Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Machine Learning (ML) Engineer (CCC Casualty / Claims Intelligence)
$180K - $225K *
Join a team that's redefining AI in auto claims by building and evaluating machine learning models. You'll drive product decisions through data insights, collaborating with experts to enhance claims p...
Today
Senior Machine Learning Engineer (Traditional ML & Financial Data) - Remote - USA
$125K - $150K *
Optimize machine learning solutions by leveraging traditional algorithms and financial data. Collaborate with clients to enhance product delivery and integrate seamlessly into teams, driving impactful...
Reposted today
Senior Machine Learning Engineer (Traditional ML & Financial Data) - Remote - USA
$125K - $150K *
Innovate by leveraging your expertise in traditional machine learning to design and optimize solutions for diverse clients. Collaborate with teams or build products, driving impactful results in finan...
Reposted yesterday
Senior Machine Learning Engineer (Traditional ML & Financial Data) - Remote - USA
$125K - $150K *
Lead the charge in developing innovative machine learning solutions, collaborating with clients to enhance their data-driven decision-making. Utilize your expertise in traditional ML algorithms to del...
Reposted 2 weeks ago
Senior Data Analyst - Archimedes
$95K - $115K *
Analyze and manage healthcare data, optimizing pipelines and reporting. Collaborate with stakeholders to turn data into actionable insights. Embrace growth in a dynamic environment, taking ownership o...
Reposted 4 weeks ago
$125K - $150K *
Engineer scalable Azure data solutions, leading architecture and modernization initiatives. Collaborate with teams to define standards and ensure high-performance data integration, governance, and sec...
2 weeks ago
$128K - $170K *
Engineer robust pipelines to transform raw conversation data into structured customer memory, ensuring accuracy and efficiency in retrieval systems while collaborating with cross-functional teams to e...
6 days ago
Director, Advanced Analytics and Modeling - Key Drivers & Actions (KDA)
$194K - $361K *
Reimagine your career by leading advanced analytics initiatives that drive enterprise performance. Collaborate across functions to translate insights into strategic actions, enhancing growth and marke...
4 days ago
Staff Applied Data Scientist, Pricing
$207K - $244K *
Elevate pricing strategies as you lead experimentation efforts, collaborate with cross-functional teams, and deliver actionable insights to enhance decision-making and drive business growth through da...
Reposted yesterday
$300K - $350K *
Engage in a dynamic sales role, driving the full cycle from pipeline generation to closing six-figure deals in mid-market and enterprise cybersecurity. Contribute to go-to-market strategies and build...
6 days ago
Director, Audience Intelligence Products| US: Remote
$150K - $159K *
Lead the charge in transforming audience intelligence through innovative product strategies, enhancing consumer insights and data-driven solutions for brands and partners while ensuring privacy and co...
6 days ago
Senior Software Engineer - Machine Learning Platform
$166K - $230K *
Innovate and enhance the machine learning infrastructure to empower rapid model deployment and automation. Collaborate across teams to streamline operations and drive impactful solutions in ML and fin...
Reposted today
Associate Machine Learning Engineer
$106K - $152K *
Accelerate progress at the forefront of machine learning engineering, collaborating with cross-functional teams to develop and deploy innovative solutions that drive data-driven insights for millions...
Today
Principal Engineer, Monetization Engineering
$223K - $317K *
Drive the evolution of a robust Fulfillment platform, shaping architecture and strategy while mentoring teams. Lead modernization efforts to enhance scalability, reliability, and performance, ensuring...
2 weeks ago
$92K - $126K *
Drive innovative solutions by blending product analytics and low-code development, collaborating cross-functionally to enhance AI Agent capabilities and optimize Revenue Cycle operations within the he...
Reposted 1 week ago
$90K - $108K *
Analyze and optimize enterprise data workflows, ensuring stakeholders access accurate data. Collaborate on analytics development, support data transformation in Microsoft Fabric, and enhance reporting...
1 week ago
Risk Adjustment Operations Senior Project Analyst
$103K - $121K *
Champion project success by building pacing trackers and forecasting models, collaborating with Finance to enhance capacity planning and resource allocation, while providing leadership with real-time...
1 week ago
$83K - $133K *
Lead customer engagement and technical design for critical power projects, ensuring quality and compliance. Collaborate across teams to resolve issues and manage multiple projects, driving successful...
2 weeks ago
Consulting Field Solutions Architect - AI/Analytics - Central Enterprise
$171K - $257K *
Empower the future of Analytics & AI by leading technical sales initiatives, guiding teams, and driving customer engagement. Collaborate cross-functionally to enhance solutions and enablement, ensurin...
3 weeks ago
$150K - $180K *
Unlock your potential as a Senior Applied AI Engineer, leading teams to design and deliver impactful AI solutions. Drive technical excellence and mentor engineers while shaping the future of AI system...
5 days ago
$120K - $145K *
Shape the future of digital transformation by leading a dynamic team to deliver innovative solutions that enhance business efficiency and customer experience across multi-functional AWS programs...
1 week ago
Senior, ML Engineer - Tracking
$177K - $212K *
Develop and deploy advanced ML models for multi-object tracking, ensuring robust performance in autonomous vehicles. Collaborate with cross-functional teams to enhance tracking algorithms and improve...
3 weeks ago
$225K - $265K *
Lead and mentor a diverse team of backend engineers in EDR remediation, transforming insights into actionable product capabilities while managing scope and fostering collaboration across engineering t...
1 week ago
Director- Model Audit, Build and Transaction Advisory
$150K - $180K *
Partner with us to lead a dynamic model audit team, enhancing financial modelling processes while driving strategic growth and innovation across projects, all while fostering a collaborative and high...
Reposted 2 days ago
$100K - $300K *
Lead complex analytical initiatives by developing data solutions and dashboards that drive business insights. Collaborate with stakeholders to translate requirements into scalable analytical framework...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.