Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Software Engineer 5 - Training Platform, AI Platform
$466K - $500K+*
Join a team that's shaping the future of AI by designing and building scalable platforms for large-scale machine learning model training, enhancing performance, and creating user-friendly experiences...
5 days ago
Staff Machine Learning Engineer, Compliance Automation (Platform)
$218K - $256K *
Elevate compliance operations by architecting AI systems that automate workflows, ensuring accuracy and regulatory adherence while mentoring engineers and driving technical excellence in machine learn...
6 days ago
$115K - $130K *
Drive client growth by leveraging data-driven insights to enhance strategic relationships and deliver impactful solutions. Collaborate cross-functionally to achieve measurable outcomes and ensure clie...
2 weeks ago
$105K - $163K *
Transform database environments by leading architecture and administration efforts across multiple platforms, ensuring compliance and performance for mission-critical applications in a dynamic, remote...
2 weeks ago
Senior Project Controls Analyst
$160K *
Drive the future of project controls by providing expert EVM, cost, and schedule analysis for federal programs. Collaborate with cross-functional teams to enhance decision-making and ensure program co...
Yesterday
Data Science Manager (Full-Stack / Production ML)
$160K - $170K *
Lead and grow a high-performing data science team while delivering full-cycle data solutions. Shape data infrastructure, oversee ML models, and engage with stakeholders to translate business needs int...
Reposted 3 weeks ago
Senior Sales Engineer, Data Products
$125K - $160K *
Join a team that's redefining data solutions by leading technical sales efforts, collaborating with Account Managers, and driving customer success through innovative data architecture and tailored dem...
1 week ago
Business Intelligence Analyst II
$75K - $113K *
Unlock potential by independently managing operational reporting and analytics to enhance performance across a complex fulfillment network, driving actionable insights and improving customer experienc...
3 weeks ago
$72K - $120K *
Lead a multi-disciplinary team in developing machine learning algorithms to enhance clinical decision support, leveraging healthcare datasets for innovation and making vital discoveries that drive pro...
Reposted 4 weeks ago
$94K - $266K *
Lead the charge in transforming customer engagements by managing AWS solutions delivery, ensuring client satisfaction, and driving strategic growth through strong relationships and innovative practice...
3 weeks ago
$180K - $200K *
Lead complex technical initiatives, ensuring scalable, secure solutions while mentoring engineers and driving high standards across the software development lifecycle in a remote, collaborative enviro...
Yesterday
$180K - $200K *
Shape the future of technology as a senior technical leader, driving complex initiatives and mentoring engineers. Collaborate with cross-functional teams to deliver scalable, secure cloud-native solut...
2 weeks ago
$80K - $95K *
Manage HR functions by aligning workforce strategies with company goals, enhancing employee engagement, and ensuring compliance. Oversee recruitment, onboarding, and performance management while foste...
2 weeks ago
$135K - $160K *
Lead a dynamic team to transform AI strategies into impactful healthcare solutions. Oversee engineering execution, guide architecture, and ensure compliance while collaborating with cross-functional p...
5 days ago
Manufacturing Quality Engineer, Data Center Equipment
$110K - $130K *
Transform the quality landscape of data center equipment by overseeing supplier audits, inspections, and continuous improvement initiatives. Collaborate with cross-functional teams to ensure complianc...
3 days ago
Senior Intelligence Analyst - Russia & Eurasia Regional Focus
$120K - $145K *
Explore the complexities of Russian and Eurasian crypto threats, owning end-to-end attribution and analysis. Collaborate with a global team to produce actionable intelligence and represent expertise i...
Reposted 6 days ago
$128K - $187K *
Create robust machine learning systems to transform satellite imagery into reliable data. Collaborate with experts to design scalable solutions, build data pipelines, and develop models that enhance g...
3 weeks ago
Software Engineer II, Engineering
$125K - $145K *
Lead the charge in building impactful software features that enhance educators' management of English Learner programs, taking ownership from design to operation in a full-stack environment utilizing...
Reposted 2 weeks ago
$165K - $243K *
Lead the charge in data engineering excellence by mentoring a team, driving pipeline delivery, and translating stakeholder needs into actionable technical plans while ensuring operational accountabili...
Reposted today
Senior Manager, Insights, Amazon Focus
$105K - $125K *
Join as a hands-on analytics specialist, leveraging Amazon data to drive insights and support decision-making for clients. Collaborate with teams to optimize performance and enhance reporting across v...
Today
$100K - $120K *
Join us to drive impactful data analysis that enhances product performance and operational effectiveness. Collaborate with cross-functional teams to uncover insights, develop KPIs, and translate compl...
3 weeks ago
Senior Director, Client Operations
$192K - $266K *
Drive best-in-class travel support through strategic leadership and operational excellence. Oversee lodging, flights, and customer advocacy, fostering a culture of continuous improvement and exception...
Reposted 2 weeks ago
Manager, Market Intelligence & Commercial Analytics
$110K - $130K *
Lead the charge in market intelligence and sales support, bridging teams to drive insights and strategies in U.S. power markets. Collaborate cross-functionally to identify opportunities and enhance cu...
2 weeks ago
Engineering Manager, Knowledge Graph Platform
$217K - $303K *
Innovate with us to lead a high-performing engineering team, shaping a scalable AI-powered knowledge graph platform that enhances data quality and drives impactful user experiences across multiple app...
3 weeks ago
Engineering Manager, Systems Reliability Engineering
$130K - $155K *
Join a team that's redefining retail technology by leading a high-performing engineering group focused on modernizing and automating store platforms for a global audience, ensuring reliability and sca...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.