AbbVie

Senior Scientist I

AbbVie • $100K — $130K *
Waltham, MA 02453In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
Today
Be an Early Applicant
Job Overview by Ladders

Qualifications

  • BS with 10+ years', MS with 8+ years', or PhD with 0+ years' experience in industry.
  • Degree in chemistry or chemical engineering.
  • Strong scientific communication and interpersonal skills for effective collaboration.
  • Thorough understanding of organic chemistry and reaction mechanisms.
  • Proficient with HPLC/UPLC instruments, including maintenance and troubleshooting.
  • Ability to multitask and adhere to timelines.

Responsibilities

  • Design, execute, and analyze conjugation experiments independently.
  • Perform conjugation and purification operations from mL to 10L scale reactions.
  • Conduct routine sample preparation and operate HPLC-based analytical assays.
  • Assess scale dependence of chemical reactions and purification engineering factors.
  • Document and present results using electronic lab notebooks and technical reports.
  • Master laboratory techniques to serve as a subject matter expert for junior staff.
  • Collaborate effectively within a multi-disciplinary team.

Benefits

  • Paid time off including vacation, holidays, and sick leave.
  • Comprehensive medical, dental, and vision insurance.
  • 401(k) retirement savings plan available.
  • Eligibility for short-term incentive programs.
Full Job Description
Job Description

We are looking for a motivated candidate to support late-stage process development of Antibody-Drug-Conjugates (ADCs) and other emerging conjugation modalities. Primarily, the candidate will independently design and perform conjugation experiments, perform downstream operations such as Tangential Flow Filtration (TFF) purifications, and analyze experimental and analytical results - either running analyses independently or via sample submission to Analytical Development colleagues. This late-stage development work will ultimately support process characterization, commercialization, and regulatory submissions for ADC therapies in AbbVie's development pipeline. The candidate is expected to work with managers and key stakeholders or collaborators to effectively plan and communicate experimental timelines and results. ADC development work is inherently interdisciplinary and cross-functional, so a strong candidate will be able to quickly learn and develop functional knowledge of adjacent development areas to understand how those interface with conjugation process development.

Responsibilities
  • Maintain a high degree of productivity in lab to support conjugation process development: independently design, execute, and interpret key experiments to answer scientific questions.
  • Perform conjugation and purification operations at reaction scales ranging from ~mL scale reactions up to a 10L reactor.
  • Perform routine sample preparation and operation of HPLC-based analytical assays.
  • Understand scale dependence of chemical reactions or purifications, or engineering scale factors.
  • Document and share results via electronic laboratory notebooks, internal technical presentations, and technical reports.
  • Learn, understand, and master relevant laboratory techniques, and serve as a subject matter expert and mentor for junior scientists in lab.
  • The candidate will understand and adhere to corporate standards regarding code of conduct, safety and GXP compliance.
  • Work collaboratively within a multi-disciplinary team, including analytical chemists, process chemists, and manufacturing personnel.


Qualifications
  • BS with 10+ years', MS with 8+ years', and PhD with 0+ years' industry experience.
  • Degree in chemistry or chemical engineering.
  • Strong scientific communication and interpersonal skills to drive collaboration within the conjugation process development team and with cross-functional partners.
  • Thorough understanding of organic chemistry, theoretical conceptualization of reaction mechanisms, and practical 'fluency' with wet-lab operations and running chemical reactions.
  • Extremely knowledgeable in HPLC/UPLC instruments: familiar with equipment care and maintenance best practices for shared lab equipment, ability to perform basic troubleshooting of HPLC systems.
  • Ability to multitask and meet timelines.


Preferred Qualifications
  • Prior experience with drug-conjugate chemistry or conjugation process development is not necessary but strongly preferred.
  • Advanced degree (MS or PhD) in organic chemistry, or experience in small molecule chemistry.
  • Experience in design-of-experiments (DoE), quality-by-design (QbD), and development of statistical and mathematical models


Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
  • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
  • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
  • This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.

About AbbVie

AbbVie develops pharmaceuticals and medical devices. They provide products and services to therapeutic areas including immunology, oncology, neuroscience, eye care, virology, women's health, and gastroenterology.

AbbVie Careers

Joining AbbVie means becoming part of a global team dedicated to making a remarkable impact on patients' lives. At AbbVie, our employees are united in the pursuit of groundbreaking innovation and are committed to transforming the future of healthcare with leading-edge science.

Work You’ll Do

At AbbVie, you’ll collaborate with some of the brightest minds in the industry to solve challenging problems that have a high impact on society. Our culture fosters growth and embraces leadership and diversity training, ensuring that every team member can thrive.

Explore Job Opportunities

AbbVie offers a wide range of job opportunities and career paths, providing a platform where professionals can propel their careers forward. From research and development to marketing and sales, the potential to make a significant impact is limitless.

Internship Programs

Kickstart your career with an AbbVie internship. Our programs provide invaluable industry experience and a chance to develop essential skills in a real-world setting. Interns at AbbVie are considered integral members of the team and are given tasks that are both challenging and rewarding.

Professional Growth and Development

We believe in nurturing our team's professional growth through comprehensive training programs, leadership development opportunities, and continuous learning. Our commitment to your career growth is reflected in our robust offerings that enhance your skills and knowledge.

Benefits and Culture

AbbVie is dedicated to supporting our employees' well-being both inside and outside of work. Our benefits package includes health, financial, and social benefits that are designed to support the diverse needs of our employees. Our inclusive culture encourages collaboration and innovation, fostering a workplace where all can excel.

Hiring Process

Our hiring process is designed to ensure a match that will be beneficial both for the company and for your career aspirations. From resume submission to interview, each step is an opportunity to showcase your skills and fit with the AbbVie team.

Networking and Career Advancement

At AbbVie, networking doesn’t just enhance your career; it propels it. We encourage our employees to engage internally and externally to build relationships that foster personal and professional growth.

Join Our Team

Search open positions that match your skills and interests. We are looking for passionate, curious, and innovative team players who are ready to make a difference.

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Explore AbbVie Jobs

Whether you’re seeking to advance your career in a dynamic and empowering environment, or looking for a place where you can innovate, lead, and contribute to something bigger, AbbVie is the place for you. Join us in our mission to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow.
Learn more about AbbVie
Size
50,000 employees
Market Cap
$288.5 billion
Industry
Pharmaceuticals & Biotech
Net Income
$4.6 billion
Founded
2013
5 Year Trend
+17%
Revenue
$45.8 billion
NASDAQ
ABBV
* Ladders Estimates

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