Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$207K - $218K *

Champion innovative machine learning solutions to enhance service availability, optimize routing, and improve fulfillment efficiency in a complex logistics environment, driving profitability and shopp...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$155K - $165K *

Develop a cutting-edge data ecosystem as a Senior Data Engineer, enhancing analytics, reporting, and machine learning. Collaborate with cross-functional teams to create efficient pipelines and accessi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$150K - $180K *

Lead the charge in delivering advanced AI-powered solutions using Python. Collaborate with cross-functional teams to tackle complex challenges and drive innovation in Generative AI across diverse proj...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $250K *

Accelerate progress at the forefront of AI technology by building and operating a secure, production-grade platform. Collaborate with business teams to transform AI capabilities into measurable value...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$114K - $145K *

Unlock your potential as a Data Engineer, transforming raw data into impactful systems. Collaborate with stakeholders, optimize data architecture, and drive efficiency through automation while managin...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$122K - $213K *

Transform data solutions by designing and optimizing scalable pipelines that empower analytics and decision-making across the organization. Collaborate with stakeholders to deliver high-performance da...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$87K - $135K *

Unlock your potential by leading a dynamic Knowledge Management program that enhances IT support services, fosters collaboration, and drives efficiency for a large-scale enterprise environment. Make a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$88K - $105K *

Empower data-driven decisions by developing and maintaining robust data infrastructure. Collaborate with cross-functional teams to ensure data integrity, security, and accessibility, while driving inn...

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$173K - $182K *

Lead the charge in designing and deploying impactful machine learning systems. Collaborate across teams to drive innovation and improve business outcomes in a fast-paced environment, leveraging your e...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$140K - $190K *

Join a team that's transforming clinical trials through advanced data science. Drive the development of predictive models and machine learning algorithms to enhance patient enrollment and trial manage...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $185K *

Lead client engagements in Real-World Data solutions, ensuring operational excellence and strong outcomes. Collaborate cross-functionally to translate client objectives into actionable plans, driving...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Transform customer data integration strategies by leveraging your expertise to guide clients in optimizing data flow into the Fusion platform, ensuring reliability and value across complex environment...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$87K - $135K *

Drive your career forward by leading systems engineering for a cloud-based enterprise system. Engage in architecture development, integration, and modernization efforts while ensuring security and ope...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$200K - $235K *

Transform AI/ML systems by leading end-to-end development of innovative solutions. Tackle complex challenges in medical synthesis and help define and deploy advanced features that enhance user experie...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Business Services

$107K - $195K *

Optimize data architecture to support generative AI applications, enabling robust analysis of diverse datasets. Collaborate with teams to design, implement, and document data foundations, ensuring sea...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Technical Services

$120K - $160K *

Champion the design and implementation of scalable data pipelines, ensuring data integrity and availability. Collaborate with cross-functional teams to optimize data workflows and enhance infrastructu...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Unlock innovative AI/ML solutions by collaborating with cross-functional teams, conducting research, and deploying production-grade microservices. Drive impactful projects with ownership and contribut...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $160K *

Analyze complex operational data to drive insights and improve customer outcomes. Collaborate with cross-functional teams, lead impactful analyses, and create self-service analytics tools to enhance d...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$252K - $300K *

Unlock potential by leading the technical strategy for Data Labs, guiding engineering teams to innovate AI training solutions, and shaping the future of model evaluation and deployment in a rapidly ev...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Empower our privacy program by automating processes, managing data subject requests, and ensuring compliance with GDPR and CCPA. You'll leverage technical skills to build scalable tools and systems, d...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Transform healthcare data solutions by designing scalable architectures, optimizing data pipelines, and ensuring compliance with regulations. Collaborate with cross-functional teams to deliver high-qu...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$94K - $293K *

Join a team that's redefining data architecture by leading scalable, governed solutions. Leverage your expertise to guide engineering best practices and ensure high-quality data management across ente...

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$95K - $110K *

Drive impactful insights by analyzing real-world data in the life sciences sector. Collaborate with cross-functional teams to enhance patient care and support evidence-based decision-making through in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$92K - $110K *

Join a team that’s dedicated to creating robust data solutions, enhancing data pipelines, and driving efficiency across multiple systems. Collaborate with various teams to leverage data for impactful...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$128K - $165K *

Empower Fraud Operations by leading AI-driven automation initiatives, enhancing investigative workflows, and delivering actionable insights to optimize fraud detection and prevention efforts across th...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.