Senior Scientist - Bioanalytical Method Development LC-MS/MSThe Senior Method Development Scientist will perform method development utilizing contemporary mass spectrometry techniques (LC-MS/MS & HRMS) for large and small molecules (proteins, antibodies, ADCs oligonucleotides, etc.). The senior method development scientist will be a member of the DMPK team and will serve as a subject matter expert for new proposals, evaluating feasibility of LC-MS/MS method development, and troubleshooting challenging methods across a wide variety of species and matrices.
Essential Duties and Responsibilities- Develop highly sensitive LC-MS/MS and HRMS methods for large (oligonucleotides, proteins, antibodies, ADCs, biomarkers, etc) and small molecules in biological matrices.
- Utilize and interpret scientific theories, concepts, techniques in bioanalytical and mass spectrometry studies and accepts leadership role in developing novel scientific approaches
- Coordinate, facilitate, and implement intercompany method transfers and implementation of incoming transfers from clients.
- Communicate project timelines, status, and data to Principal Investigators, Project Management, and clients effectively addressing any issues that may arise.
- Ability to coordinate and execute on multiple projects simultaneously and responsive to unscheduled deadlines and client needs.
- Demonstrate an understanding of Best Practices, SOPs and Good Laboratory Practice Regulations (21 CFR, Part 58) as these relate to study-specific services provided, this job description, and general facility operations.
- Training and mentoring junior scientists within and across departments
- Collaborate with leadership on long-range planning and strategy for departmental growth
- Performs other duties as assigned.
Skills and Abilities- Experience, skills, and abilities must include knowledge of contemporary bioanalytical techniques, including wet chemistry separations, liquid chromatography, and mass spectrometric analysis (LC-MS/MS, HRMS), instrument operation, maintenance, and data processing.
- Proven track record of method development for large and small molecules
- Ability to incorporate software in the maintenance of databases to collate and catalog records and inventory.
- Working knowledge of laboratory software, system software, and Microsoft applications
- Independence in the laboratory and data work-up phases of research.
- A working knowledge and awareness of general laboratory procedures.
- Good written and oral communication skills.
- Ability to adhere to all safety regulations and procedures.
Education and Experience- PhD in Organic Chemistry, Biochemistry, Analytical Chemistry or related discipline with 2+ years of industrial bioanalytical experience following Post Doctoral training
- M.Sc. in a discipline previously described with 5+ years direct industrial bioanalytical experience
- Candidates possessing working knowledge of in vitro metabolism/biotransformation, Pharmacokinetic modeling, analysis, interpretation and simulation desirable
Physical Activity and Working Conditions- Work is normally performed in a typical interior office work or laboratory environment
- Work environment involves exposure to potentially dangerous materials and situations that require following extensive safety precautions and may include use of protective equipment
- The noise level is usually moderate
- This position will frequently be involved with radiant/electrical energy, solvents, grease, oil, irritants, acids, bases, and other hazardous chemicals, electro-mechanical hazards, flammable materials and bio-hazards. Due to exposure to hazardous biological material (which may include HIV positive specimens), immunization to Hepatitis B and/or other diseases may be a requirement.
Salary will be commensurate with experience and responsibilities. Benefits include health and dental coverage, short- and long-term disability, paid time off, paid parental leave, 401K participation with company match, and more!
*This position could be offered at different levels for candidates who qualify with a combination of advanced levels of education and/or years of experience. The salary range will adjust along with the level of the role to match the person's relevant experience and/or education level.
Salary will be commensurate with experience and responsibilities. Benefits include health and dental coverage, short- and long-term disability, paid time off, paid parental leave, 401K, and more!
