlock potential by leading healthcare data analytics to enhance hospital quality performance and rankings. Collaborate with teams to design dashboards, mentor analysts, and present insights to execut...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Design and optimize evaluation systems for AI agents, enhancing performance and quality through innovative metrics and benchmarks. Collaborate with cross-functional teams to ensure agents meet user ne...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$180K - $220K *

Drive the end-to-end ML and LLM lifecycle, optimizing AI workflows and automations. Collaborate with cross-functional teams to ensure scalable, reliable production of AI-driven solutions while impleme...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$87K - $293K *

Champion data engineering excellence by leading migration engagements, developing pipelines and data products for AI systems, and applying innovative evidence-extraction techniques to ensure data inte...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$130K - $160K *

Drive the development of autonomous AI systems that enhance decision-making across platforms. Shape AI architecture, integrate tools, and lead the creation of impactful AI solutions from concept to pr...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.