Job Description
Job Title: Senior Scientist– Assay Development in Neuroscience Biomarker Discovery
Location: Boston, MA (On-Site)
Reporting to the Neuroscience Biomarker discovery lead at our company, this individual will play a pivotal role in assay development and generating data in support of biomarker strategies from preclinical models to human clinical and observational studies for Alzheimer's disease (AD), Parkinson's disease (PD) and Pain.
This is a lab-based position located in Boston. You will lead the design, development, optimization, and automation of complex, high-dimensional assays to process human biofluids and tissues, generating the robust datasets required for pipeline Go/No-Go decisions and patient stratification.
Primary Responsibilities:
Plan, design, execute and deliver high-quality biomarker datasets from observational human and preclinical samples in support of pipeline programs in Neuroscience at our company.
Serve as a subject matter expert and lead the design, development, and qualification of fit-for-purpose biomarker methods. This includes driving our workhorse ultra-sensitive immunoassays while spearheading the adoption of high-plex NGS-based proteomic platforms (e.g., Olink).
Partner closely with data scientists within and outside the team to ensure automated workflows yield high-fidelity data suitable for mixed-effects modeling and multi-omics integration. Collaborate with Mechanistic Validation scientists to support in vitro, in vivo readouts.
Work on-site in the lab and summarize data and status of results with internal and external partners.
Participate and contribute to the generation of data packages that enable key governance decisions for pipeline programs.
Take the lead in identifying, piloting, and automating novel high-throughput methodologies for biomarker discovery (e.g., implementing robotic liquid handling, flow-cytometry based immune-cell profiling using single cell sequencing in human and mouse samples, or extracellular vesicles).
Required Qualifications:
Master’s in molecular biology, Biochemistry, Neuroscience, Immunology, Neurology, or related STEM fields with minimum 6 years of relevant industry experience OR PhD in molecular biology, Biochemistry, Neuroscience, Immunology, Neurology, or related STEM fields with hands-on relevant experience.
Demonstrated expertise in biomarker assay development and implementation in large scale human cohorts and samples from in vivo/in vitro studies.
Extensive, hands-on expertise in developing de novo ultra-sensitive, multiplexed immunoassays (e.g. O-link), coupled with direct practical experience in Next-Generation Sequencing (NGS) workflows.
Proven hands-on expertise in programming and implementing laboratory automation tools and liquid handlers to scale high-throughput immunoassay and/or NGS-based datasets generation.
Excellent oral and written communication skills and thrive in a highly collaborative and cross-functional environment.
Demonstrated experience with clinical assay validation parameters (accuracy, precision, reproducibility) and regulatory guidelines (FDA/ICH) for biomarker qualification.
Desired Qualifications:
Prior experience working in the Neuroscience therapeutic area, particularly in Neurodegeneration (eg. AD or PD).
Prior expertise in implementing end-to-end NGS based workflows using the Illumina platform.
Experience in one or more of the following techniques (flow cytometry panel design and data analysis, analysis of extracellular vesicles, NGS workflows, single-cell RNA sequencing).
Adept at or strong willingness to leverage AI tools for conducting data quality controls and sound statistical analysis of large-scale datasets.
#EligibleforERP
Required Skills:
Assay Development, Bioassay Development, Biomarker Development, Biomarker Discovery, Biomarker Identification, Biomarkers, Disease Models, Drug Discovery Research, Flow Cytometry, High-Throughput Screening, Immunoassays, In Vitro Assays, In Vivo Models, Molecular Biology Techniques, Neurodegeneration, Next Generation Sequencing (NGS), Omics, Preclinical Research, Protein Purifications, RNA-Seq, Scientific Writing
Preferred Skills:
Current Employees apply
Current Contingent Workers apply
US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please if you need an accommodation during the application or hiring process.
The salary range for this role is
$106,200.00 - $167,200.00
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at .
You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic
VISA Sponsorship:
Yes
Travel Requirements:
10%
Flexible Work Arrangements:
Not Applicable
Shift:
Not Indicated
Valid Driving License:
No
Hazardous Material(s):
BSL2, OEB4, Bloodborne pathogens
Job Posting End Date:
09/21/2026
*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
