Company DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.
Job DescriptionAbbVie Analytical Research & Development (Analytical R&D) is a global analytical scientific organization responsible for all CMC analytical activities related to the development of AbbVie's pharmaceutical products. Our scope includes AbbVie's diverse pipeline of innovative small molecule and therapeutic biologic medicines and spans from the selection of Discovery candidate molecules to Late Stage Clinical. We are building a world-class team of scientists and leaders who will drive the advancement of industry-leading analytical capabilities and make meaningful contributions to advance AbbVie's pipeline of innovative medicines. Careers in AbbVie Analytical R&D provide unique opportunities to work with global and cross-functional teams to drive exceptional science and innovative product development strategies. We are looking for diverse candidates with strong scientific experience to join the AbbVie Analytical R&D team and can offer exciting and rewarding career opportunities for these candidates.
Position Description:
For the Senior Scientist II position, we are seeking a highly motivated candidate who can conceive, implement and execute novel scientific research and development. Generate new scientific proposals and lead these efforts. Act as a lead scientist in his/her area of expertise and critically evaluate relevant scientific and regulatory advances and integrate this knowledge into research and development programs.
This position will be within Analytical R&D's Screening Lab, which functions as a high-throughput method screening and development group that serves a diverse set of stakeholders and impacts all pipeline programs. The Screening Lab is seeking a Separations Scientist with experience in chromatographic method development for small molecules and biologics. An ideal candidate would have hands-on experience developing methods and troubleshooting difficult separations related challenges. Additionally, He/she should possess an understanding of core discipline and support early phase development of New Chemical Entities (NCEs) and New Biologic Entities (NBEs) for both drug substance and drug product in preclinical and clinical programs.
An ideal candidate will have pharma related project lead experience and have a proven track record of developing novel approaches for method development and solutions for difficult separations. Additional experience with advanced CDS control, process chromatography, and automation, as well as experience with emerging drug modalities (LNPs, Peptides, Oligos, etc.) is desirable. In this dynamic and fast-paced environment, your expertise and insight will ensure that robust and reliable methods enable pipeline projects.
Responsibilities:
• Support high-throughput platform screening capabilities for separation-based assays for small-molecules and biologics (Chiral, Achiral, HILIC, SFC, 2DLC, HIC, IEX, SEC, etc.)
• Development of stability indicating methods using a variety of analytical separation (HPLC/UHPLC) and detection modes (UV, MS, CAD) for active pharmaceutical ingredients.
• Employ chromatographic modeling software (Fusion, Drylab, Chromsword, etc.) for method development and robustness.
• Apply analytical separation and detection modes for complex impurity profiling of pharmaceutical products to further the understanding of emerging cGMP manufacturing processes.
• Perform assay qualifications to establish specificity, sensitivity, linear range, precision, robustness, and accuracy of test methods.
• Responsible for leading the analytical aspects of a project while working with other functional areas to advance projects through the development pipeline from preclinical to clinical candidates.
• Utilize understanding of a range of analytical techniques to conduct research and development studies related to small-molecule active pharmaceutical ingredients, intermediates, starting materials, impurities along with pre-clinical to clinical formulations.
• Communicate and collaborate with cross-functional groups and departments.
• Expected to evaluate novel technology approaches and build scientific profile both internally and externally in terms of pipeline contributions and scholarly achievements.
• Contribute to writing of publications, presentations, and patents.
Qualifications• Bachelors, Masters, or Ph.D. in Analytical Chemistry typically with a minimum of 12 (BS), 10 (MS), or 4 (Ph.D.) years related industry experience.
• Strong technical background in analytical chemistry, excellent analytical problem-solving skills. Capable of independently developing and troubleshooting analytical methods.
• Hands on experience with HPLC analysis and method development along with expertise and fundamental understanding of spectroscopic techniques.
• Possesses a strong understanding of fundamental properties and theory of chromatography.
• Experience in the use of computerized data handling systems.
• Practical knowledge of organic structure, functional groups, chemistry, and modern spectroscopic techniques as applied to small-molecule analytical analysis.
Additional InformationApplicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
- The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
- We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
- This job is eligible to participate in our short-term incentive programs.
- This job is eligible to participate in our long-term incentive programs
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
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