Regeneron Pharmaceuticals, Inc

Senior Scientist: Bispecifics and Antibody Engineering

Regeneron Pharmaceuticals, Inc$109K — $179K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • PhD in molecular biology, cell biology, biochemistry, immunology or related field
  • Minimum one year of relevant experience in academia or industry
  • Core hands-on experience with cloning and antibody expression
  • Experience with antibody purification using AKTA systems
  • Strong protein characterization skills

Responsibilities

  • Design and produce innovative multi-specific antibodies
  • Utilize molecular and structural-guided design for construct generation
  • Produce and purify novel alternative format antibodies
  • Characterize binding affinities and stability of antibodies
  • Develop high-throughput biochemical and cell-based assays
  • Troubleshoot data to enhance subsequent experimental iterations
  • Communicate biologic designs and updates to program stakeholders

Benefits

  • Opportunity to work in a fast-paced, innovative environment
  • Direct contribution to the development of next-generation therapeutics
  • Collaboration within a diverse, cross-functional team
  • Training for motivated learners in advanced antibody engineering techniques
  • Access to modern software and cutting-edge tools for research
Full Job Description

We are seeking a results-driven Senior Scientist to join Regeneron’s Antibody Engineering team within the Bispecifics and Antibody Engineering Department. In this fast-paced, innovative group, you will design, produce, and characterize next-generation antibody and protein therapeutics across multiple therapeutic areas with a focus on myeloid cell biology.  Your work will directly contribute to the pipeline and help build new platform capabilities at a pivotal time for antibody engineering.

As a Senior Scientist, a typical day could require the following:

  • Apply molecular and structural biology expertise to independently design innovative multi-specific antibodies with desired potency, selectivity and developability.

  • Perform molecular and structural-guided design, high-throughput construct generation, and vector engineering using modern software and tools.

  • Produce and purify novel and logic-gated alternative format antibodies using mammalian expression systems utilizing an assortment of molecular biology & biochemical techniques (i.e. AKTA systems and other chromatographic columns).

  • Characterize binding affinities, binding kinetics & stability.  

  • Design and implement high-throughput and properly controlled biochemical and cell-based assays (ELISA and AlphaLISA, flow cytometry binding, phagocytic assays, cell activation and cytolytic assays).

  • Troubleshoot bioanalytical and cell-based assay data to inform subsequent iterations.

  • Engage program stakeholders to communicate biologic designs with data updates to meet program objectives. 

  • Clearly convey results to management during cross-departmental meetings and maintain timely, accurate entries using Benchling and research ELN.

This role may be a strong fit If You:

  • Have expertise in myeloid, molecular, and protein biology.

  • Learn new skills quickly and troubleshoot antibody production and functional assays effectively.

  • Excel in data analysis and interpretation while supporting multiple projects simultaneously.

  • Competently prioritize efforts to quickly adapt to evolving program directions.

  • Possess exemplary organizational, communication, and presentation skills.

  • Enjoy collaborating across diverse, cross-functional teams.  

To be considered for this role you must have a PhD in molecular biology, cell biology, biochemistry, immunology or a related field with at least one year of relevant experience in academia or industry. Core hands-on experience with cloning, antibody expression in mammalian cell lines, antibody purification (i.e., using AKTA systems), and comprehensive protein characterization is desired; however, we’re excited to train motivated learners. Familiarity with cell-free expression and structural AI/ML-design is preferred but not required.

Salary Range (annually)

$109,900.00 - $179,300.00

About Regeneron Pharmaceuticals, Inc

Regeneron Pharmaceuticals is a biopharmaceutical company that discovers, develops, and commercializes pharmaceutical products for the treatment of serious medical conditions. The Company has therapeutic candidates in clinical trials for the potential treatment of cancer, eye diseases, and inflammatory diseases, and has preclinical programs in other diseases and disorders. The company’s product portfolio includes EYLEA, an aflibercept injection; ARCALYST, a rilonacept Injection for subcutaneous use; ZALTRAP for metastatic colorectal cancer; trap fusion proteins; and fully human monoclonal antibodies. On March 26, 2012, it was announced that Sanofi and Regeneron are in development with a new cholesterol drug which will help reduce cholesterol up to 72%. Regeneron Pharmaceuticals was founded in 1988 and is currently headquartered in New York, USA.

Regeneron Pharmaceuticals, Inc Careers

Join the innovative team at Regeneron Pharmaceuticals, Inc, a leading biotechnology company renowned for its commitment to science-driven solutions. This is an unparalleled opportunity to advance your career with a company at the forefront of medical breakthroughs and clinical research.

Work You’ll Do

At Regeneron Pharmaceuticals, Inc, you will collaborate with some of the brightest minds in the industry, engaging in work that directly contributes to the health and well-being of populations globally. Our diverse team of professionals is dedicated to pioneering developments in biotechnology through continuous innovation and rigorous research.

Explore Job Opportunities and Growth

Regeneron offers a variety of job opportunities that encourage professional growth and personal achievement. Whether you're seeking an entry-level position or a more senior role, you will find a path that aligns with your career ambitions and skills. Our supportive culture emphasizes leadership development and diversity training, ensuring every team member can thrive.

Internship Programs

Kickstart your career with a Regeneron internship. Our programs provide invaluable industry experience, mentoring from seasoned professionals, and opportunities to develop skills that are crucial in the biotech field. Interns at Regeneron gain hands-on experience, contributing to projects that matter.

Benefits and Culture

Choosing to work at Regeneron Pharmaceuticals, Inc means choosing a career that comes with competitive benefits designed to support you both professionally and personally. We offer comprehensive health benefits, retirement plans, and wellness programs. Our inclusive culture fosters an environment where every employee can flourish, driven by collaboration and mutual respect.

Innovation and Leadership

Lead the way in biotechnological innovation with Regeneron. Our leadership is constantly looking towards the future, investing in cutting-edge technology and research that pave the way for medical advancements. At Regeneron, leadership and innovation go hand in hand, creating a dynamic where breakthroughs are common.

Networking and Professional Development

Enhance your professional network and skill set through Regeneron’s extensive networking opportunities and ongoing professional development programs. We believe in nurturing our talent with advanced training sessions and regular workshops that cover the latest trends and technologies in the biotech industry.

Join Our Team

Discover the impact you can make in a career at Regeneron Pharmaceuticals, Inc. Search for open positions that match your skills and interests. We are continuously hiring and looking for passionate, curious, and innovative team players.

Stay Connected

Keep up to date with the latest at Regeneron by following our careers blog. Gain insights from the experts and learn more about the exciting world of biotech at Regeneron Pharmaceuticals, Inc.

Prepare for Your Interview

Ready to join us? Prepare your resume and refine your interview skills to become part of a company that’s dedicated to changing lives. Personalize your job search and get tailored job alerts directly to your inbox, so you never miss an opportunity to be part of our team. At Regeneron Pharmaceuticals, Inc, your career is poised for tremendous growth and innovation. Explore the opportunities today and be part of a team that’s shaping the future of biotechnology.
Learn more about Regeneron Pharmaceuticals, Inc
Size
10,368 employees
Market Cap
$78.1 billion
Industry
Net Income
$3.5 billion
Founded
1988
5 Year Trend
+27%
Revenue
$8.4 billion
NASDAQ

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