Senior Technical Operations Manager

Rapport Therapeutics

$175K — $195K *
Pharmaceuticals & Biotech
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's degree in life sciences, engineering, or related field
  • 5+ years in CMC operations or logistics within biotech/pharma
  • Managed complex logistics including vendor coordination and inventory
  • Highly organized with strong attention to detail
  • Experience with CDMOs and CROs in a GMP/GxP environment
  • Exceptional project management and communication skills
  • Proficient in Microsoft Office and project management tools

Responsibilities

  • Coordinate cross-functional program execution across CMC, Quality, Supply Chain, and Toxicology
  • Maintain integrated development plans and timelines
  • Track milestones, risks, action items, and support communications
  • Coordinate logistics for materials and clinical supplies
  • Ensure operational readiness for regulatory milestones
  • Oversee CDMO and CRO activities for timely deliverables
  • Partner with Finance to monitor expenses and vendor performance

Benefits

  • Unlimited PTO
  • Lifestyle spending account
  • Commuting reimbursement
  • Collaborative and innovative work environment
  • Strong emphasis on personal and professional growth
  • Encouraging team culture that values diverse perspectives
Full Job Description
This role is based in Boston, MA with onsite presence required Monday-Wednesday

Your impact:

The Senior Technical Operations Manager plays a critical role in driving cross-functional execution across CMC (Chemistry, Manufacturing & Controls), Supply Chain, Quality, and Toxicology to advance small molecule programs from early development through late-stage clinical development and NDA submission.

This role combines program management with operational logistics, ensuring alignment of timelines, deliverables, and resources across internal teams and external partners. The ideal candidate will bring strong CMC program management expertise, operational rigor, and the ability to proactively identify and mitigate risks across drug substance and drug product development activities, including outsourced manufacturing and nonclinical support.

Your day-to-day:

Program Operations & Logistics
  • Coordinate cross-functional program execution across CMC, Quality, Supply Chain, and Toxicology
  • Maintain integrated development plans, timelines, and program documentation
  • Track key milestones, risks, action items, and support program communications
  • Coordinate logistics for raw materials, API, drug product, and clinical/nonclinical supplies, including inventory, shipments, and documentation
  • Ensure operational readiness to support regulatory milestones and development activities

Vendor & Supply Chain Management
  • Coordinate CDMO and CRO activities to support program timelines and deliverables
  • Support SOW execution, vendor performance tracking, and budget management
  • Partner with Finance and functional teams to monitor program expenditures
  • Collaborate with Quality to ensure compliant material handling, distribution, and supply continuity

Must-Haves:
  • Bachelor's degree in a life sciences, engineering, supply chain, or related field
  • 5+ years of experience in CMC operations, supply chain, logistics, or project management within the biotechnology or pharmaceutical industry.
  • Demonstrated experience managing complex logistics, including material planning, inventory, vendor coordination, and time-sensitive shipments.
  • Highly organized with exceptional attention to detail and the ability to manage multiple priorities across cross-functional teams.
  • Experience working with CDMOs, CROs, and external vendors in a regulated GMP/GxP environment.
  • Strong project management and communication skills with a proven ability to track timelines, risks, budgets, and deliverables.
  • Proficiency with Microsoft Office (Excel, PowerPoint, Project) and document management/project tracking systems.
  • Ability to work independently in a fast-paced, dynamic environment while maintaining a high level of accuracy and accountability.

What makes Rapport special:
  • Every role has meaning. We're determined to discover a better way for patients, and you'll feel the passion from the start.
  • We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities.
  • Your perspective matters. Stick your neck out, share your ideas - we work as a team.
  • We have FUN. We hire smart, dedicated, down-to-earth people that you'll enjoy spending time with.
  • Leadership that CARES - about you, your growth + development.
  • We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston - we make the most of our time together.
  • Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more!
  • You get to be YOU! Show up as you are and make every day count.

Your Compensation:

We get it. Compensation is an important part of your offer. You shouldn't be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this? We tell you about our hiring range now - we expect the hiring range for the role to be $175,000 to $195,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don't stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company.

Hybrid Work Environment:

We prioritize in person connection with our fellow Rapptors! Our team members come together onsite at our Boston office Monday-Wednesday to create more opportunities for innovation, collaboration, and connection.

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