Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$180K - $225K *

Join a team that's redefining AI in auto claims by building and evaluating machine learning models. You'll drive product decisions through data insights, collaborating with experts to enhance claims p...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Optimize machine learning solutions by leveraging traditional algorithms and financial data. Collaborate with clients to enhance product delivery and integrate seamlessly into teams, driving impactful...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Innovate by leveraging your expertise in traditional machine learning to design and optimize solutions for diverse clients. Collaborate with teams or build products, driving impactful results in finan...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Lead the charge in developing innovative machine learning solutions, collaborating with clients to enhance their data-driven decision-making. Utilize your expertise in traditional ML algorithms to del...

Jefferson City, MORemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Analyze and manage healthcare data, optimizing pipelines and reporting. Collaborate with stakeholders to turn data into actionable insights. Embrace growth in a dynamic environment, taking ownership o...

Earth City, MORemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Engineer scalable Azure data solutions, leading architecture and modernization initiatives. Collaborate with teams to define standards and ensure high-performance data integration, governance, and sec...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$128K - $170K *

Engineer robust pipelines to transform raw conversation data into structured customer memory, ensuring accuracy and efficiency in retrieval systems while collaborating with cross-functional teams to e...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Transportation

$194K - $361K *

Reimagine your career by leading advanced analytics initiatives that drive enterprise performance. Collaborate across functions to translate insights into strategic actions, enhancing growth and marke...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$207K - $244K *

Elevate pricing strategies as you lead experimentation efforts, collaborate with cross-functional teams, and deliver actionable insights to enhance decision-making and drive business growth through da...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$300K - $350K *

Engage in a dynamic sales role, driving the full cycle from pipeline generation to closing six-figure deals in mid-market and enterprise cybersecurity. Contribute to go-to-market strategies and build...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $159K *

Lead the charge in transforming audience intelligence through innovative product strategies, enhancing consumer insights and data-driven solutions for brands and partners while ensuring privacy and co...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$166K - $230K *

Innovate and enhance the machine learning infrastructure to empower rapid model deployment and automation. Collaborate across teams to streamline operations and drive impactful solutions in ML and fin...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$106K - $152K *

Accelerate progress at the forefront of machine learning engineering, collaborating with cross-functional teams to develop and deploy innovative solutions that drive data-driven insights for millions...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Consumer Technology

$223K - $317K *

Drive the evolution of a robust Fulfillment platform, shaping architecture and strategy while mentoring teams. Lead modernization efforts to enhance scalability, reliability, and performance, ensuring...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$92K - $126K *

Drive innovative solutions by blending product analytics and low-code development, collaborating cross-functionally to enhance AI Agent capabilities and optimize Revenue Cycle operations within the he...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $108K *

Analyze and optimize enterprise data workflows, ensuring stakeholders access accurate data. Collaborate on analytics development, support data transformation in Microsoft Fabric, and enhance reporting...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$103K - $121K *

Champion project success by building pacing trackers and forecasting models, collaborating with Finance to enhance capacity planning and resource allocation, while providing leadership with real-time...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$83K - $133K *

Lead customer engagement and technical design for critical power projects, ensuring quality and compliance. Collaborate across teams to resolve issues and manage multiple projects, driving successful...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$171K - $257K *

Empower the future of Analytics & AI by leading technical sales initiatives, guiding teams, and driving customer engagement. Collaborate cross-functionally to enhance solutions and enablement, ensurin...

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Unlock your potential as a Senior Applied AI Engineer, leading teams to design and deliver impactful AI solutions. Drive technical excellence and mentor engineers while shaping the future of AI system...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Shape the future of digital transformation by leading a dynamic team to deliver innovative solutions that enhance business efficiency and customer experience across multi-functional AWS programs...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$177K - $212K *

Develop and deploy advanced ML models for multi-object tracking, ensuring robust performance in autonomous vehicles. Collaborate with cross-functional teams to enhance tracking algorithms and improve...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$225K - $265K *

Lead and mentor a diverse team of backend engineers in EDR remediation, transforming insights into actionable product capabilities while managing scope and fostering collaboration across engineering t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Partner with us to lead a dynamic model audit team, enhancing financial modelling processes while driving strategic growth and innovation across projects, all while fostering a collaborative and high...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $300K *

Lead complex analytical initiatives by developing data solutions and dashboards that drive business insights. Collaborate with stakeholders to translate requirements into scalable analytical framework...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.