Job Function: Discovery & Pre-Clinical/Clinical Development
Job Sub Function: Biotherapeutics R&D
Job Category:Scientific/Technology
All Job Posting Locations:Spring House, Pennsylvania, United States of America
Job Description:We are searching for the best talent for a Senior Scientist, Cell Therapy Genetic Regulation to be located in Spring House, PA.
Purpose:We are seeking a motivated and high performing Senior Scientist to join the Cell and Genetic Medicines group within Therapeutics Discovery (TD) to support the development of CAR T cell therapy programs. In this role, you will be applying cutting-edge genetic regulation approaches to develop and implement gene modulation strategies that enhance the safety, efficacy, persistence, and functionality of CAR T cell therapy platforms. You will work directly with human T cells - including culture, activation, expansion, and genetic modification - to design, optimize, and deploy genetic regulation tools and screening workflows that support the discovery and advancement of next-generation cell therapy programs. The ideal candidate will combine deep technical expertise in genetic engineering with the ability to work independently in the lab and collaborate across cross-functional teams. This role is an exciting opportunity to join a diverse and ambitious discovery team and to work with innovative technology to create life-changing therapies for patients.
You will be responsible for:- Lead development of genetic regulation tools tailored for multiple cell therapy platforms.
- Design, execute, and optimize screening workflows to identify and validate gene modulation designs.
- Advance assay development and validation pipelines to ensure on-target activity, specificity, and functional effects in relevant cell therapy platforms.
- Collaborate closely with other team members and cross-functional teams to drive project milestones, produce shared data packages, and align experimental plans with program timelines.
- Stay current on the latest scientific and technological advancements in genetic regulation and cell therapy, incorporate new knowledge into ongoing projects, and propose new research directions.
- Analyze experimental data, prepare clear technical reports, and effectively communicate results to senior leadership, internal partners, and external partners as required.
- Maintain accurate and detailed experimental procedures, data, and results in an electronic laboratory notebook and ensure compliance with laboratory protocols and safety procedures.
Qualifications:Required:- PhD in Molecular Biology, Bioengineering, Genetics or a related biological research discipline.
- Minimum 2 years of post-PhD experience (biopharmaceutical or biotech experience preferred).
- Strong knowledge in genetic regulation strategies and genetic modulation technologies.
- Demonstrated experience designing, screening, and validating genetic regulation tools in a cell therapy-relevant context.
- Ability to independently perform lab-based responsibilities with limited guidance.
- Strong collaborative skills and experience coordinating experiments and data exchange across teams.
- Self-motivated, highly organized, and able to manage competing priorities in a fast-paced discovery environment.
Preferred:- Hands-on experience in molecular cloning, including the design, construction, and screening of pooled libraries for high-throughput assays.
- Experience with primary human T cell culture, expansion, and genetic engineering (viral transduction and/or non-viral gene editing).
- Experience in lentiviral vector design and optimization experience is preferred.
- Familiarity with flow cytometry, next-generation sequencing, and basic bioinformatics analyses.
Required Skills: Preferred Skills:Analytical Reasoning, Biochemistry, Chemistry, Manufacturing, and Control (CMC), Coaching, Consulting, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Pharmacogenetics, Pharmacovigilance, Process Improvements, Quality Assurance (QA), Relationship Building, Research Documents, Scientific Research, Technologically Savvy
