Job Function: Discovery & Pre-Clinical/Clinical Development
Job Sub Function: Biological Research
Job Category:Scientific/Technology
All Job Posting Locations:Spring House, Pennsylvania, United States of America
Job Description:Johnson & Johnson (J&J) is recruiting for a
Senior Scientist, Neuroscience Discovery to join our Neuroscience Discovery group based in Springhouse, PA, USA.
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Our Neuroscience team tackles the world's toughest brain health challenges including multiple sclerosis, Alzheimer's disease, Parkinson's disease, myasthenia gravis, epilepsy, major depressive disorder, bipolar disorder, schizophrenia, and autism. This patient-focused team helps address some of the most complex diseases of our time.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at https://www.jnj.com/innovative-medicine
You will be applying cutting-edge science and developing translational cellular platforms e.g., complex iPSC cellular models of disease and high content imaging, to identify novel targets and validate them sufficiently to enter the Neuroscience Discovery Portfolio. You will work closely with our Data Science colleagues to leverage large data sets e.g. proteomics and transcriptomics, as well as genetic and real-world evidence data to shape the discovery portfolio. Your work will be instrumental for us to continue building a transformational Neuroscience portfolio to develop novel treatments for Neurodegenerative, Neuropsychiatric and Retinal Diseases, with an emphasis on neuroimmune biology. This will require excellent communication and teamwork skills, an appetite for innovation, and a keen attention to detail and organization. You should have a considerable sense of purpose and drive, be mindful of the considerable unmet medical need and imperative to generate impactful therapeutics in Neuroscience, and embody the critical importance of translation of insights from biology and data science to the vision and mission of Johnson & Johnson.
Your Key Responsibilities:- Developing complex human cell models of neurological disorders to identify and validate novel druggable targets with the emphasis on neuroimmune aspects of a disease.
- Collaborating closely within the Global Biology function and with other functions, including but not limited to, Data Sciences, Discovery Technology & Molecular Pharmacology and In Silico Discovery to integrate data from human cell models, human omics data, and other datasets coupled to AI and machine learning.
- Effective oral and written communication to ensure alignment across functions and within the neuroscience department.
Required:- A PhD degree in Neuroscience or related biological research discipline (such as cellular biology or biochemistry).
- Strong knowledge in cell and molecular biology, and iPSC modeling of neuroimmune biology and microglia.
- Demonstrated experience working with human cell models to develop a platform to explore disease pathways and validate novel targets.
- Strong skills in biochemical assays and cell imaging.
- Ability to independently conduct and interpret complex biological experiments, self-motivated to learn and develop new techniques, keep accurate records, and comply with company policies.
- Ability to work in teams, and develop and maintain strong internal network.
- A proven track record of evaluation of novel cell mechanism in Neuroscience or related biological field, that is reflected in publications in peer reviewed journals.
- Proactively creates a purpose driven environment by aligning Johnson & Johnson's Credo and Leadership Imperatives with the strategies and goals of the team and enterprise.
- Broadens external scientific visibility and reputation of J&J by publications and participating in scientific seminars and discussion forums.
- Crafts presentations of research outcomes and progress to senior leaders by owning the analysis of results and providing critical feedback.
Preferred:- Experience in running the high-throughput assays and analysis of large data sets.
- Experience working in drug discovery environment.
Required Skills: Preferred Skills: 
