AbbVie

Senior Scientist I - II, Computational HitGen / LeadGen

AbbVie • $120K — $145K *
North Chicago, IL 60064In-Person
Pharmaceuticals & Biotech
8 - 10 years of experience
Today
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Job Overview by Ladders

Qualifications

  • Degree in chemistry, computer science, machine learning, cheminformatics, or chemical engineering with relevant experience in machine learning (10+ years for BS, 8+ years for MS, 0+ years for PhD for Sr. Scientist I; 12+ years for BS, 10+ years for MS, 4+ years for PhD for Sr. Scientist II)
  • Proficient in modern computational techniques applicable to medicinal chemistry
  • Expertise in machine learning, deep learning, and cheminformatics
  • Ability to develop and maintain computational tools using programming languages, particularly Python
  • Familiarity with AI/ML molecular generation, pose prediction, and pharmacological property prediction
  • Knowledge of retrosynthetic analysis for developing novel designs
  • Demonstrated analytical and problem-solving abilities, both independently and in collaboration with teams
  • Excellent communication skills for conveying complex ideas to diverse audiences.

Responsibilities

  • Consult with project teams to define project-relevant hit/lead criteria
  • Develop proficiency with cutting-edge computational methods
  • Identify and deploy the best computational methods for specific project goals
  • Communicate rationale for chosen methodologies to project teams
  • Develop workflows for computational hit generation, including predicting binding affinities and designing compounds with desired properties
  • Evaluate synthetic tractability of AI-generated designs
  • Contribute collaboratively with medicinal chemists and other experts to advance drug discovery efforts.

Benefits

  • Comprehensive benefits package including paid time off, medical, dental, and vision insurance
  • Participation in long-term incentive programs
  • 401(k) plan to eligible employees.
Full Job Description
Job Description

Purpose:

This position brings an opportunity to make innovative contributions that will define how AbbVie leverages AI-enabled drug discovery across our small molecule portfolio. The key responsibilities of this position are to identify, develop, optimize, validate, and deploy innovative methods for computational hit generation. This role will collaborate closely with project teams comprising medicinal chemists, structural biologists, biochemists, cell biologists, and other computational chemistry / chemoinformatics experts.

Responsibilities:
  • Consult with project team to establish desirable project-relevant hit/lead criteria
  • Develop and maintain proficiency with the collection of cutting-edge computational methods available to the HGLG team
  • Support project teams by decisively identifying the method(s) that best fit the project goals, and deploying the most suitable method(s) for the task at hand
  • Effectively communicate to the project team the rationale for chosen methodologies, explaining how these approaches are optimally suited to the task and how they inform the resulting designs for a given target
  • Contribute to development of methods / workflows for computational hit generation, including methods to predict binding affinities of diverse chemotypes, to design compounds with specified pharmacological properties (PK parameters, etc.), and to rapidly sample both enumerated and AI-generated chemical spaces. Computational methods to evaluate / optimize synthetic tractability of designs from generative AI are of particular interest for this role.


Qualifications
  • Senior Scientist I: Degree in relevant field (chemistry / computer science / machine learning / cheminformatics / chemical engineering) with experience developing machine learning models related to chemical and biological data (10+ years of experience for BS, 8+ years for MS, 0+ years for PhD)
  • Senior Scientist II: Degree in relevant field (chemistry / computer science / machine learning / cheminformatics / chemical engineering) with experience developing machine learning models related to chemical and biological data (12+ years of experience for BS, 10+ years for MS, 4+ years for PhD)
  • Knowledge and experience in modern computational approaches for medicinal chemistry
  • Expertise using cutting-edge computational approaches built on Machine Learning/Deep learning and Cheminformatics
  • Ability to implement, debug, and maintain computational tools in common programming languages (e.g., Python)
  • Familiarity with AI/ML-enabled molecular generation, pose prediction, affinity prediction and/or prediction of pharmacological properties (e.g. PK)
  • Familarity with retrosynthetic analysis, to contribute to refining workflows for generation/prioritization of novel molecules on the basis of synthetic tractability
  • Strong analytical and problem-solving skills with demonstrated ability to think critically and creatively, and provide solutions both individually and collaboratively with internal experts
  • Excellent ability to communicate clearly and concisely with colleagues and collaborators including an ability to explain complex ideas to non-specialists
  • Preferred: has contributed to molecular design in an early-stage drug discovery campaign (hit gen / lead gen)


Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
  • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
  • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
  • This job is eligible to participate in our long-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.

About AbbVie

AbbVie develops pharmaceuticals and medical devices. They provide products and services to therapeutic areas including immunology, oncology, neuroscience, eye care, virology, women's health, and gastroenterology.

AbbVie Careers

Joining AbbVie means becoming part of a global team dedicated to making a remarkable impact on patients' lives. At AbbVie, our employees are united in the pursuit of groundbreaking innovation and are committed to transforming the future of healthcare with leading-edge science.

Work You’ll Do

At AbbVie, you’ll collaborate with some of the brightest minds in the industry to solve challenging problems that have a high impact on society. Our culture fosters growth and embraces leadership and diversity training, ensuring that every team member can thrive.

Explore Job Opportunities

AbbVie offers a wide range of job opportunities and career paths, providing a platform where professionals can propel their careers forward. From research and development to marketing and sales, the potential to make a significant impact is limitless.

Internship Programs

Kickstart your career with an AbbVie internship. Our programs provide invaluable industry experience and a chance to develop essential skills in a real-world setting. Interns at AbbVie are considered integral members of the team and are given tasks that are both challenging and rewarding.

Professional Growth and Development

We believe in nurturing our team's professional growth through comprehensive training programs, leadership development opportunities, and continuous learning. Our commitment to your career growth is reflected in our robust offerings that enhance your skills and knowledge.

Benefits and Culture

AbbVie is dedicated to supporting our employees' well-being both inside and outside of work. Our benefits package includes health, financial, and social benefits that are designed to support the diverse needs of our employees. Our inclusive culture encourages collaboration and innovation, fostering a workplace where all can excel.

Hiring Process

Our hiring process is designed to ensure a match that will be beneficial both for the company and for your career aspirations. From resume submission to interview, each step is an opportunity to showcase your skills and fit with the AbbVie team.

Networking and Career Advancement

At AbbVie, networking doesn’t just enhance your career; it propels it. We encourage our employees to engage internally and externally to build relationships that foster personal and professional growth.

Join Our Team

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Explore AbbVie Jobs

Whether you’re seeking to advance your career in a dynamic and empowering environment, or looking for a place where you can innovate, lead, and contribute to something bigger, AbbVie is the place for you. Join us in our mission to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow.
Learn more about AbbVie
Size
50,000 employees
Market Cap
$288.5 billion
Industry
Pharmaceuticals & Biotech
Net Income
$4.6 billion
Founded
2013
5 Year Trend
+17%
Revenue
$45.8 billion
NASDAQ
ABBV
* Ladders Estimates

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