Roche

Senior Principal Scientist: Metabolomics/Cell Therapy Media Development

Roche$143K — $266K *
Pharmaceuticals & Biotech
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • PhD in biological sciences, chemical engineering, or related discipline
  • 5+ years of relevant R&D experience in metabolomics and/or cell culture media development
  • Proven leadership in managing complex technical projects
  • Experience in team development and fostering an inclusive environment
  • Strong communication skills with experience in peer-reviewed publications and presentations

Responsibilities

  • Lead metabolomics research initiatives for cell therapy media optimization
  • Design and develop chemically-defined media platforms for various cell therapies
  • Apply advanced metabolomics tools to enhance cell culture performance
  • Collaborate on technology transfer to implement scalable processes
  • Provide strategic guidance to optimize raw materials and process development
  • Mentor scientific staff to promote lean thinking and technical excellence
  • Engage with internal and external stakeholders to ensure alignment on priorities

Benefits

  • Relocation benefits available
  • Participation in a collaborative and inclusive team culture
  • Opportunities for professional growth and mentoring
  • Engagement in thought leadership through publications and presentations
Full Job Description

This role is a vital part of our Cell Therapy Process Development team within Pharma Technical Cell and Gene Therapy Development (PTCC), which is committed to advancing next-generation cell therapies through innovative metabolomics research and media optimization. 

As a member of this team, you will lead cutting-edge efforts to develop and optimize cell culture media platforms while collaborating closely with key stakeholders across Analytical Development, Research, Manufacturing Operations, and cross-functional teams within Genentech and Roche. You will serve as the primary in-house expert on state-of-the-art cell therapy media development practices, translating deep scientific expertise into strategic innovations that enable breakthrough therapies to reach patients. This position offers the opportunity to shape the future of cell therapy manufacturing while fostering a collaborative, inclusive team culture focused on continuous improvement.

The Opportunity

In this role, you will lead metabolomics research initiatives focused on developing and optimizing cell culture media for a diverse portfolio of cell therapy products. You will provide scientific and strategic guidance to establish highly-productive platform processes while serving as the primary technical expert and thought leader in cell therapy media development. Additional responsibilities include:

  • Designing and developing chemically-defined cell culture media platforms tailored to meet the unique needs of T cell therapies, stem cell therapies, and other cell-based products

  • Applying advanced metabolomics tools, computational methods, and -omics technologies to deeply understand cell metabolism and drive continuous improvement in cell culture performance

  • Leading technology transfer initiatives and collaborate with manufacturing operations to translate laboratory innovations into scalable, robust processes

  • Providing technical leadership and strategic guidance to process development teams, media preparation operations, and supply chain partners to resolve complex challenges and optimize raw material selection

  • Mentoring and developing scientific staff within the Cell Therapy Process Development group, fostering a culture of technical excellence, lean thinking, and continuous improvement

  • Interfacing effectively across multiple internal stakeholder groups (Analytical Development, Research, Manufacturing, Quality) and external collaborators to align priorities and drive impactful outcomes

  • Establishing thought leadership through peer-reviewed publications, conference presentations, and participation in industry discussions on metabolomics and cell therapy manufacturing

This position may be based out of South San Francisco or San Diego, CA.

Who You Are
The successful candidate will have an established track record for strong technical leadership in metabolomics research and/or cell culture media development.

  • Advanced degree and extensive experience: PhD in biological sciences, chemical engineering, or related discipline with 5+ years of relevant research and development experience in metabolomics and/or cell culture media development

  • Strategic technical leadership: Proven track record of leading complex technical projects from conception to completion with strong organizational skills and scientific rigor; demonstrated ability to translate research insights into practical manufacturing solutions

  • Team development and inclusive leadership: Demonstrated success building, managing, and developing highly productive technical teams with an emphasis on creating an inclusive environment that values diverse perspectives and fosters collaboration

  • Matrixed stakeholder management: Proven ability to build and maintain strong relationships with cross-functional partners, customers, and collaborators; excellent skills in influencing, communication, and working effectively across organizational boundaries in complex matrixed environments

  • Thought leadership and communication: Established track record of excellent verbal and written communication demonstrated through peer-reviewed publications, conference presentations, and ability to articulate complex scientific concepts to audiences at all levels

The expected salary range for this position based on the primary location of California is $143,290 - $266,110. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  A discretionary annual bonus may be available based on individual and Company performance.  This position also qualifies for the benefits detailed at this

Relocation benefits are available for this position.

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About Roche

Roche Holding AG is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has bearer shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel. Roche is the largest pharmaceutical company in the world, and the leading provider of cancer treatments globally. The company also produces a range of diagnostic tests for medical professionals and patients. Roche was one of the first companies to bring targeted treatments to patients. In 2019, Roche had over 100,000 employees worldwide, and generated revenue of CHF 61.5 billion.
Learn more about Roche
Size
100,920 employees
Industry
NASDAQ

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