Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Software Sales Associate Director - Marketing Analytics Software
$163K - $369K *
Lead the charge in driving software sales by managing complex enterprise cycles, engaging C-suite clients, and coordinating a sales team to achieve revenue targets while fostering partnerships and opt...
Yesterday
ED, Advance Analytics and Precision Health
$225K - $418K *
Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...
1 week ago
Senior Software Engineer - Data Focused
$130K - $140K *
Contribute to the development of a modern platform by building features, connecting systems, and improving data usability. Engage with stakeholders and troubleshoot to deliver reliable software as par...
Reposted today
$95K - $115K *
Engage as a Data Visualization Engineer to design and develop advanced Power BI solutions, leveraging AI for enhanced analytics and user experiences. Collaborate with stakeholders to transform complex...
Reposted today
$115K - $130K *
Join a dynamic team as you provide essential IT support to a distributed workforce. Leverage your troubleshooting skills to resolve technical issues, enhance user experience, and contribute to a colla...
Reposted 1 week ago
Principal Software Engineer, Agentic Data Platform
$255K - $290K *
Drive the technical vision for a complex database platform, ensuring scalability and performance. Lead architecture decisions, mentor engineers, and collaborate across teams to enhance data infrastruc...
2 weeks ago
Senior AI Engineer with RAG and Agentic architectures
$138K - $165K *
Champion the development of LLM-powered applications and agentic systems. Drive complex use cases from ambiguous problems to production, ensuring high-quality and scalable AI solutions that address us...
Reposted 4 days ago
Translational AI Scientist/Engineer
$150K - $185K *
Unlock potential by designing and deploying AI systems that enhance translational science, enabling evidence-based recommendations for drug discovery and target validation through innovative technolog...
3 weeks ago
Senior Data Analyst, Enterprise
$122K - $171K *
Unlock potential by driving data-driven insights for Customer Success. Collaborate across teams to enhance customer journeys, optimize growth strategies, and shape analytics foundations that support A...
Reposted today
$170K - $190K *
Shape the future of data engineering by leading architectural improvements, enhancing data quality, and driving technical initiatives across diverse business domains. Collaborate with stakeholders to...
5 days ago
$155K - $258K *
Shape the future of AI in healthcare by leading architectural design and technical strategy for LLM-powered systems. Mentor engineers, ensure compliance, and drive innovation in a highly regulated env...
1 week ago
$118K - $147K *
Drive successful project delivery by implementing cutting-edge AI/ML solutions on Google Cloud. Collaborate with cross-functional teams to develop strategies, conduct client discovery, and provide tec...
Reposted 3 days ago
Associate Client Partner - Data & Analytics
$100K - $187K *
Engage clients as a trusted advisor, develop and execute strategic account plans, and drive business growth through effective relationship management in data and analytics services...
Reposted 3 weeks ago
$153K - $210K *
Strategize and enhance data integrity across extensive systems, ensuring all operational data is accurate and reliable for key clinical and financial workflows while enabling self-serve analytics for...
Reposted 1 week ago
Environmental Policy & Compliance Analyst
$100K - $150K *
Lead the charge in environmental policy analysis and compliance, ensuring adherence to NEPA and other regulations. Collaborate with agencies, conduct research, and draft reports to support sustainable...
1 week ago
Data Engineer in St. Louis, MO
$114K - $221K *
Lead the charge in designing and implementing efficient data pipelines, ensuring data quality and integrity during cloud migration. Collaborate within Agile teams to optimize data processes and suppor...
Today
Data Center Power Generation and Microgrids Engineer
$320K - $405K *
Innovate the future of data center power generation and microgrids. Own the architecture for on-site generation and storage systems, ensuring reliable energy solutions that meet demanding load profile...
4 days ago
Associate Director - AEP Business Analyst (MarTech)
$75K - $180K *
Join a team that's shaping the future of marketing technology strategy. Drive enterprise-level initiatives across CDP, CRM, and analytics, translating business goals into actionable plans while collab...
Reposted 5 days ago
$173K - $245K *
Unlock insights through data analytics and experimentation to enhance credit risk management. Collaborate with cross-functional teams to optimize policies, monitor performance, and drive strategic gro...
4 weeks ago
Senior Analyst, Fraud Intelligence
$125K - $145K *
Analyze and uncover fraud patterns using large-scale data to enhance protection strategies. Collaborate with cross-functional teams to develop insights and solutions that directly impact fraud prevent...
2 weeks ago
$81K *
Manage and enhance public health technology platforms, ensuring secure, reliable operations for local, state, and federal agencies. Collaborate with cross-functional teams to optimize system performan...
2 weeks ago
Data Engineer - AWS / Snowflake
$110K - $130K *
Join a dynamic team to design and implement scalable data pipelines using AWS and Snowflake. Collaborate with clients to transform data workflows and deliver high-quality solutions that drive business...
Today
Analytic Compliance, Audit Analyst II
$70K - $110K *
Unlock your potential by analyzing data and conducting audits to enhance compliance for innovative B2B and B2C platforms. Collaborate with cross-functional teams, apply critical thinking, and gain ins...
Reposted 5 days ago
Marketing Manager – Client Data & Insights
$84K - $126K *
Transform client engagement through data-driven insights and innovative CRM solutions. Lead a dynamic team to enhance client intelligence, streamline processes, and drive strategic marketing initiativ...
2 weeks ago
$153K - $219K *
Innovate data science solutions to enhance global recognition programs, streamline workflows, and ensure data integrity. Collaborate with stakeholders to translate complex requirements into reliable...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.