Regeneron Pharmaceuticals, Inc

Senior Principal Scientist - Microscopy

Regeneron Pharmaceuticals, Inc • $150K — $245K *
Tarrytown, NY 10591In-Person
Pharmaceuticals & Biotech
5 - 7 years of experience
Today
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Job Overview by Ladders

Qualifications

  • Ph.D. in relevant biological or engineering discipline.
  • 5+ years of postdoctoral or industry experience in microscopy.
  • 5+ years leading a microscopy core facility or similar organization.
  • Expertise in developing advanced microscopy methodologies.
  • Strong publication record with leadership in microscopy research.
  • Deep knowledge of cell biology, optics, and image analysis techniques.
  • Experience selecting and optimizing microscopy platforms.

Responsibilities

  • Advance scientific direction for microscopy aligned with research priorities.
  • Evaluate and adopt emerging technologies for microscopy.
  • Translate complex biological questions into imaging strategies.
  • Lead and develop a high-performing microscopy team.
  • Oversee strategic and operational planning for microscopy function.
  • Establish governance, quality metrics, and training for microscopy services.
  • Guide experimental design, technology troubleshooting, and quantitative analysis.

Benefits

  • On-site work environment in Tarrytown, NY.
  • Opportunity to mentor and lead a scientific team.
  • Engagement in cutting-edge microscopy research and technology integration.
  • Access to advanced imaging technologies and AI applications.
Full Job Description
Senior Principal Scientist of Microscopy

Location: Tarrytown, NY United States - On-site

Discover your role:
  • Advance the scientific direction for microscopy and cellular imaging across Regeneron Research, aligning capabilities with priority biological and therapeutic questions.
  • Identify, evaluate, validate, and adopt emerging technologies based on scientific value, technical performance, scalability, and portfolio need.
  • Provide senior consultation that translates complex biological questions into fit-for-purpose imaging strategies, experimental designs, and quantitative readouts.
  • Lead, develop, and retain a high-performing multidisciplinary microscopy team and foster a culture of scientific rigor, collaboration, innovation, and continuous learning.
  • Oversee annual strategic, operational, workforce, and capital-equipment plans for the microscopy function.
  • Establish governance, metrics, workflows, training, and service models that improve quality, accessibility, reliability, turnaround time, and scientific impact.
  • Provide scientific leadership across advanced optical, super-resolution, spectral, lifetime, label-free, live-cell, 3D, high-content, high-throughput, spatial, and translational microscopy approaches.
  • Guide method selection, assay development, experimental design, technology troubleshooting, and quantitative image analysis, including machine-learning-enabled approaches.
  • Develop scalable imaging infrastructure spanning laboratory automation, robotic image acquisition, image-data management, cloud analytics, AI applications, and digital microscopy.
  • Integrate microscopy with molecular imaging, histology, pathology, spatial biology, and other Imaging Sciences platforms to generate coherent, cross-scale evidence.
  • Partner with discovery, translational, platform, engineering, data science, and technology teams to deliver imaging strategies that inform target validation, mechanism-of-action studies, biomarker development, candidate selection, and translational planning.
  • Mentor microscopy scientists and imaging specialists, build technical depth and scientific leadership, and train researchers in microscopy best practices and experimental design.


This role requires:
  • A Ph.D. in Cell Biology, Cellular Physiology, Developmental Biology, Molecular Biology, Bioengineering, Biophysics, or related discipline.
  • Minimum 5 years of relevant postdoctoral and/or industry experience.
  • Minimum 5 years leading a microscopy core facility or equivalent scientific organization.
  • Demonstrated expertise developing and applying advanced microscopy methodologies to answer complex biological questions.
  • A strong publication record with evidence of leadership as a primary or senior contributor in microscopy-driven research.
  • Deep understanding of cell biology, optical physics, microscopy instrumentation and mechanics, image formation, fluorescent probes and reporters, automation, and quantitative image analysis.
  • Experience selecting, implementing, and optimizing advanced microscopy imaging platforms.
  • Demonstrated success managing scientific staff and multidisciplinary teams.
  • Strong project management and stakeholder engagement experience.
  • Preferred: Recognized external reputation in biological microscopy or imaging sciences.
  • Preferred: Experience building or transforming an imaging core facility.
  • Preferred: Working knowledge of machine learning and AI-driven image analysis.
  • Preferred: Experience with spatial omics and multiplexed imaging platforms is desirable but not required.
  • Preferred: Experience integrating microscopy with in vivo imaging, pathology, and translational biomarker efforts.
  • Preferred: Record of successful strategic technology adoption and innovation.


Success profile:

Within the first several years, this individual will have:
  • Established a clear strategic roadmap for the future of microscopy at Regeneron.
  • Developed and mentored a highly engaged, technically exceptional microscopy team.
  • Expanded the microscopy core from a service-oriented organization into a premier imaging innovation center whilst building strong partnerships across Regeneron research teams.
  • Enabled broad access to advanced microscopy imaging technologies and quantitative analysis workflows.


Salary Range (annually)
$150,500.00 - $245,500.00

About Regeneron Pharmaceuticals, Inc

Regeneron Pharmaceuticals is a biopharmaceutical company that discovers, develops, and commercializes pharmaceutical products for the treatment of serious medical conditions. The Company has therapeutic candidates in clinical trials for the potential treatment of cancer, eye diseases, and inflammatory diseases, and has preclinical programs in other diseases and disorders. The company’s product portfolio includes EYLEA, an aflibercept injection; ARCALYST, a rilonacept Injection for subcutaneous use; ZALTRAP for metastatic colorectal cancer; trap fusion proteins; and fully human monoclonal antibodies. On March 26, 2012, it was announced that Sanofi and Regeneron are in development with a new cholesterol drug which will help reduce cholesterol up to 72%. Regeneron Pharmaceuticals was founded in 1988 and is currently headquartered in New York, USA.

Regeneron Pharmaceuticals, Inc Careers

Join the innovative team at Regeneron Pharmaceuticals, Inc, a leading biotechnology company renowned for its commitment to science-driven solutions. This is an unparalleled opportunity to advance your career with a company at the forefront of medical breakthroughs and clinical research.

Work You’ll Do

At Regeneron Pharmaceuticals, Inc, you will collaborate with some of the brightest minds in the industry, engaging in work that directly contributes to the health and well-being of populations globally. Our diverse team of professionals is dedicated to pioneering developments in biotechnology through continuous innovation and rigorous research.

Explore Job Opportunities and Growth

Regeneron offers a variety of job opportunities that encourage professional growth and personal achievement. Whether you're seeking an entry-level position or a more senior role, you will find a path that aligns with your career ambitions and skills. Our supportive culture emphasizes leadership development and diversity training, ensuring every team member can thrive.

Internship Programs

Kickstart your career with a Regeneron internship. Our programs provide invaluable industry experience, mentoring from seasoned professionals, and opportunities to develop skills that are crucial in the biotech field. Interns at Regeneron gain hands-on experience, contributing to projects that matter.

Benefits and Culture

Choosing to work at Regeneron Pharmaceuticals, Inc means choosing a career that comes with competitive benefits designed to support you both professionally and personally. We offer comprehensive health benefits, retirement plans, and wellness programs. Our inclusive culture fosters an environment where every employee can flourish, driven by collaboration and mutual respect.

Innovation and Leadership

Lead the way in biotechnological innovation with Regeneron. Our leadership is constantly looking towards the future, investing in cutting-edge technology and research that pave the way for medical advancements. At Regeneron, leadership and innovation go hand in hand, creating a dynamic where breakthroughs are common.

Networking and Professional Development

Enhance your professional network and skill set through Regeneron’s extensive networking opportunities and ongoing professional development programs. We believe in nurturing our talent with advanced training sessions and regular workshops that cover the latest trends and technologies in the biotech industry.

Join Our Team

Discover the impact you can make in a career at Regeneron Pharmaceuticals, Inc. Search for open positions that match your skills and interests. We are continuously hiring and looking for passionate, curious, and innovative team players.

Stay Connected

Keep up to date with the latest at Regeneron by following our careers blog. Gain insights from the experts and learn more about the exciting world of biotech at Regeneron Pharmaceuticals, Inc.

Prepare for Your Interview

Ready to join us? Prepare your resume and refine your interview skills to become part of a company that’s dedicated to changing lives. Personalize your job search and get tailored job alerts directly to your inbox, so you never miss an opportunity to be part of our team. At Regeneron Pharmaceuticals, Inc, your career is poised for tremendous growth and innovation. Explore the opportunities today and be part of a team that’s shaping the future of biotechnology.
Learn more about Regeneron Pharmaceuticals, Inc
Size
10,368 employees
Market Cap
$78.1 billion
Industry
Pharmaceuticals & Biotech
Net Income
$3.5 billion
Founded
1988
5 Year Trend
+27%
Revenue
$8.4 billion
NASDAQ
REGN
* Ladders Estimates

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